{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:36:02Z","timestamp":1792704962696,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,5]]},"abstract":"\n De novo<\/jats:italic>\n expression in the kidney of periostin, a protein involved in odontogenesis and osteogenesis, has been suggested as a biomarker of renal disease. In this study, we investigated the mechanism(s) of induction and the role of periostin in renal disease. Using a combination of bioinformatics, reporter assay, and chromatin immunoprecipitation analyses, we found that NF\n \u03ba<\/jats:italic>\n B and other proinflammatory transcription factors induce periostin expression\n in vitro<\/jats:italic>\n and that binding of these factors on the periostin promoter is enriched in glomeruli during experimental GN. Mice lacking expression of periostin displayed preserved renal function and structure during GN. Furthermore, delayed administration of periostin antisense oligonucleotides in wild-type animals with GN reversed already established proteinuria, diminished tissue inflammation, and improved renal structure. Lack of periostin expression also blunted the\n de novo<\/jats:italic>\n renal expression of integrin-\n \u03b2<\/jats:italic>\n 3 and phosphorylation of focal adhesion kinase and AKT, known mediators of integrin-\n \u03b2<\/jats:italic>\n 3 signaling that affect cell motility and survival, observed during GN in wild-type animals.\n In vitro<\/jats:italic>\n , recombinant periostin increased the expression of integrin-\n \u03b2<\/jats:italic>\n 3 and the concomitant phosphorylation of focal adhesion kinase and AKT in podocytes. Notably, periostin and integrin-\n \u03b2<\/jats:italic>\n 3 were highly colocalized in biopsy specimens from patients with inflammatory GN. These results demonstrate that interplay between periostin and renal inflammation orchestrates inflammatory and fibrotic responses, driving podocyte damage through downstream activation of integrin-\n \u03b2<\/jats:italic>\n 3 signaling. Targeting periostin may be a novel therapeutic strategy for treating CKD.\n <\/jats:p>","DOI":"10.1681\/asn.2016070709","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T22:00:30Z","timestamp":1480975230000},"page":"1475-1490","source":"Crossref","is-referenced-by-count":64,"title":["NF\u03baB-Induced Periostin Activates Integrin-\u03b23 Signaling to Promote Renal Injury in GN"],"prefix":"10.1681","volume":"28","author":[{"given":"Niki","family":"Prakoura","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche Scientifique 1155, Tenon Hospital, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Kavvadas","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche Scientifique 1155, Tenon Hospital, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u0451l","family":"Kormann","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche Scientifique 1155, Tenon Hospital, Paris, France;"},{"name":"Sorbonne Universit\u00e9, Universit\u00e9 Pierre-et-Marie-Curie Paris 6, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Dussaule","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche Scientifique 1155, Tenon Hospital, Paris, France;"},{"name":"Sorbonne Universit\u00e9, Universit\u00e9 Pierre-et-Marie-Curie Paris 6, Paris, France; and"},{"name":"Department of Physiology, Saint-Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos E.","family":"Chadjichristos","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche Scientifique 1155, Tenon Hospital, Paris, France;"},{"name":"Sorbonne Universit\u00e9, Universit\u00e9 Pierre-et-Marie-Curie Paris 6, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Chatziantoniou","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 Et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche Scientifique 1155, Tenon Hospital, Paris, France;"},{"name":"Sorbonne Universit\u00e9, Universit\u00e9 Pierre-et-Marie-Curie Paris 6, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"B1-20230829","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1359\/jbmr.1999.14.7.1239","article-title":"Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta.","volume":"14","author":"Horiuchi","year":"1999","journal-title":"J Bone Miner Res"},{"key":"B2-20230829","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0925-4773(01)00356-2","article-title":"Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation.","volume":"103","author":"Kruzynska-Frejtag","year":"2001","journal-title":"Mech Dev"},{"key":"B3-20230829","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.21224","article-title":"Periostin regulates 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