{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:49:28Z","timestamp":1790254168889,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    The development of antibodies specific to HLA expressed on donor tissue (donor-specific antibodies [DSAs]) is a prominent risk factor for kidney graft loss. Non-HLA antibodies with pathogenic potential have also been described, including natural antibodies (Nabs). These IgG Nabs bind to immunogenic self-determinants, including oxidation-related antigens.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    To examine the relationship of Nabs with graft outcomes, we assessed Nabs in blinded serum specimens collected from a retrospective cohort of 635 patients who received a transplant between 2005 and 2010 at Necker Hospital in Paris, France. Serum samples were obtained immediately before transplant and at the time of biopsy-proven rejection within the first year or 1 year after transplant. Nabs were detected by ELISA through reactivity to the generic oxidized epitope malondialdehyde.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    Univariate Cox regression analysis identified the development of post-transplant Nabs (defined as 50% increase in reactivity to malondialdehyde) as a significant risk factor for graft loss (hazard ratio, 2.68; 95% confidence interval, 1.49 to 4.82;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.001). Post-transplant Nabs also correlated with increased mean Banff scores for histologic signs of graft injury in post-transplant biopsy specimens. Multivariable Cox analyses confirmed Nabs development as a risk factor independent from anti-HLA DSAs (hazard ratio, 2.07; 95% confidence interval, 1.03 to 4.17;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    =0.04). Moreover, patients with Nabs and DSAs had a further increased risk of kidney graft loss.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    These findings reveal an association between Nabs, kidney graft injury, and eventual graft failure, suggesting the involvement of Nabs in immune mechanisms of rejection.\n                  <\/jats:p>","DOI":"10.1681\/asn.2017111157","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T10:15:15Z","timestamp":1522404915000},"page":"1761-1770","source":"Crossref","is-referenced-by-count":40,"title":["Post-Transplant Natural Antibodies Associate with Kidney Allograft Injury and Reduced Long-Term Survival"],"prefix":"10.1681","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-317X","authenticated-orcid":false,"given":"Sarah B.","family":"See","sequence":"first","affiliation":[{"name":"Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Aubert","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation, Hopital Necker, Universit\u00e9 Paris Descartes and Assistance Publique Hopitaux de Paris, Paris, France;"},{"name":"Paris Translational Research Center for Organ Transplantation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche S970, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-7747","authenticated-orcid":false,"given":"Alexandre","family":"Loupy","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation, Hopital Necker, Universit\u00e9 Paris Descartes and Assistance Publique Hopitaux de Paris, Paris, France;"},{"name":"Paris Translational Research Center for Organ Transplantation, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche S970, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yokarla","family":"Veras","sequence":"additional","affiliation":[{"name":"Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Lebreton","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation, Hopital Necker, Universit\u00e9 Paris Descartes and Assistance Publique Hopitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology\/Transplant Center, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Legendre","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation, Hopital Necker, Universit\u00e9 Paris Descartes and Assistance Publique Hopitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Anglicheau","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation, Hopital Necker, Universit\u00e9 Paris Descartes and Assistance Publique Hopitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Zorn","sequence":"additional","affiliation":[{"name":"Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, New 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