{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:00:41Z","timestamp":1792548041966,"version":"4.5.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    The Wnt\/\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin pathway is crucial in normal development and throughout life, but aberrant activation of this pathway has been linked to kidney fibrosis, although the mechanisms involved remain incompletely determined. Here, we investigated the role of Wnt\/\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin in regulating macrophage activation and the contribution thereof to kidney fibrosis. Treatment of macrophages with Wnt3a exacerbated IL-4\u2013 or TGF\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1-induced macrophage alternative (M2) polarization and the phosphorylation and nuclear translocation of STAT3\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . Conversely, inhibition of Wnt\/\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin signaling prevented these IL-4\u2013 or TGF\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    1-induced processes. In a mouse model, induced deletion of\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin in macrophages attenuated the fibrosis, macrophage accumulation, and M2 polarization observed in the kidneys of wild-type littermates after unilateral ureter obstruction. This study shows that activation of Wnt\/\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -catenin signaling promotes kidney fibrosis by stimulating macrophage M2 polarization.\n                  <\/jats:p>","DOI":"10.1681\/asn.2017040391","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T20:40:24Z","timestamp":1507754424000},"page":"182-193","source":"Crossref","is-referenced-by-count":258,"title":["Wnt\/\u03b2-Catenin\u2013Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis"],"prefix":"10.1681","volume":"29","author":[{"given":"Ye","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafa","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyan","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"B1-20230819","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.","volume":"351","author":"Go","year":"2004","journal-title":"N Engl J Med"},{"key":"B2-20230819","doi-asserted-by":"crossref","first-page":"c269","DOI":"10.1159\/000321382","article-title":"The burden of chronic kidney disease on developing nations: A 21st century challenge in global health.","volume":"118","author":"Nugent","year":"2011","journal-title":"Nephron Clin Pract"},{"key":"B3-20230819","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1172\/JCI36150","article-title":"Macrophage diversity in renal injury and repair.","volume":"118","author":"Ricardo","year":"2008","journal-title":"J Clin Invest"},{"key":"B4-20230819","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00467-013-2726-y","article-title":"Macrophage-mediated injury and repair after ischemic kidney injury.","volume":"30","author":"Huen","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"B5-20230819","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.4049\/jimmunol.1402149","article-title":"CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.","volume":"194","author":"Engel","year":"2015","journal-title":"J Immunol"},{"key":"B6-20230819","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneph.2014.170","article-title":"Dendritic cells and macrophages in the kidney: A spectrum of good and evil.","volume":"10","author":"Rogers","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"B7-20230819","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/kisup.2014.4","article-title":"Macrophage heterogeneity, phenotypes, and roles in renal fibrosis.","volume":"4","author":"Cao","year":"2014","journal-title":"Kidney Int Suppl (2011)"},{"key":"B8-20230819","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneph.2014.114","article-title":"Inflammatory processes in renal fibrosis.","volume":"10","author":"Meng","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"B9-20230819","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1681\/ASN.2012050476","article-title":"Rheb\/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.","volume":"24","author":"Jiang","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B10-20230819","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ckj\/sfw096","article-title":"Macrophage in chronic kidney disease.","volume":"9","author":"Guiteras","year":"2016","journal-title":"Clin Kidney J"},{"key":"B11-20230819","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ki.2011.217","article-title":"Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis.","volume":"80","author":"Anders","year":"2011","journal-title":"Kidney Int"},{"key":"B12-20230819","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/ndt\/16.8.1638","article-title":"Local macrophage proliferation correlates with increased renal M-CSF expression in human glomerulonephritis.","volume":"16","author":"Isbel","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"B13-20230819","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ki.2015.295","article-title":"Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury.","volume":"88","author":"Wang","year":"2015","journal-title":"Kidney Int"},{"key":"B14-20230819","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1172\/JCI60363","article-title":"CSF-1 signaling mediates recovery from acute kidney injury.","volume":"122","author":"Zhang","year":"2012","journal-title":"J Clin Invest"},{"key":"B15-20230819","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1681\/ASN.2014111138","article-title":"Differential Ly6C expression after renal ischemia-reperfusion identifies unique macrophage populations.","volume":"27","author":"Clements","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B16-20230819","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: Nomenclature and experimental guidelines.","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B17-20230819","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2741\/2692","article-title":"Macrophage activation and polarization.","volume":"13","author":"Martinez","year":"2008","journal-title":"Front Biosci"},{"key":"B18-20230819","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nri3088","article-title":"Transcriptional regulation of macrophage polarization: Enabling diversity with identity.","volume":"11","author":"Lawrence","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B19-20230819","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/ni.3710","article-title":"Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk.","volume":"18","author":"Piccolo","year":"2017","journal-title":"Nat Immunol"},{"key":"B20-20230819","doi-asserted-by":"crossref","first-page":"10318","DOI":"10.1074\/jbc.M113.526749","article-title":"Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization.","volume":"289","author":"Date","year":"2014","journal-title":"J Biol Chem"},{"key":"B21-20230819","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2172-13-31","article-title":"TGF\u03b2 signaling plays a critical role in promoting alternative macrophage activation.","volume":"13","author":"Gong","year":"2012","journal-title":"BMC Immunol"},{"key":"B22-20230819","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages.","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"B23-20230819","first-page":"183","article-title":"Macrophages in kidney injury, inflammation, and fibrosis.","volume":"30","author":"Cao","year":"2015","journal-title":"Physiology (Bethesda)"},{"key":"B24-20230819","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1189\/jlb.0504288","article-title":"IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal.","volume":"76","author":"Wynes","year":"2004","journal-title":"J Leukoc Biol"},{"key":"B25-20230819","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1681\/ASN.2007050532","article-title":"A new look at platelet-derived growth factor in renal disease.","volume":"19","author":"Floege","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B26-20230819","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1038\/emboj.2012.146","article-title":"Three decades of Wnts: A personal perspective on how a scientific field developed.","volume":"31","author":"Nusse","year":"2012","journal-title":"EMBO J"},{"key":"B27-20230819","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease.","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"B28-20230819","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1126\/science.287.5458.1606","article-title":"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.","volume":"287","author":"Peifer","year":"2000","journal-title":"Science"},{"key":"B29-20230819","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrm3470","article-title":"The complex world of WNT receptor signalling.","volume":"13","author":"Niehrs","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B30-20230819","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: Components, mechanisms, and diseases.","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell"},{"key":"B31-20230819","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/path.4121","article-title":"Wnt signalling in kidney diseases: Dual roles in renal injury and repair.","volume":"229","author":"Kawakami","year":"2013","journal-title":"J Pathol"},{"key":"B32-20230819","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrneph.2015.88","article-title":"Wnt\/\u03b2-catenin signalling and podocyte dysfunction in proteinuric kidney disease.","volume":"11","author":"Zhou","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"B33-20230819","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis.","volume":"7","author":"Liu","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"B34-20230819","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/kisup.2014.16","article-title":"Wnt\/\u03b2-catenin signaling and kidney fibrosis.","volume":"4","author":"Tan","year":"2014","journal-title":"Kidney Int Suppl (2011)"},{"key":"B35-20230819","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/labinvest.2015.153","article-title":"Wnt\/\u03b2-catenin signaling in kidney injury and repair: A double-edged sword.","volume":"96","author":"Zhou","year":"2016","journal-title":"Lab Invest"},{"key":"B36-20230819","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s40139-015-0077-z","article-title":"Key fibrogenic signaling.","volume":"3","author":"He","year":"2015","journal-title":"Curr Pathobiol Rep"},{"key":"B37-20230819","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrneph.2016.54","article-title":"Developmental signalling pathways in renal fibrosis: The roles of Notch, Wnt and Hedgehog.","volume":"12","author":"Edeling","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"B38-20230819","doi-asserted-by":"crossref","first-page":"E80","DOI":"10.3390\/cancers8090080","article-title":"Wnt signaling in cell motility and invasion: Drawing parallels between development and cancer.","volume":"8","author":"Sedgwick","year":"2016","journal-title":"Cancers (Basel)"},{"key":"B39-20230819","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1073\/pnas.102657399","article-title":"beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.","volume":"99","author":"Cheon","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B40-20230819","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1172\/JCI62059","article-title":"\u03b2-Catenin-regulated myeloid cell adhesion and migration determine wound healing.","volume":"124","author":"Amini-Nik","year":"2014","journal-title":"J Clin Invest"},{"key":"B41-20230819","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1165\/rcmb.2016-0147OC","article-title":"Lrp5\/\u03b2-Catenin signaling controls lung macrophage differentiation and inhibits resolution of fibrosis.","volume":"56","author":"Sennello","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B42-20230819","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.diff.2011.08.003","article-title":"The GM-CSF receptor utilizes \u03b2-catenin and Tcf4 to specify macrophage lineage differentiation.","volume":"83","author":"Brown","year":"2012","journal-title":"Differentiation"},{"key":"B43-20230819","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.4049\/jimmunol.1402797","article-title":"Transcription factors STAT6 and KLF4 implement macrophage polarization via the dual catalytic powers of MCPIP.","volume":"194","author":"Kapoor","year":"2015","journal-title":"J Immunol"},{"key":"B44-20230819","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3324\/haematol.2010.027086","article-title":"\u03b2-catenin is constitutively active and increases STAT3 expression\/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.","volume":"96","author":"Anand","year":"2011","journal-title":"Haematologica"},{"key":"B45-20230819","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1128\/MCB.17.9.5307","article-title":"Functional differences between Stat3alpha and Stat3beta.","volume":"17","author":"Schaefer","year":"1997","journal-title":"Mol Cell Biol"},{"key":"B46-20230819","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbrc.2011.10.112","article-title":"STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+\/CD133+ stem cell-like human colon cancer cells.","volume":"416","author":"Lin","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"B47-20230819","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrd4233","article-title":"Can we safely target the WNT pathway?","volume":"13","author":"Kahn","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"B48-20230819","doi-asserted-by":"crossref","first-page":"14309","DOI":"10.1073\/pnas.1001520107","article-title":"Inhibition of Wnt\/beta-catenin\/CREB binding protein (CBP) signaling reverses pulmonary fibrosis.","volume":"107","author":"Henderson","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B49-20230819","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1074\/jbc.M110.174821","article-title":"Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signaling.","volume":"286","author":"Dai","year":"2011","journal-title":"J Biol Chem"},{"key":"B50-20230819","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1254\/jphs.09227FP","article-title":"Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy.","volume":"111","author":"Kitamoto","year":"2009","journal-title":"J Pharmacol Sci"},{"key":"B51-20230819","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ki.2015.119","article-title":"Rictor\/mTORC2 signaling mediates TGF\u03b21-induced fibroblast activation and kidney fibrosis.","volume":"88","author":"Li","year":"2015","journal-title":"Kidney Int"},{"key":"B53-20230819","doi-asserted-by":"crossref","first-page":"23968","DOI":"10.1038\/srep23968","article-title":"Quercetin inhibits fibroblast activation and kidney fibrosis involving the suppression of mammalian target of rapamycin and \u03b2-catenin signaling.","volume":"6","author":"Ren","year":"2016","journal-title":"Sci Rep"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-201801000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:29:54Z","timestamp":1786130994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-201801000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,11]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2017040391","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,11]]}}}