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Meanwhile, our improved understanding of the molecular mechanisms involved in solute and water transport across the peritoneum and of the pathobiology of structural and functional changes in the peritoneum with long-term PD has provided new targets for improving efficiency and for intervention. As with hemodialysis, almost half of all deaths on PD occur because of cardiovascular events, and there is great interest in identifying modality-specific factors contributing to these events. Notably, tremendous progress has been made in developing interventions that substantially reduce the risk of PD-related peritonitis. Yet the gains have been unequal among individual centers, primarily because of unequal clinical application of knowledge gained from research. The work to date has further highlighted the areas in need of innovation as we continue to strive to improve the health and outcomes of patients treated with PD.<\/jats:p>","DOI":"10.1681\/asn.2016010112","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T10:52:22Z","timestamp":1466851942000},"page":"3238-3252","source":"Crossref","is-referenced-by-count":483,"title":["The Current State of Peritoneal Dialysis"],"prefix":"10.1681","volume":"27","author":[{"given":"Rajnish","family":"Mehrotra","sequence":"first","affiliation":[{"name":"Kidney Research Institute and"},{"name":"Harborview Medical Center, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Devuyst","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, Zurich, Switzerland;"},{"name":"Division of Nephrology, Universit\u00e9 Catholique de Louvain Medical School, Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Keele University, Staffordshire, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Division of Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"key":"B1-20231016","first-page":"1478","article-title":"Uber die Beseitigung giftiger Stoffe aus dem Blute durch Dialyse.","volume":"70","author":"Ganter","year":"1923","journal-title":"Munch Med Wochenschr"},{"key":"B2-20231016","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-5347(17)71834-4","article-title":"Peritoneal lavage in the treatment of uremia: an experimental and clinical study.","volume":"39","author":"Wear","year":"1938","journal-title":"J Urol"},{"key":"B3-20231016","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1001\/jama.1946.02870110027008a","article-title":"Treatment of uremia after acute renal failure by peritoneal irrigation.","volume":"130","author":"Frank","year":"1946","journal-title":"J Am Med Assoc"},{"key":"B4-20231016","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1172\/JCI101699","article-title":"Treatment of Experimental Uremia by Means of Peritoneal Irrigation.","volume":"25","author":"Seligman","year":"1946","journal-title":"J Clin Invest"},{"key":"B5-20231016","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00000658-194809000-00018","article-title":"Further experiences with peritoneal irrigation for acuter renal failure including a description of modifications in method.","volume":"128","author":"Frank","year":"1948","journal-title":"Ann Surg"},{"key":"B6-20231016","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0002-9343(50)90009-X","article-title":"Peritoneal lavage as an effective means of extrarenal excretion; a clinical appraisal.","volume":"9","author":"Odel","year":"1950","journal-title":"Am J Med"},{"key":"B7-20231016","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archinte.1951.03810030052005","article-title":"Intermittent peritoneal lavage in nephrectomized dogs and its application to the human being.","volume":"87","author":"Grollman","year":"1951","journal-title":"AMA Arch Intern Med"},{"key":"B8-20231016","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0002-9343(59)90205-0","article-title":"An evaluation of intermittent peritoneal lavage.","volume":"26","author":"Doolan","year":"1959","journal-title":"Am J Med"},{"key":"B9-20231016","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1001\/jama.1959.03010080025004","article-title":"Peritoneal dialysis. 1. 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