{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:08:59Z","timestamp":1790284139801,"version":"4.1.0"},"reference-count":88,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    Highly aerobic organs like the kidney are innately susceptible to ischemia-reperfusion (I\/R) injury, which can originate from sources including myocardial infarction, renal trauma, and transplant. Therapy is mainly supportive and depends on the cause(s) of damage. In the absence of hypervolemia, intravenous fluid delivery is frequently the first course of treatment but does not reverse established AKI. Evidence suggests that disrupting leukocyte adhesion may prevent the impairment of renal microvascular perfusion and the heightened inflammatory response that exacerbate ischemic renal injury. We investigated the therapeutic potential of hydrodynamic isotonic fluid delivery (HIFD) to the left renal vein 24 hours after inducing moderate-to-severe unilateral IRI in rats. HIFD significantly increased hydrostatic pressure within the renal vein. When conducted after established AKI, 24 hours after I\/R injury, HIFD produced substantial and statistically significant decreases in serum creatinine levels compared with levels in animals given an equivalent volume of saline\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    peripheral infusion (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.05). Intravital confocal microscopy performed immediately after HIFD showed improved microvascular perfusion. Notably, HIFD also resulted in immediate enhancement of parenchymal labeling with the fluorescent dye Hoechst 33342. HIFD also associated with a significant reduction in the accumulation of renal leukocytes, including proinflammatory T cells. Additionally, HIFD significantly reduced peritubular capillary erythrocyte congestion and improved histologic scores of tubular injury 4 days after IRI. Taken together, these results indicate that HIFD performed after establishment of AKI rapidly restores microvascular perfusion and small molecule accessibility, with improvement in overall renal function.\n                  <\/jats:p>","DOI":"10.1681\/asn.2016040404","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T21:00:25Z","timestamp":1485378025000},"page":"2081-2092","source":"Crossref","is-referenced-by-count":39,"title":["Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys"],"prefix":"10.1681","volume":"28","author":[{"given":"Jason A.","family":"Collett","sequence":"first","affiliation":[{"name":"Department of Cellular and Integrative Physiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Corridon","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Biology, University of Colorado Denver, Anschutz Campus, Aurora, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purvi","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Kolb","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University\u2013Purdue University, Indianapolis, Indiana; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Molitoris","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,"},{"name":"Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice G.","family":"Pennington","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben M.","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University\u2013Purdue University, Indianapolis, Indiana; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia B.","family":"Campos-Bilderback","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology,"},{"name":"Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Bacallao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,"},{"name":"Department of Medicine, Division of Nephrology, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"B1-20230829","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/cphy.c110041","article-title":"Pathophysiology of acute kidney injury.","volume":"2","author":"Basile","year":"2012","journal-title":"Compr Physiol"},{"key":"B2-20230829","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1046\/j.1523-1755.2002.00631.x","article-title":"Microvascular endothelial injury and dysfunction during ischemic acute renal failure.","volume":"62","author":"Sutton","year":"2002","journal-title":"Kidney Int"},{"key":"B3-20230829","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1523-1755.2004.761_5.x","article-title":"Endothelial injury and dysfunction: Role in the extension phase of acute renal failure.","volume":"66","author":"Molitoris","year":"2004","journal-title":"Kidney Int"},{"key":"B4-20230829","doi-asserted-by":"crossref","first-page":"F1140","DOI":"10.1152\/ajprenal.00329.2001","article-title":"Endothelial dysfunction in ischemic acute renal failure: Rescue by transplanted endothelial cells.","volume":"282","author":"Brodsky","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"B5-20230829","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/pgmj.2005.038588","article-title":"Management of acute renal failure.","volume":"82","author":"Fry","year":"2006","journal-title":"Postgrad Med J"},{"key":"B6-20230829","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/ki.1996.280","article-title":"\u201cRenal-dose\u201d dopamine for the treatment of acute renal failure: Scientific rationale, experimental studies and clinical trials.","volume":"50","author":"Denton","year":"1996","journal-title":"Kidney Int"},{"key":"B7-20230829","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000443152","article-title":"Acute kidney injury prevention.","volume":"187","author":"Chopra","year":"2016","journal-title":"Contrib Nephrol"},{"key":"B8-20230829","doi-asserted-by":"crossref","first-page":"F1150","DOI":"10.1152\/ajprenal.00310.2001","article-title":"Intravital videomicroscopy of peritubular capillaries in renal ischemia.","volume":"282","author":"Yamamoto","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"B9-20230829","first-page":"635","article-title":"The no reflow phenomenon in renal ischemia.","volume":"25","author":"Summers","year":"1971","journal-title":"Lab Invest"},{"key":"B10-20230829","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1681\/ASN.2014060577","article-title":"Reduction of tubular flow rate as a mechanism of oliguria in the early phase of endotoxemia revealed by intravital imaging.","volume":"26","author":"Nakano","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B11-20230829","doi-asserted-by":"crossref","first-page":"F261","DOI":"10.1152\/ajprenal.00263.2006","article-title":"Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice.","volume":"292","author":"Wu","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"B12-20230829","doi-asserted-by":"crossref","first-page":"F1217","DOI":"10.1152\/ajprenal.00070.2013","article-title":"A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors.","volume":"304","author":"Corridon","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"B13-20230829","doi-asserted-by":"crossref","first-page":"F191","DOI":"10.1152\/ajprenal.00042.2003","article-title":"Injury of the renal microvascular endothelium alters barrier function after ischemia.","volume":"285","author":"Sutton","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"B14-20230829","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1172\/JCI113628","article-title":"Smooth muscle calcium and endothelium-derived relaxing factor in the abnormal vascular responses of acute renal failure.","volume":"82","author":"Conger","year":"1988","journal-title":"J Clin Invest"},{"key":"B15-20230829","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ki.1984.171","article-title":"Role of the medullary perfusion defect in the pathogenesis of ischemic renal failure.","volume":"26","author":"Mason","year":"1984","journal-title":"Kidney Int"},{"key":"B16-20230829","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/08860228909054930","article-title":"Role of vascular decongestion in ischemic acute renal failure defined by postinsult administration of pentoxifylline.","volume":"11","author":"Luke","journal-title":"Ren Fail"},{"key":"B17-20230829","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-4827(85)80052-5","article-title":"Measurement of cell proliferation in microculture using Hoechst 33342 for the rapid semiautomated microfluorimetric determination of chromatin DNA.","volume":"159","author":"Richards","year":"1985","journal-title":"Exp Cell Res"},{"key":"B18-20230829","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01.mnh.0000436695.29173.de","article-title":"Expanding role of T cells in acute kidney injury.","volume":"23","author":"Kinsey","year":"2014","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B19-20230829","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrneph.2011.16","article-title":"Pathophysiology of ischemic acute kidney injury.","volume":"7","author":"Sharfuddin","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"B20-20230829","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/ki.1997.200","article-title":"Leukocytes, cell adhesion molecules and ischemic acute renal failure.","volume":"51","author":"Rabb","year":"1997","journal-title":"Kidney Int"},{"key":"B21-20230829","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1681\/ASN.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair.","volume":"22","author":"Lee","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B22-20230829","doi-asserted-by":"crossref","first-page":"137072","DOI":"10.1155\/2009\/137072","article-title":"Mediators of inflammation in acute kidney injury.","volume":"2009","author":"Akcay","year":"2009","journal-title":"Mediators Inflamm"},{"key":"B23-20230829","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1523-1755.2004.761_4.x","article-title":"T cells as mediators in renal ischemia\/reperfusion injury.","volume":"66","author":"Ysebaert","year":"2004","journal-title":"Kidney Int"},{"key":"B24-20230829","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/00007890-200209270-00005","article-title":"Protective effect of T cell depletion in murine renal ischemia-reperfusion injury.","volume":"74","author":"Yokota","year":"2002","journal-title":"Transplantation"},{"key":"B25-20230829","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.4049\/jimmunol.176.5.3108","article-title":"Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: The role of CD4+ T cells and IFN-gamma.","volume":"176","author":"Day","year":"2006","journal-title":"J Immunol"},{"key":"B26-20230829","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1523-1755.2004.761_3.x","article-title":"Inflammatory cells in ischemic acute renal failure.","volume":"66","author":"Friedewald","year":"2004","journal-title":"Kidney Int"},{"key":"B27-20230829","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/ndt\/15.10.1562","article-title":"Identification and kinetics of leukocytes after severe ischaemia\/reperfusion renal injury.","volume":"15","author":"Ysebaert","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"B28-20230829","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ki.2015.200","article-title":"Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism.","volume":"88","author":"Mehrotra","year":"2015","journal-title":"Kidney Int"},{"issue":"Suppl","key":"B29-20230829","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1097\/00003246-200205001-00011","article-title":"Endothelial injury and dysfunction in ischemic acute renal failure.","volume":"30","author":"Molitoris","year":"2002","journal-title":"Crit Care Med"},{"key":"B30-20230829","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00007890-200107270-00008","article-title":"Reduction of severe ischemia\/reperfusion injury in rat kidney grafts by a soluble P-selectin glycoprotein ligand.","volume":"72","author":"Fuller","year":"2001","journal-title":"Transplantation"},{"key":"B31-20230829","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1073\/pnas.91.2.812","article-title":"Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury.","volume":"91","author":"Kelly","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"B33-20230829","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1046\/j.1523-1755.2000.00269.x","article-title":"Antibodies to both ICAM-1 and LFA-1 do not protect the kidney against toxic (HgCl2) injury.","volume":"58","author":"Ghielli","year":"2000","journal-title":"Kidney Int"},{"key":"B34-20230829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00041552-200401000-00001","article-title":"Rarefaction of peritubular capillaries following ischemic acute renal failure: A potential factor predisposing to progressive nephropathy.","volume":"13","author":"Basile","year":"2004","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B35-20230829","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ki.1991.254","article-title":"Red cell trapping and postischemic renal blood flow. Differences between the cortex, outer and inner medulla.","volume":"40","author":"Olof","year":"1991","journal-title":"Kidney Int"},{"key":"B36-20230829","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1681\/ASN.2008060593","article-title":"Soluble thrombomodulin protects ischemic kidneys.","volume":"20","author":"Sharfuddin","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B37-20230829","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ki.1974.74","article-title":"Medullary plasma flow and intravascular leukocyte accumulation in acute renal failure.","volume":"6","author":"Solez","year":"1974","journal-title":"Kidney Int"},{"key":"B38-20230829","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/ki.1990.223","article-title":"Nephron function in the early phase of ischemic renal failure. Significance of erythrocyte trapping.","volume":"38","author":"Hellberg","year":"1990","journal-title":"Kidney Int"},{"key":"B39-20230829","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1871529X1401140724093505","article-title":"Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.","volume":"14","author":"Basile","year":"2014","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"B40-20230829","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mvr.2015.06.005","article-title":"Combined peri-ischemic administration of B\u03b215-42 in treating ischemia reperfusion injury of the mouse kidney.","volume":"101","author":"Urbschat","year":"2015","journal-title":"Microvasc Res"},{"key":"B41-20230829","first-page":"S23","article-title":"Renal-dose (low-dose) dopamine for the treatment of sepsis-related and other forms of acute renal failure: Ineffective and probably dangerous.","volume":"26","author":"Power","year":"1999","journal-title":"Clin Exp Pharmacol Physiol Suppl"},{"key":"B42-20230829","first-page":"1","article-title":"The prevention of acute kidney injury an in-depth narrative review: Part 2: Drugs in the prevention of acute kidney injury.","volume":"2","author":"Lameire","year":"2009","journal-title":"NDT Plus"},{"key":"B43-20230829","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/S0140-6736(00)03495-4","article-title":"Low-dose dopamine in patients with early renal dysfunction: A placebo-controlled randomised trial.","volume":"356","author":"Bellomo","year":"2000","journal-title":"Lancet"},{"key":"B44-20230829","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/pgmj.75.883.269","article-title":"Can the use of low-dose dopamine for treatment of acute renal failure be justified?","volume":"75","author":"Burton","year":"1999","journal-title":"Postgrad Med J"},{"key":"B45-20230829","doi-asserted-by":"crossref","first-page":"510","DOI":"10.7326\/0003-4819-142-7-200504050-00010","article-title":"Meta-analysis: Low-dose dopamine increases urine output but does not prevent renal dysfunction or death.","volume":"142","author":"Friedrich","year":"2005","journal-title":"Ann Intern Med"},{"key":"B46-20230829","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1097\/00003246-200108000-00005","article-title":"Use of dopamine in acute renal failure: A meta-analysis.","volume":"29","author":"Kellum","year":"2001","journal-title":"Crit Care Med"},{"key":"B48-20230829","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0735-1097(03)00903-3","article-title":"Retrograde coronary perfusion: A superior route to deliver therapeutics to the heart?*.","volume":"42","author":"Giordano","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"B49-20230829","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1002\/ccd.24659","article-title":"Intracoronary and retrograde coronary venous myocardial delivery of adipose-derived stem cells in swine infarction lead to transient myocardial trapping with predominant pulmonary redistribution.","volume":"83","author":"Hong","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"key":"B50-20230829","doi-asserted-by":"crossref","first-page":"S357","DOI":"10.1016\/j.ymthe.2004.06.860","article-title":"934. Comparing two modalities of myocardial gene delivery: Percutaneous retrograde coronary venous delivery and intramyocardial injection.","volume":"9","author":"Youssef","year":"2004","journal-title":"Mol Ther"},{"key":"B51-20230829","first-page":"393","article-title":"First human case of retrograde transcatheter implantation of an aortic valve prosthesis.","volume":"32","author":"Paniagua","year":"2005","journal-title":"Tex Heart Inst J"},{"key":"B52-20230829","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1186\/cc11480","article-title":"Mannitol increases renal blood flow and maintains filtration fraction and oxygenation in postoperative acute kidney injury: A prospective interventional study.","volume":"16","author":"Bragadottir","year":"2012","journal-title":"Crit Care"},{"key":"B53-20230829","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1681\/ASN.2015030233","article-title":"Therapeutic targets of human AKI: Harmonizing human and animal AKI.","volume":"27","author":"Okusa","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B54-20230829","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.2000.278.1.F1","article-title":"Acute renal failure. II. Experimental models of acute renal failure: Imperfect but indispensable.","volume":"278","author":"Lieberthal","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"B55-20230829","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ki.1975.4","article-title":"The effect of ischemia on renal blood flow in the dog.","volume":"7","author":"Riley","year":"1975","journal-title":"Kidney Int"},{"key":"B56-20230829","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1681\/ASN.2012080786","article-title":"Tolerance of the human kidney to isolated controlled ischemia.","volume":"24","author":"Parekh","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B57-20230829","first-page":"S128","article-title":"Intrarenal hemodynamics following temporary occlusion of the renal artery in the dog.","volume":"6","author":"B\u00e1lint","year":"1976","journal-title":"Kidney Int Suppl"},{"key":"B58-20230829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.1982.tb07039.x","article-title":"Postischemic renal failure. Intrarenal blood flow and functional characteristics in the recovery phase.","volume":"115","author":"Karlberg","year":"1982","journal-title":"Acta Physiol Scand"},{"key":"B59-20230829","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s004670050332","article-title":"Delayed acute renal failure in post-transplant period in young children from unexplained etiology.","volume":"11","author":"Vats","year":"1997","journal-title":"Pediatr Nephrol"},{"key":"B60-20230829","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00134-009-1723-x","article-title":"Histopathology of septic shock induced acute kidney injury: Apoptosis and leukocytic infiltration.","volume":"36","author":"Lerolle","year":"2010","journal-title":"Intensive Care Med"},{"key":"B61-20230829","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ki.2009.347","article-title":"Experimental ischemia-reperfusion: Biases and myths-the proximal vs. distal hypoxic tubular injury debate revisited.","volume":"77","author":"Heyman","year":"2010","journal-title":"Kidney Int"},{"key":"B62-20230829","first-page":"566","article-title":"Erythrocyte deformation in ischemic acute tubular necrosis and amelioration by splenectomy in the dog.","volume":"65","author":"Mandal","year":"1991","journal-title":"Lab Invest"},{"key":"B64-20230829","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1681\/ASN.2015030261","article-title":"Inflammation in AKI: Current understanding, key questions, and knowledge gaps.","volume":"27","author":"Rabb","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B65-20230829","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semnephrol.2006.09.008","article-title":"Leukocyte-renal epithelial cell interactions regulate lupus nephritis.","volume":"27","author":"Kelley","year":"2007","journal-title":"Semin Nephrol"},{"key":"B66-20230829","doi-asserted-by":"crossref","first-page":"F525","DOI":"10.1152\/ajprenal.2000.279.3.F525","article-title":"Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice.","volume":"279","author":"Rabb","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"B67-20230829","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrneph.2014.180","article-title":"Immune cells in experimental acute kidney injury.","volume":"11","author":"Jang","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"B68-20230829","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/01.sla.0000256862.79374.31","article-title":"Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein C pathway?","volume":"245","author":"Brohi","year":"2007","journal-title":"Ann Surg"},{"key":"B69-20230829","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1046\/j.1523-1755.2001.00944.x","article-title":"Anti-B7-1 blocks mononuclear cell adherence in vasa recta after ischemia.","volume":"60","author":"De Greef","year":"2001","journal-title":"Kidney Int"},{"key":"B70-20230829","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1172\/JCI200112080","article-title":"Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure.","volume":"108","author":"Burne","year":"2001","journal-title":"J Clin Invest"},{"key":"B71-20230829","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.ajpath.2014.01.023","article-title":"Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation.","volume":"184","author":"Chan","year":"2014","journal-title":"Am J Pathol"},{"key":"B72-20230829","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1172\/JCI6974","article-title":"Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation.","volume":"104","author":"Daemen","year":"1999","journal-title":"J Clin Invest"},{"key":"B73-20230829","doi-asserted-by":"crossref","first-page":"F760","DOI":"10.1152\/ajprenal.00050.2004","article-title":"Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury.","volume":"287","author":"Kelly","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"B74-20230829","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/01.ASN.0000040596.23073.01","article-title":"P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: Protective role of a p53 inhibitor.","volume":"14","author":"Kelly","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"B75-20230829","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1523-1755.2004.00415.x","article-title":"5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia\/reperfusion.","volume":"65","author":"Chatterjee","year":"2004","journal-title":"Kidney Int"},{"key":"B76-20230829","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1172\/JCI113325","article-title":"Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats.","volume":"81","author":"Walker","year":"1988","journal-title":"J Clin Invest"},{"key":"B77-20230829","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1081\/DMR-100101947","article-title":"Oxidant mechanisms in toxic acute renal failure.","volume":"31","author":"Baliga","year":"1999","journal-title":"Drug Metab Rev"},{"key":"B78-20230829","doi-asserted-by":"crossref","first-page":"12351","DOI":"10.1073\/pnas.192222999","article-title":"Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.","volume":"99","author":"Ulloa","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"B79-20230829","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1046\/j.1523-1755.2003.00268.x","article-title":"Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice.","volume":"64","author":"Miyaji","year":"2003","journal-title":"Kidney Int"},{"key":"B80-20230829","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.4049\/jimmunol.153.8.3664","article-title":"Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.","volume":"153","author":"Grey","year":"1994","journal-title":"J Immunol"},{"key":"B81-20230829","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1056\/NEJMoa011300","article-title":"Intensive insulin therapy in critically ill patients.","volume":"345","author":"van den Berghe","year":"2001","journal-title":"N Engl J Med"},{"key":"B82-20230829","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1146\/annurev.pharmtox.41.1.775","article-title":"Molecular approach to adenosine receptors: Receptor-mediated mechanisms of tissue protection.","volume":"41","author":"Linden","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B83-20230829","first-page":"F404","article-title":"Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney.","volume":"277","author":"Okusa","year":"1999","journal-title":"Am J Physiol"},{"key":"B84-20230829","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2044.2009.06228.x","article-title":"Benefits and risks of furosemide in acute kidney injury.","volume":"65","author":"Ho","year":"2010","journal-title":"Anaesthesia"},{"key":"B85-20230829","first-page":"251","article-title":"Diuretics in acute kidney injury.","volume":"75","author":"Karajala","year":"2009","journal-title":"Minerva Anestesiol"},{"key":"B86-20230829","doi-asserted-by":"crossref","first-page":"F721","DOI":"10.1152\/ajprenal.00546.2010","article-title":"Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury.","volume":"300","author":"Basile","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"B88-20230829","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00004647-200103000-00002","article-title":"Dynamic imaging of cerebral blood flow using laser speckle.","volume":"21","author":"Dunn","year":"2001","journal-title":"J Cereb Blood Flow Metab"},{"key":"B89-20230829","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5405\/jmbe.875","article-title":"Red blood cell velocity measurement in rodent tumor model: An in vivo microscopic study.","volume":"32","author":"Lin","year":"2011","journal-title":"J Med Biol Eng"},{"key":"B90-20230829","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis.","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"B91-20230829","first-page":"36","article-title":"Image processing with ImageJ.","volume":"11","author":"Abr\u00e0moff","year":"2004","journal-title":"Biophoton Int"},{"key":"B92-20230829","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/ki.2012.391","article-title":"Chromosome substitution modulates resistance to ischemia reperfusion injury in Brown Norway rats.","volume":"83","author":"Basile","year":"2013","journal-title":"Kidney Int"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201707000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:28:39Z","timestamp":1786130919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201707000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,25]]},"references-count":88,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2016040404","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,25]]}}}