{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:11:52Z","timestamp":1793016712739,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    Increased urine albumin excretion is highly prevalent in Hispanics\/Latinos. Previous studies have found an association between urine albumin excretion and Amerindian ancestry in Hispanic\/Latino populations. Admixture between racial\/ethnic groups creates long-range linkage disequilibrium between variants with different allelic frequencies in the founding populations and it can be used to localize genes. Hispanic\/Latino genomes are an admixture of European, African, and Amerindian ancestries. We leveraged this admixture to identify associations between urine albumin excretion (urine albumin-to-creatinine ratio [UACR]) and genomic regions harboring variants with highly differentiated allele frequencies among the ancestral populations. Admixture mapping analysis of 12,212 Hispanic Community Health Study\/Study of Latinos participants, using a linear mixed model, identified three novel genome-wide significant signals on chromosomes 2, 11, and 16. The admixture mapping signal identified on chromosome 2, spanning q11.2\u201314.1 and not previously reported for UACR, is driven by a difference between Amerindian ancestry and the other two ancestries (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;5.7 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ). Within this locus, two common variants located at the proapoptotic\n                    <jats:italic toggle=\"yes\">BCL2L11<\/jats:italic>\n                    gene associated with UACR: rs116907128 (allele frequency =0.14;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =1.5 \u00d7 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    ) and rs586283 (C allele frequency =0.35;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =4.2 \u00d7 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    ). In a secondary analysis, rs116907128 accounted for most of the admixture mapping signal observed in the region. The rs116907128 variant is common among full-heritage Pima Indians (A allele frequency =0.54) but is monomorphic in the 1000 Genomes European and African populations. In a replication analysis using a sample of full-heritage Pima Indians, rs116907128 significantly associated with UACR (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.01;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =1568). Our findings provide evidence for the presence of Amerindian-specific variants influencing the variation of urine albumin excretion in Hispanics\/Latinos.\n                  <\/jats:p>","DOI":"10.1681\/asn.2016091010","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T21:10:32Z","timestamp":1485810632000},"page":"2211-2220","source":"Crossref","is-referenced-by-count":45,"title":["Admixture Mapping Identifies an Amerindian Ancestry Locus Associated with Albuminuria in Hispanics in the United States"],"prefix":"10.1681","volume":"28","author":[{"given":"Lisa A.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne M.","family":"Stilp","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie J.","family":"Baier","sequence":"additional","affiliation":[{"name":"Epidemiology and Clinical Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly J.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences and Medicine, Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Masindova","sequence":"additional","affiliation":[{"name":"Epidemiology and Clinical Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Levy","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, Massachusetts, and Population Sciences Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Epidemiology and Clinical Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley E.","family":"Moncrieft","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Miami, Miami, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia E.","family":"Rosas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Lash","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology and Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Cai","sequence":"additional","affiliation":[{"name":"Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy C.","family":"Laurie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Browning","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"B1-20230829","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1001\/jama.286.4.421","article-title":"Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals.","volume":"286","author":"Gerstein","year":"2001","journal-title":"JAMA"},{"key":"B2-20230829","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ki.2010.550","article-title":"Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. 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