{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:50:13Z","timestamp":1792198213979,"version":"4.4.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\n                    Atherosclerotic renovascular disease (RVD) reduces renal blood flow (RBF) and GFR and accelerates poststenotic kidney (STK) tissue injury. Preclinical studies indicate that mesenchymal stem cells (MSCs) can stimulate angiogenesis and modify immune function in experimental RVD. We assessed the safety and efficacy of adding intra-arterial autologous adipose-derived MSCs into STK to standardized medical treatment in human subjects without revascularization. The intervention group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =14) received a single infusion of MSC (1.0 \u00d7 10\n                    <jats:sup>5<\/jats:sup>\n                    or 2.5 \u00d7 10\n                    <jats:sup>5<\/jats:sup>\n                    cells\/kg;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =7 each) plus standardized medical treatment; the medical treatment only group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =14) included subjects matched for age, kidney function, and stenosis severity. We measured cortical and medullary volumes, perfusion, and RBF using multidetector computed tomography. We assessed tissue oxygenation by blood oxygen level\u2013dependent MRI and GFR by iothalamate clearance. MSC infusions were well tolerated. Three months after infusion, cortical perfusion and RBF rose in the STK (151.8\u2013185.5 ml\/min,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.01); contralateral kidney RBF increased (212.7\u2013271.8 ml\/min,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.01); and STK renal hypoxia (percentage of the whole kidney with R2*&gt;30\/s) decreased (12.1% [interquartile range, 3.3%\u201317.8%] to 6.8% [interquartile range, 1.8%\u201312.9%],\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.04). No changes in RBF occurred in medical treatment only subjects. Single-kidney GFR remained stable after MSC but fell in the medical treatment only group (\u22123% versus \u221224%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.04). This first-in-man dose-escalation study provides evidence of safety of intra-arterial infusion of autologous MSCs in patients with RVD. MSC infusion without main renal artery revascularization associated with increased renal tissue oxygenation and cortical blood flow.\n                  <\/jats:p>","DOI":"10.1681\/asn.2017020151","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T20:11:13Z","timestamp":1493669473000},"page":"2777-2785","source":"Crossref","is-referenced-by-count":155,"title":["Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease"],"prefix":"10.1681","volume":"28","author":[{"given":"Ahmed","family":"Saad","sequence":"first","affiliation":[{"name":"Divisions of*Nephrology and Hypertension and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Dietz","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra M.S.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Divisions of*Nephrology and Hypertension and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaTonya J.","family":"Hickson","sequence":"additional","affiliation":[{"name":"Divisions of*Nephrology and Hypertension and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Glockner","sequence":"additional","affiliation":[{"name":"Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"McKusick","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Misra","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haraldur","family":"Bjarnason","sequence":"additional","affiliation":[{"name":"Interventional Radiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Gastineau","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Divisions of*Nephrology and Hypertension and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Textor","sequence":"additional","affiliation":[{"name":"Divisions of*Nephrology and Hypertension and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"B1-20230819","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1148\/radiol.13122234","article-title":"Human renovascular 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