{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:43:35Z","timestamp":1786553015696,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    The mucoprotein uromodulin is the most abundant protein in mammalian urine and has important roles in ion transport, maintenance of water and electrolyte balance, and clearance of bacteria from the urinary tract. Low urinary uromodulin concentrations have been associated with increased mortality risk. However, measuring uromodulin in urine has several preanalytic drawbacks, and sensitive assays for the detection of uromodulin in blood have become available. In this study, we investigated the association of serum uromodulin concentration with cardiovascular biomarkers and mortality risk in a large cohort of patients referred for coronary angiography. Uromodulin concentrations were available in 3057 of 3316 participants of the Ludwigshafen Risk and Cardiovascular Health Study. Higher serum uromodulin concentration associated with a favorable metabolic profile, lower prevalence rates of comorbidities (arterial hypertension, diabetes mellitus, and heart failure), and a lower risk for 10-year mortality, with hazard ratios (95% confidence intervals) of 0.65 (0.54 to 0.78), 0.71 (0.58 to 0.88), and 0.57 (0.45 to 0.73) in the second, third, and fourth quartiles, respectively, compared with the first quartile. The association with reduced mortality was independent of other cardiovascular risk factors, including eGFR, and stronger after adjustment for the genotype of the rs12917707 polymorphism at the\n                    <jats:italic toggle=\"yes\">UMOD<\/jats:italic>\n                    locus. Adding serum uromodulin concentration to established cardiovascular risk prediction scores improved risk prediction. Uromodulin may, therefore, be a useful marker for cardiovascular and renal health.\n                  <\/jats:p>","DOI":"10.1681\/asn.2016111162","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T20:25:31Z","timestamp":1488227131000},"page":"2201-2210","source":"Crossref","is-referenced-by-count":82,"title":["Serum Uromodulin and Mortality Risk in Patients Undergoing Coronary Angiography"],"prefix":"10.1681","volume":"28","author":[{"given":"Graciela E.","family":"Delgado","sequence":"first","affiliation":[{"name":"Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus E.","family":"Kleber","sequence":"additional","affiliation":[{"name":"Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;"},{"name":"Competence Cluster of Nutrition and Cardiovascular Health, Halle-Jena-Leipzig, Leipzig, Germany;"},{"name":"Department of Nutritional Biochemistry and Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Scharnagl","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard K.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"M\u00e4rz","sequence":"additional","affiliation":[{"name":"Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;"},{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria;"},{"name":"Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen E.","family":"Scherberich","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Clinical Immunology, Klinikum Muenchen-Harlaching, Teaching Hospital of the Ludwig-Maximilians University, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"B2-20230829","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0021-9258(18)71101-0","article-title":"Direct visualization of a mucoprotein component of urine.","volume":"212","author":"Porter","year":"1955","journal-title":"J Biol Chem"},{"key":"B4-20230829","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000077600","article-title":"Urinary excretion rate of Tamm-Horsfall protein is related to salt intake in humans.","volume":"97","author":"Torffvit","year":"2004","journal-title":"Nephron Physiol"},{"key":"B5-20230829","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.1074\/jbc.M008610200","article-title":"Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors.","volume":"276","author":"Pak","year":"2001","journal-title":"J Biol Chem"},{"key":"B6-20230829","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1523-1755.2004.00452.x","article-title":"Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: Rapid communication.","volume":"65","author":"Bates","year":"2004","journal-title":"Kidney Int"},{"key":"B7-20230829","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI200522720","article-title":"Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism.","volume":"115","author":"S\u00e4emann","year":"2005","journal-title":"J Clin Invest"},{"key":"B8-20230829","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ki.2015.192","article-title":"Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults.","volume":"88","author":"Garimella","year":"2015","journal-title":"Kidney Int"},{"key":"B9-20230829","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/00365590701644691","article-title":"Decreased urinary concentration of Tamm-Horsfall protein is associated with development of renal failure and cardiovascular death within 20 years in type 1 but not in type 2 diabetic patients.","volume":"42","author":"Sejdiu","year":"2008","journal-title":"Scand J Urol Nephrol"},{"key":"B10-20230829","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease.","volume":"41","author":"K\u00f6ttgen","year":"2009","journal-title":"Nat Genet"},{"key":"B11-20230829","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1681\/ASN.2009070725","article-title":"Uromodulin levels associate with a common UMOD variant and risk for incident CKD.","volume":"21","author":"K\u00f6ttgen","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"B12-20230829","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1681\/ASN.2013070781","article-title":"Common variants in UMOD associate with urinary uromodulin levels: A meta-analysis.","volume":"25","author":"Olden","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"B13-20230829","doi-asserted-by":"crossref","first-page":"e1001177","DOI":"10.1371\/journal.pgen.1001177","article-title":"Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.","volume":"6","author":"Padmanabhan","year":"2010","journal-title":"PLoS Genet"},{"key":"B14-20230829","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1097\/HJH.0b013e328349de25","article-title":"Uromodulin gene variant is associated with type 2 diabetic nephropathy.","volume":"29","author":"Ahluwalia","year":"2011","journal-title":"J Hypertens"},{"key":"B15-20230829","article-title":"Serum uromodulin - a marker of kidney function and renal parenchymal integrity [published online ahead of print February 16, 2017]","author":"Scherberich","journal-title":"Nephrol Dial Transplant"},{"key":"B17-20230829","doi-asserted-by":"crossref","first-page":"e3011","DOI":"10.1097\/MD.0000000000003011","article-title":"Plasma uromodulin correlates with kidney function and identifies early stages in chronic kidney disease patients.","volume":"95","author":"Steubl","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"25 Pt B","key":"B18-20230829","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American college of cardiology\/American heart association task force on practice guidelines.","volume":"63","author":"Stone","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"B19-20230829","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0735-1097(01)01360-2","article-title":"Long-term risk stratification for survivors of acute coronary syndromes. Results from the long-term intervention with pravastatin in ischemic disease (LIPID) study.","volume":"38","author":"Marschner","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"B20-20230829","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1093\/eurheartj\/ehs164","article-title":"Routinely available biomarkers improve prediction of long-term mortality in stable coronary artery disease: The Vienna and Ludwigshafen coronary artery disease (VILCAD) risk score.","volume":"33","author":"Goliasch","year":"2012","journal-title":"Eur Heart J"},{"key":"B21-20230829","doi-asserted-by":"crossref","first-page":"30200","DOI":"10.1074\/jbc.M111.222968","article-title":"Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner.","volume":"286","author":"Mutig","year":"2011","journal-title":"J Biol Chem"},{"key":"B22-20230829","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1681\/ASN.2015070830","article-title":"The uromodulin gene locus shows evidence of pathogen adaptation through human evolution.","volume":"27","author":"Ghirotto","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B23-20230829","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ndt\/gft345","article-title":"Determination of uromodulin in human urine: Influence of storage and processing.","volume":"29","author":"Youhanna","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"Suppl 1","key":"B24-20230829","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1517\/14622416.2.1.S1","article-title":"Rationale and design of the LURIC study--a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease.","volume":"2","author":"Winkelmann","year":"2001","journal-title":"Pharmacogenomics"},{"key":"B25-20230829","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1114248","article-title":"Estimating glomerular filtration rate from serum creatinine and cystatin C.","volume":"367","author":"Inker","year":"2012","journal-title":"N Engl J Med"},{"key":"B26-20230829","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/ki.2013.243","article-title":"Comments on \u2018KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.\u2019","volume":"84","author":"Andrassy","year":"2013","journal-title":"Kidney Int"},{"key":"B27-20230829","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"B28-20230829","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201707000-00026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:28:49Z","timestamp":1786130929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201707000-00026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2016111162","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]}}}