{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:02:49Z","timestamp":1786132969941,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>\n                    Lupus nephritis (LN) is one of the most prevalent and serious complications of SLE, with significant effects on patient and renal survival. Although a large number of genetic variants associated with SLE have been identified, biomarkers that correlate with LN are extremely limited. In this study, we performed a comprehensive sequencing analysis of the whole MHC region in 1331 patients with LN and 1296 healthy controls and validated the independent associations in another 950 patients with LN and 1000 controls. We discovered five independent risk variants for LN within the MHC region, including\n                    <jats:italic toggle=\"yes\">HLA-DR\u03b21<\/jats:italic>\n                    amino acid 11 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    <jats:sub>omnibus<\/jats:sub>\n                    &lt;0.001),\n                    <jats:italic toggle=\"yes\">HLA-DQ\u03b21<\/jats:italic>\n                    amino acid 45 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65),\n                    <jats:italic toggle=\"yes\">HLA-A<\/jats:italic>\n                    amino acid 156 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    <jats:sub>omnibus<\/jats:sub>\n                    &lt;0.001),\n                    <jats:italic toggle=\"yes\">HLA-DP\u03b21<\/jats:italic>\n                    amino acid 76 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    <jats:sub>omnibus<\/jats:sub>\n                    &lt;0.001), and a missense variant in\n                    <jats:italic toggle=\"yes\">PRRC2A<\/jats:italic>\n                    (rs114580964;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt;0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance. These data implicate aberrant peptide presentation by MHC classes 1 and 2 molecules and sex hormone modulation in the development of LN.\n                  <\/jats:p>","DOI":"10.1681\/asn.2016121331","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T20:25:16Z","timestamp":1501273516000},"page":"3383-3394","source":"Crossref","is-referenced-by-count":23,"title":["Association Analysis of the MHC in Lupus Nephritis"],"prefix":"10.1681","volume":"28","author":[{"given":"Ricong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"},{"name":"Department of Nephrology, Shenzhen Second People\u2019s Hospital and the First Affiliated Hospital of Shenzhen University, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Li","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"},{"name":"Nephrology and Rheumatology Department, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Shen","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Peking University, Institute of Nephrology, Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Liao","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhou","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiran","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wu","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou","family":"Wang","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Yang","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbin","family":"Fang","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Third Affiliated Hospital and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The People\u2019s Hospital of Guangxi Autonomous Region, Nanning, Guangxi, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lie","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Guangdong Medical University, Zhanjiang, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangsuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxia","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Second Hospital, Hebei Medical University, Shijiazhuang, Hebei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangdan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, No. 1 Hospital and"},{"name":"Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University, Hefei, Anhui, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University, Hefei, Anhui, China;"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanming","family":"Yang","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"},{"name":"James D. Watson Institute of Genome Sciences, Hangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"},{"name":"James D. Watson Institute of Genome Sciences, Hangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"},{"name":"Institute of Dermatology and Department of Dermatology, No. 1 Hospital and"},{"name":"Department of Biology, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology, No. 1 Hospital and"},{"name":"School of Biological Sciences, Anhui Medical University, Hefei, Anhui, China;"},{"name":"Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingrui","family":"Li","sequence":"additional","affiliation":[{"name":"BGI Genomics, BGI-Shenzhen, Shenzhen, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China;"},{"name":"Institute of Nephrology, Guangdong Medical University, Zhanjiang, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"B1-20231016","first-page":"849684","article-title":"Lupus nephritis: An overview of recent findings.","volume":"2012","author":"de Zubiria Salgado","year":"2012","journal-title":"Autoimmune Dis"},{"key":"B2-20231016","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/0961203309358187","article-title":"Review: Lupus nephritis: Pathologic features, epidemiology and a guide to therapeutic decisions.","volume":"19","author":"Ortega","year":"2010","journal-title":"Lupus"},{"key":"B3-20231016","doi-asserted-by":"crossref","first-page":"638413","DOI":"10.1155\/2010\/638413","article-title":"Biomarkers for lupus nephritis: A critical appraisal.","volume":"2010","author":"Mok","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"B4-20231016","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/01.bor.0000174182.70159.22","article-title":"Biomarkers for systemic lupus erythematosus: A review and perspective.","volume":"17","author":"Liu","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"B5-20231016","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ajhg.2012.11.018","article-title":"Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.","volume":"92","author":"Yang","year":"2013","journal-title":"Am J Hum Genet"},{"key":"B6-20231016","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.","volume":"41","author":"Gateva","year":"2009","journal-title":"Nat Genet"},{"key":"B7-20231016","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ng.81","article-title":"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.","volume":"40","author":"Harley","year":"2008","journal-title":"Nat Genet"},{"key":"B8-20231016","doi-asserted-by":"crossref","first-page":"e1001323","DOI":"10.1371\/journal.pgen.1001323","article-title":"Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.","volume":"7","author":"Chung","year":"2011","journal-title":"PLoS Genet"},{"key":"B9-20231016","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa0707865","article-title":"Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.","volume":"358","author":"Hom","year":"2008","journal-title":"N Engl J Med"},{"key":"B10-20231016","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/ng.200","article-title":"Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.","volume":"40","author":"Graham","year":"2008","journal-title":"Nat Genet"},{"key":"B11-20231016","doi-asserted-by":"crossref","first-page":"e1002455","DOI":"10.1371\/journal.pgen.1002455","article-title":"A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.","volume":"8","author":"Okada","year":"2012","journal-title":"PLoS Genet"},{"key":"B12-20231016","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng.472","article-title":"Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.","volume":"41","author":"Han","year":"2009","journal-title":"Nat Genet"},{"key":"B13-20231016","doi-asserted-by":"crossref","first-page":"e1000841","DOI":"10.1371\/journal.pgen.1000841","article-title":"Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.","volume":"6","author":"Yang","year":"2010","journal-title":"PLoS Genet"},{"key":"B14-20231016","doi-asserted-by":"crossref","first-page":"e1000696","DOI":"10.1371\/journal.pgen.1000696","article-title":"High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.","volume":"5","author":"Barcellos","year":"2009","journal-title":"PLoS Genet"},{"key":"B15-20231016","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ajhg.2012.08.026","article-title":"Unraveling multiple MHC gene associations with systemic lupus erythematosus: Model choice indicates a role for HLA alleles and non-HLA genes in Europeans.","volume":"91","author":"Morris","year":"2012","journal-title":"Am J Hum Genet"},{"key":"B16-20231016","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1038\/ncomms6902","article-title":"The HLA-DR\u03b21 amino acid positions 11-13-26 explain the majority of SLE-MHC associations.","volume":"5","author":"Kim","year":"2014","journal-title":"Nat Commun"},{"key":"B17-20231016","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1093\/hmg\/ddu149","article-title":"Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations.","volume":"23","author":"Pillai","year":"2014","journal-title":"Hum Mol Genet"},{"key":"B18-20231016","doi-asserted-by":"crossref","first-page":"e69388","DOI":"10.1371\/journal.pone.0069388","article-title":"An integrated tool to study MHC region: Accurate SNV detection and HLA genes typing in human MHC region using targeted high-throughput sequencing.","volume":"8","author":"Cao","year":"2013","journal-title":"PLoS One"},{"key":"B19-20231016","doi-asserted-by":"crossref","first-page":"18680","DOI":"10.1073\/pnas.0909307106","article-title":"Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.","volume":"106","author":"Rioux","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B20-20231016","doi-asserted-by":"crossref","first-page":"e192","DOI":"10.1371\/journal.pgen.0030192","article-title":"Identification of two independent risk factors for lupus within the MHC in United Kingdom families.","volume":"3","author":"Fernando","year":"2007","journal-title":"PLoS Genet"},{"key":"B21-20231016","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/annrheumdis-2011-200808","article-title":"Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G.","volume":"71","author":"Fernando","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"B22-20231016","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1002\/art.27658","article-title":"Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.","volume":"62","author":"Clancy","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B23-20231016","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0272-6386(12)70258-5","article-title":"Lupus anticoagulant in systemic lupus erythematosus: A clinical and renal pathological study.","volume":"20","author":"Farrugia","year":"1992","journal-title":"Am J Kidney Dis"},{"key":"B24-20231016","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1002\/1529-0131(200110)44:10<2350::AID-ART398>3.0.CO;2-A","article-title":"A decrease in complement is associated with increased renal and hematologic activity in patients with systemic lupus erythematosus.","volume":"44","author":"Ho","year":"2001","journal-title":"Arthritis Rheum"},{"key":"B25-20231016","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat Genet"},{"key":"B26-20231016","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ajhg.2014.02.013","article-title":"Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.","volume":"94","author":"Han","year":"2014","journal-title":"Am J Hum Genet"},{"key":"B27-20231016","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/ng.3353","article-title":"Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.","volume":"47","author":"Hu","year":"2015","journal-title":"Nat Genet"},{"key":"B28-20231016","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajhg.2013.05.020","article-title":"Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk.","volume":"93","author":"Foo","year":"2013","journal-title":"Am J Hum Genet"},{"key":"B29-20231016","doi-asserted-by":"crossref","first-page":"e0126564","DOI":"10.1371\/journal.pone.0126564","article-title":"Novel autoantigens associated with lupus nephritis.","volume":"10","author":"Onishi","year":"2015","journal-title":"PLoS One"},{"key":"B30-20231016","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ng0209-139","article-title":"A supersized list of obesity genes.","volume":"41","author":"Hofker","year":"2009","journal-title":"Nat Genet"},{"key":"B31-20231016","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrendo.2013.212","article-title":"Endocrine autoimmune diseases and female infertility.","volume":"10","author":"Sen","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"B32-20231016","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/ng.1051","article-title":"Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.","volume":"44","author":"Stolk","year":"2012","journal-title":"Nat Genet"},{"key":"B33-20231016","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.4238\/2012.September.17.1","article-title":"Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population.","volume":"11","author":"Pan","year":"2012","journal-title":"Genet Mol Res"},{"key":"B34-20231016","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s004399900100","article-title":"Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus.","volume":"105","author":"Hashimoto","year":"1999","journal-title":"Hum Genet"},{"key":"B35-20231016","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus.","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum"},{"key":"B36-20231016","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.ASN.0000108969.21691.5D","article-title":"The classification of glomerulonephritis in systemic lupus erythematosus revisited.","volume":"15","author":"Weening","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"B37-20231016","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/humu.22439","article-title":"A short-read multiplex sequencing method for reliable, cost-effective and high-throughput genotyping in large-scale studies.","volume":"34","author":"Cao","year":"2013","journal-title":"Hum Mutat"},{"key":"B38-20231016","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1084\/jem.188.8.1511","article-title":"Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.","volume":"188","author":"Smith","year":"1998","journal-title":"J Exp Med"},{"key":"B39-20231016","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ajhg.2013.11.005","article-title":"Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes.","volume":"93","author":"Lohmueller","year":"2013","journal-title":"Am J Hum Genet"},{"key":"B40-20231016","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform.","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"B41-20231016","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/gepi.20579","article-title":"Evaluating the heritability explained by known susceptibility variants: A survey of ten complex diseases.","volume":"35","author":"So","year":"2011","journal-title":"Genet Epidemiol"},{"key":"B42-20231016","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1186\/ar2368","article-title":"Rheumatic diseases in China.","volume":"10","author":"Zeng","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"B43-20231016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20100725","article-title":"A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.","volume":"208","author":"Sethi","year":"2011","journal-title":"J Exp Med"},{"key":"B44-20231016","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0022-2836(91)90567-P","article-title":"Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution.","volume":"219","author":"Saper","year":"1991","journal-title":"J Mol Biol"},{"key":"B45-20231016","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis.","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201711000-00029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:26:46Z","timestamp":1786130806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201711000-00029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2016121331","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}