{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:45:00Z","timestamp":1787060700584,"version":"build-2736575974"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    Osmosis drives transcapillary ultrafiltration and water removal in patients treated with peritoneal dialysis. Crystalloid osmosis, typically induced by glucose, relies on dialysate tonicity and occurs through endothelial aquaporin-1 water channels and interendothelial clefts. In contrast, the mechanisms mediating water flow driven by colloidal agents, such as icodextrin, and combinations of osmotic agents have not been evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    We used experimental models of peritoneal dialysis in mouse and biophysical studies combined with mathematical modeling to evaluate the mechanisms of colloid versus crystalloid osmosis across the peritoneal membrane and to investigate the pathways mediating water flow generated by the glucose polymer icodextrin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    <jats:italic toggle=\"yes\">In silico<\/jats:italic>\n                    modeling and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    studies showed that deletion of aquaporin-1 did not influence osmotic water transport induced by icodextrin but did affect that induced by crystalloid agents. Water flow induced by icodextrin was dependent upon the presence of large, colloidal fractions, with a reflection coefficient close to unity, a low diffusion capacity, and a minimal effect on dialysate osmolality. Combining crystalloid and colloid osmotic agents in the same dialysis solution strikingly enhanced water and sodium transport across the peritoneal membrane, improving ultrafiltration efficiency over that obtained with either type of agent alone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    These data cast light on the molecular mechanisms involved in colloid versus crystalloid osmosis and characterize novel osmotic agents. Dialysis solutions combining crystalloid and colloid particles may help restore fluid balance in patients treated with peritoneal dialysis.\n                  <\/jats:p>","DOI":"10.1681\/asn.2017080828","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T10:30:25Z","timestamp":1527589825000},"page":"1875-1886","source":"Crossref","is-referenced-by-count":65,"title":["Mechanisms of Crystalloid versus Colloid Osmosis across the Peritoneal Membrane"],"prefix":"10.1681","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-1989","authenticated-orcid":false,"given":"Johann","family":"Morelle","sequence":"first","affiliation":[{"name":"Division of Nephrology and"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Sow","sequence":"additional","affiliation":[{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Andr\u00e9","family":"Fustin","sequence":"additional","affiliation":[{"name":"Bio and Soft Matter Division (BSMA), Institute of Condensed Mater and Nanosciences, Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fill\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Cliniques Universitaires Saint-Luc, Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvia","family":"Garcia-Lopez","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Goffin","sequence":"additional","affiliation":[{"name":"Division of Nephrology and"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9deric","family":"Vandemaele","sequence":"additional","affiliation":[{"name":"Baxter Healthcare, Braine-l\u2019Alleud, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Rippe","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Lund University, Skane University Hospital, Lund, Sweden; 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