{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:40:31Z","timestamp":1791268831292,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n                    Vancomycin is a widely prescribed antibiotic, but the exact nature of vancomycin-associated nephrotoxicity is unclear, in particular when considering the frequent coadministration of aminoglycosides. We describe here the initial case of a 56-year-old woman with normal renal function developing unexplained ARF without hypovolemia after administration of vancomycin without coadministration of aminoglycosides. Studying the patient\u2019s renal biopsy specimen, we ascertained that obstructive tubular casts composed of noncrystal nanospheric vancomycin aggregates entangled with uromodulin explained the vancomycin-associated ARF. We developed in parallel a new immunohistologic staining technique to detect vancomycin in renal tissue and confirmed retrospectively that deleterious vancomycin-associated casts existed in eight additional patients with acute tubular necrosis in the absence of hypovolemia. Concomitant high vancomycin trough plasma levels had been observed in each patient. We also reproduced experimentally the toxic and obstructive nature of vancomycin-associated cast nephropathy in mice, which we detected using different\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    imaging techniques. In conclusion, the interaction of uromodulin with nanospheric vancomycin aggregates represents a new mode of tubular cast formation, revealing the hitherto unsuspected mechanism of vancomycin-associated renal injury.\n                  <\/jats:p>","DOI":"10.1681\/asn.2016080867","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T21:00:33Z","timestamp":1484254833000},"page":"1723-1728","source":"Crossref","is-referenced-by-count":133,"title":["Vancomycin-Associated Cast Nephropathy"],"prefix":"10.1681","volume":"28","author":[{"given":"Yosu","family":"Luque","sequence":"first","affiliation":[{"name":"Urgences N\u00e9phrologiques et Transplantation r\u00e9nale, H\u00f4pital Tenon, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"},{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Univ Paris 6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Louis","sequence":"additional","affiliation":[{"name":"Urgences N\u00e9phrologiques et Transplantation r\u00e9nale, H\u00f4pital Tenon, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Jouanneau","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Placier","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Esteve","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bazin","sequence":"additional","affiliation":[{"name":"Laboratoire de chimie de la mati\u00e8re condens\u00e9e de Paris, Coll\u00e8ge de France, Centre r\u00e9gional de la Recherche Scientifique Unit\u00e9 Mixte de Recherche_7574, Laboratoire de physique des solides, universit\u00e9 Paris XI, Paris, France;"},{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Univ Paris 6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rondeau","sequence":"additional","affiliation":[{"name":"Urgences N\u00e9phrologiques et Transplantation r\u00e9nale, H\u00f4pital Tenon, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"},{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Univ Paris 6, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Letavernier","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"},{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Univ Paris 6, Paris, France;"},{"name":"Explorations fonctionnelles multidisciplinaires, H\u00f4pital Tenon, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Wolfromm","sequence":"additional","affiliation":[{"name":"H\u00e9matologie Clinique Adulte, H\u00f4pital Necker- Enfants malades, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Gosset","sequence":"additional","affiliation":[{"name":"Anatomie pathologique, H\u00f4pital Saint-Louis, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Boueilh","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie-Transplantation, H\u00f4pital Saint-Louis, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Burbach","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie-Transplantation, H\u00f4pital Saint-Louis, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Fr\u00e8re","sequence":"additional","affiliation":[{"name":"Imaging and Cytometry Facility of Tenon, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodelling and Tissue Repair, Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Univ Paris 6, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Verpont","sequence":"additional","affiliation":[{"name":"Imaging and Cytometry Facility of Tenon, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodelling and Tissue Repair, Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Univ Paris 6, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Vandermeersch","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Langui","sequence":"additional","affiliation":[{"name":"Plateforme d'imagerie cellulaire Piti\u00e9-Salp\u00eatri\u00e8re, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche_S1127\/Centre r\u00e9gional de la Recherche Scientifique Unit\u00e9 Mixte de Recherche_7225\/Universit\u00e9 Pierre et Marie Curie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Daudon","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"},{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Univ Paris 6, Paris, France;"},{"name":"Explorations fonctionnelles multidisciplinaires, H\u00f4pital Tenon, Assistance Publique \u2013 H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Frochot","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche_S1155, Rare and Common Kidney Diseases, Matrix Remodeling and Tissue Repair, Paris, France;"},{"name":"Explorations fonctionnelles multidisciplinaires, H\u00f4pital Tenon, 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