{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:13Z","timestamp":1790107993951,"version":"4.0.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n                    Biopsy findings at the time of procurement of deceased donor kidneys remain the most common reason cited for kidney discard. To determine the value of renal allograft histology in predicting outcomes, we evaluated the significance of histologic findings, read by experienced renal pathologists, in 975 postreperfusion biopsy specimens collected from 2005 to 2009 after living donor (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =427) or deceased donor (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =548) renal transplant. We evaluated specimens for the degree of glomerulosclerosis, interstitial fibrosis and tubular atrophy, and vascular disease; specimens with a score of 0 or 1 (scale, 0\u20133) for each parameter were considered optimal. Overall, 66.3% of living donor kidneys and 50.7% of deceased donor kidneys received an optimal histology score (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001). Irrespective of donor status, suboptimal kidneys came from older donors with a higher incidence of diabetes mellitus, hypertension, and obesity and a higher mean kidney donor risk index (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001). Death-censored outcomes after transplant differed significantly between optimal and suboptimal kidneys only in the deceased donor transplants (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.02). Regardless of histologic classification, outcomes with deceased donor kidneys were inferior to outcomes with living donor kidneys. However, 73.2% of deceased donor kidneys with suboptimal histology remained functional at 5 years. Our findings suggest that histologic findings on postreperfusion biopsy associate with outcomes after deceased donor but not living donor renal transplants, thus donor death and organ preservation\u2013related factors may be of greater prognostic importance. Discarding donated kidneys on the basis of histologic factors may be inappropriate and merits further study.\n                  <\/jats:p>","DOI":"10.1681\/asn.2016121330","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T20:30:27Z","timestamp":1499373027000},"page":"3109-3117","source":"Crossref","is-referenced-by-count":50,"title":["Association between Reperfusion Renal Allograft Biopsy Findings and Transplant Outcomes"],"prefix":"10.1681","volume":"28","author":[{"given":"Sumit","family":"Mohan","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, New York;"},{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Campenot","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana C.","family":"Chiles","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick","family":"Santoriello","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bland","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. John","family":"Crew","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rosenstiel","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Dube","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Batal","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Rodrigo","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Surgery, Columbia University College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Guarrera","sequence":"additional","affiliation":[{"name":"Surgery, Columbia University College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Barry","family":"Stokes","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivette","family":"D\u2019Agati","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd E.","family":"Ratner","sequence":"additional","affiliation":[{"name":"Surgery, Columbia University College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Pathology 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