{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:58:21Z","timestamp":1791428301534,"version":"4.3.3"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,9]]},"abstract":"\n The appropriate target for BP in patients with CKD and hypertension remains uncertain. We report prespecified subgroup analyses of outcomes in participants with baseline CKD in the Systolic Blood Pressure Intervention Trial. We randomly assigned participants to a systolic BP target of <120 mm Hg (intensive group;\n n<\/jats:italic>\n =1330) or <140 mm Hg (standard group;\n n<\/jats:italic>\n =1316). After a median follow-up of 3.3 years, the primary composite cardiovascular outcome occurred in 112 intensive group and 131 standard group CKD participants (hazard ratio [HR], 0.81; 95% confidence interval [95% CI], 0.63 to 1.05). The intensive group also had a lower rate of all-cause death (HR, 0.72; 95% CI, 0.53 to 0.99). Treatment effects did not differ between participants with and without CKD (\n P<\/jats:italic>\n values for interactions \u22650.30). The prespecified main kidney outcome, defined as the composite of \u226550% decrease in eGFR from baseline or ESRD, occurred in 15 intensive group and 16 standard group participants (HR, 0.90; 95% CI, 0.44 to 1.83). After the initial 6 months, the intensive group had a slightly higher rate of change in eGFR (\u22120.47 versus \u22120.32 ml\/min per 1.73 m\n 2<\/jats:sup>\n per year;\n P<\/jats:italic>\n <0.03). The overall rate of serious adverse events did not differ between treatment groups, although some specific adverse events occurred more often in the intensive group. Thus, among patients with CKD and hypertension without diabetes, targeting an SBP<120 mm Hg compared with <140 mm Hg reduced rates of major cardiovascular events and all-cause death without evidence of effect modifications by CKD or deleterious effect on the main kidney outcome.\n <\/jats:p>","DOI":"10.1681\/asn.2017020148","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T20:30:27Z","timestamp":1498163427000},"page":"2812-2823","source":"Crossref","is-referenced-by-count":465,"title":["Effects of Intensive BP Control in CKD"],"prefix":"10.1681","volume":"28","author":[{"given":"Alfred K.","family":"Cheung","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension and"},{"name":"Medical Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboob","family":"Rahman","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center, Case Western Reserve University Hospitals, Cleveland, Ohio;"},{"name":"Department of Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Reboussin","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"Craven","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Kimmel","sequence":"additional","affiliation":[{"name":"Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Cushman","sequence":"additional","affiliation":[{"name":"Hypertension Section, Medical Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amret T.","family":"Hawfield","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Nephrology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Oparil","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Rocco","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Nephrology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaycee M.","family":"Sink","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Whelton","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson T.","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center, Case Western Reserve University Hospitals, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical University of South Carolina, Charleston, South Carolina;"},{"name":"Primary Care Research, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Beddhu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension and"},{"name":"Medical Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayan","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Ohio State University Medical Center, Columbus, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara I.","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn M.","family":"Chertow","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Chonchol","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry I.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Nephrology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Haley","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic Florida, Jacksonville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Nephrology-Hypertension, Department of Medicine, University of 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