{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:00:41Z","timestamp":1786132841724,"version":"build-2736575974"},"reference-count":73,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\n                    Collecting ducts make up the distal-most tubular segments of the kidney, extending from the cortex, where they connect to the nephron proper, into the medulla, where they release urine into the renal pelvis. During water deprivation, body water preservation is ensured by the selective transepithelial reabsorption of water into the hypertonic medullary interstitium mediated by collecting ducts. The collecting duct epithelium forms tight junctions composed of barrier-enforcing claudins and exhibits a higher transepithelial resistance than other segments of the renal tubule exhibit. However, the functional relevance of this strong collecting duct epithelial barrier is unresolved. Here, we report that collecting duct\u2013specific deletion of an epithelial transcription factor, grainyhead-like 2 (GRHL2), in mice led to reduced expression of tight junction\u2013associated barrier components, reduced collecting duct transepithelial resistance, and defective renal medullary accumulation of sodium and other osmolytes.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Grhl2<\/jats:italic>\n                    -deficient collecting duct cells displayed increased paracellular flux of sodium, chloride, and urea. Consistent with these effects,\n                    <jats:italic toggle=\"yes\">Grhl2<\/jats:italic>\n                    -deficient mice had diabetes insipidus, produced dilute urine, and failed to adequately concentrate their urine after water restriction, resulting in susceptibility to prerenal azotemia. These data indicate a direct functional link between collecting duct epithelial barrier characteristics, which appear to prevent leakage of interstitial osmolytes into urine, and body water homeostasis.\n                  <\/jats:p>","DOI":"10.1681\/asn.2017030353","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T10:25:19Z","timestamp":1513160719000},"page":"857-868","source":"Crossref","is-referenced-by-count":25,"title":["GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation"],"prefix":"10.1681","volume":"29","author":[{"given":"Christian","family":"Hinze","sequence":"first","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;"},{"name":"Berlin Institute of Health, Berlin, Germany;"},{"name":"Nephrology and Medical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janett","family":"Ruffert","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;"},{"name":"Berlin Institute of Urologic Research, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Walentin","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Himmerkus","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Christian Albrechts University Kiel, Kiel, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Nikpey","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway;"},{"name":"Department of Medicine, Haukeland University Hospital, Bergen, Norway; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Tenstad","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Wiig","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerim","family":"Mutig","sequence":"additional","affiliation":[{"name":"Anatomy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha Yesim","family":"Yurtdas","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;"},{"name":"Berlin Institute of Urologic Research, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet D.","family":"Klein","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9822-0607","authenticated-orcid":false,"given":"Jeff M.","family":"Sands","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Branchi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9 Universit\u00e4tsmedizin, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schumann","sequence":"additional","affiliation":[{"name":"Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9 Universit\u00e4tsmedizin, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Anatomy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Bleich","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Christian Albrechts University Kiel, Kiel, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-7142","authenticated-orcid":false,"given":"Kai M.","family":"Schmidt-Ott","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;"},{"name":"Nephrology and Medical Intensive 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