{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:24:04Z","timestamp":1792268644482,"version":"4.4.0"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26293202"],"award-info":[{"award-number":["26293202"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02822"],"award-info":[{"award-number":["18H02822"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008695","name":"Japan Foundation for Applied Enzymology","doi-asserted-by":"publisher","award":["JP19gm0910013"],"award-info":[{"award-number":["JP19gm0910013"]}],"id":[{"id":"10.13039\/100008695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      Ferroptosis, cell death mediated by free radical reactions and driven by oxidative degradation of lipids, is a therapeutic target because of its role in organ injuries, including AKI. However, the ferroptosis-causing radicals targeted by ferroptosis suppressors have not been unequivocally identified. Certain cytochrome P450 substrate drugs are known to prevent lipid peroxidation\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      obscure mechanisms. The authors screened cytochrome P450 substrate drugs, identifying a diverse group of drugs with antiferroptotic properties, including promethazine and rifampicin. The antiferroptotic effect of these drugs was linked to their scavenging activity against lipid peroxyl radicals. Elevated lipid peroxyl radical levels were associated with ferroptosis onset, whereas radical scavenging by the drugs suppressed ferroptosis-related pathologic changes in different renal cell types and ameliorated organ injuries (including AKI) in mice, suggesting therapeutic potential for such repurposed drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Ferroptosis, nonapoptotic cell death mediated by free radical reactions and driven by the oxidative degradation of lipids, is a therapeutic target because of its role in organ damage, including AKI. Ferroptosis-causing radicals that are targeted by ferroptosis suppressors have not been unequivocally identified. Because certain cytochrome P450 substrate drugs can prevent lipid peroxidation\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      obscure mechanisms, we evaluated their antiferroptotic potential and used them to identify ferroptosis-causing radicals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a cell-based assay, we screened cytochrome P450 substrate compounds to identify drugs with antiferroptotic activity and investigated the underlying mechanism. To evaluate radical-scavenging activity, we used electron paramagnetic resonance\u2013spin trapping methods and a fluorescence probe for lipid radicals, NBD-Pen, that we had developed. We then assessed the therapeutic potency of these drugs in mouse models of cisplatin-induced AKI and LPS\/galactosamine-induced liver injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified various US Food and Drug Administration\u2013approved drugs and hormones that have antiferroptotic properties, including rifampicin, promethazine, omeprazole, indole-3-carbinol, carvedilol, propranolol, estradiol, and thyroid hormones. The antiferroptotic drug effects were closely associated with the scavenging of lipid peroxyl radicals but not significantly related to interactions with other radicals. The elevated lipid peroxyl radical levels were associated with ferroptosis onset, and known ferroptosis suppressors, such as ferrostatin-1, also functioned as lipid peroxyl radical scavengers. The drugs exerted antiferroptotic activities in various cell types, including tubules, podocytes, and renal fibroblasts. Moreover, in mice, the drugs ameliorated AKI and liver injury, with suppression of tissue lipid peroxidation and decreased cell death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although elevated lipid peroxyl radical levels can trigger ferroptosis onset, some drugs that scavenge lipid peroxyl radicals can help control ferroptosis-related disorders, including AKI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2019060570","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T14:25:14Z","timestamp":1574691914000},"page":"280-296","source":"Crossref","is-referenced-by-count":164,"title":["Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers"],"prefix":"10.1681","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-2745","authenticated-orcid":false,"given":"Eikan","family":"Mishima","sequence":"first","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"},{"name":"Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Ito","sequence":"additional","affiliation":[{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitose","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Toyohara","sequence":"additional","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadayoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"},{"name":"Katta Public General Hospital, Shiroishi, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-4660","authenticated-orcid":false,"given":"Takaaki","family":"Abe","sequence":"additional","affiliation":[{"name":"Nephrology, Endocrinology, and Vascular Medicine and"},{"name":"Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, Sendai, Japan;"},{"name":"Department of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"B1-20230829","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death.","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B2-20230829","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4.","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B3-20230829","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease.","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B5-20230829","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy.","volume":"116","author":"Fang","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B6-20230829","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1172\/JCI126428","article-title":"Ferroptotic cell death and TLR4\/Trif signaling initiate neutrophil recruitment after heart transplantation.","volume":"129","author":"Li","year":"2019","journal-title":"J Clin Invest"},{"key":"B7-20230829","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1073\/pnas.1415518111","article-title":"Synchronized renal tubular cell death involves ferroptosis.","volume":"111","author":"Linkermann","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B8-20230829","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat Cell Biol"},{"key":"B9-20230829","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2015121376","article-title":"Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI.","volume":"28","author":"Martin-Sanchez","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B10-20230829","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1681\/ASN.2018010039","article-title":"Lipid peroxidation drives renal cyst growth in vitro through activation of TMEM16A.","volume":"30","author":"Schreiber","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"B11-20230829","doi-asserted-by":"crossref","first-page":"8961","DOI":"10.1096\/fj.201900077R","article-title":"Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death.","volume":"33","author":"Guerrero-Hue","year":"2019","journal-title":"FASEB J"},{"key":"B12-20230829","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2005.08.072","article-title":"Lipid peroxidation: Mechanisms, inhibition, and biological effects.","volume":"338","author":"Niki","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"B13-20230829","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2016.03.052","article-title":"Identification of baicalein as a ferroptosis inhibitor by natural product library screening.","volume":"473","author":"Xie","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B14-20230829","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acscentsci.7b00028","article-title":"On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.","volume":"3","author":"Zilka","year":"2017","journal-title":"ACS Cent Sci"},{"key":"B15-20230829","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat Chem Biol"},{"key":"B16-20230829","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1089\/ars.2005.7.170","article-title":"New insights regarding the autoxidation of polyunsaturated fatty acids.","volume":"7","author":"Yin","year":"2005","journal-title":"Antioxid Redox Signal"},{"key":"B17-20230829","doi-asserted-by":"crossref","first-page":"e2006203","DOI":"10.1371\/journal.pbio.2006203","article-title":"Unsolved mysteries: How does lipid peroxidation cause ferroptosis?","volume":"16","author":"Feng","year":"2018","journal-title":"PLoS Biol"},{"key":"B18-20230829","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.","volume":"136","author":"Skouta","year":"2014","journal-title":"J Am Chem Soc"},{"key":"B19-20230829","doi-asserted-by":"crossref","first-page":"20968","DOI":"10.1016\/S0021-9258(19)30031-6","article-title":"Lipid peroxyl radical intermediates in the peroxidation of polyunsaturated fatty acids by lipoxygenase. Direct electron spin resonance investigations.","volume":"264","author":"Chamulitrat","year":"1989","journal-title":"J Biol Chem"},{"key":"B20-20230829","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nchembio.2105","article-title":"Fluorescence probes to detect lipid-derived radicals.","volume":"12","author":"Yamada","year":"2016","journal-title":"Nat Chem Biol"},{"key":"B21-20230829","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","article-title":"Clinical importance of the cytochromes P450.","volume":"360","author":"Nebert","year":"2002","journal-title":"Lancet"},{"key":"B22-20230829","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0891-5849(97)00463-2","article-title":"Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes.","volume":"24","author":"Puntarulo","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"B23-20230829","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-5793(83)80065-9","article-title":"Cytochrome P450 oxidase activity and its role in NADPH dependent lipid peroxidation.","volume":"151","author":"Bast","year":"1983","journal-title":"FEBS Lett"},{"key":"B24-20230829","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/bj1130333","article-title":"Lipid peroxide formation in microsomes. Relationship of hydroxylation to lipid peroxide formation.","volume":"113","author":"Wills","year":"1969","journal-title":"Biochem J"},{"key":"B25-20230829","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1254\/jjp.69.325","article-title":"Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice.","volume":"69","author":"Huang","year":"1995","journal-title":"Jpn J Pharmacol"},{"key":"B26-20230829","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11255-017-1775-8","article-title":"An evaluation of the protective effect of esomeprazole in an experimental model of renal ischemia-reperfusion.","volume":"50","author":"Ozkan","year":"2018","journal-title":"Int Urol Nephrol"},{"key":"B27-20230829","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2015.03.056","article-title":"The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis.","volume":"297","author":"Liechti","year":"2015","journal-title":"Neuroscience"},{"key":"B28-20230829","doi-asserted-by":"crossref","first-page":"F557","DOI":"10.1152\/ajprenal.00509.2009","article-title":"Conditionally immortalized human podocyte cell lines established from urine.","volume":"298","author":"Sakairi","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"B29-20230829","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/10715769800300421","article-title":"Carvedilol inhibition of lipid peroxidation. A new antioxidative mechanism.","volume":"29","author":"Tadolini","year":"1998","journal-title":"Free Radic Res"},{"key":"B30-20230829","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1271\/bbb.60593","article-title":"Antioxidant properties of aqueous extracts from red tide plankton cultures.","volume":"71","author":"Niwano","year":"2007","journal-title":"Biosci Biotechnol Biochem"},{"key":"B31-20230829","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/jb\/mvr051","article-title":"Kinetic analysis of reactive oxygen species generated by the in vitro reconstituted NADPH oxidase and xanthine oxidase systems.","volume":"150","author":"Sato","year":"2011","journal-title":"J Biochem"},{"key":"B32-20230829","doi-asserted-by":"crossref","first-page":"431","DOI":"10.5650\/jos.ess13225","article-title":"Preparation of 13 or 9-hydroperoxy-9Z,11E (9E,11E) or 10E,12Z (10E,12E)-octadecadienoic phosphatidylcholine hydroperoxide.","volume":"63","author":"Kato","year":"2014","journal-title":"J Oleo Sci"},{"key":"B33-20230829","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.bbrc.2015.02.063","article-title":"Metabolism and cytotoxic effects of phosphatidylcholine hydroperoxide in human hepatoma HepG2 cells.","volume":"458","author":"Suzuki","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"B34-20230829","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1681\/ASN.2013091001","article-title":"Conformational change in transfer RNA is an early indicator of acute cellular damage.","volume":"25","author":"Mishima","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"B35-20230829","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/s41598-017-01702-7","article-title":"A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-\u03b1 and TGF-\u03b2 1 pathways.","volume":"7","author":"Shima","year":"2017","journal-title":"Sci Rep"},{"key":"B36-20230829","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1681\/ASN.2014060530","article-title":"Alteration of the intestinal environment by lubiprostone is associated with amelioration of adenine-induced CKD.","volume":"26","author":"Mishima","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B38-20230829","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2018.03.113","article-title":"ENPP2 protects cardiomyocytes from erastin-induced ferroptosis.","volume":"499","author":"Bai","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B39-20230829","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and function.","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"},{"key":"B40-20230829","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation.","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat Chem Biol"},{"key":"B41-20230829","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ab.2014.10.017","article-title":"Liquid chromatography-tandem mass spectrometry determination of human plasma 1-palmitoyl-2-hydroperoxyoctadecadienoyl-phosphatidylcholine isomers via promotion of sodium adduct formation.","volume":"471","author":"Kato","year":"2015","journal-title":"Anal Biochem"},{"key":"B42-20230829","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis.","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B43-20230829","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1089\/ars.2016.6874","article-title":"Methionine sulfoxide reductase a deficiency exacerbates cisplatin-induced nephrotoxicity via increased mitochondrial damage and renal cell death.","volume":"27","author":"Noh","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"B44-20230829","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S1359-6446(04)03115-0","article-title":"Compound lipophilicity for substrate binding to human P450s in drug metabolism.","volume":"9","author":"Lewis","year":"2004","journal-title":"Drug Discov Today"},{"key":"B45-20230829","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-2952(88)90737-X","article-title":"Intervention in free radical mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol.","volume":"37","author":"Shertzer","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"B47-20230829","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0006-2952(99)00417-7","article-title":"Antioxidant action of the antihypertensive drug, carvedilol, against lipid peroxidation.","volume":"59","author":"Noguchi","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"B48-20230829","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF02536137","article-title":"The effect of beta blocking drugs on lipid peroxidation in rat heart in vitro.","volume":"27","author":"Jenkins","year":"1992","journal-title":"Lipids"},{"key":"B49-20230829","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0039-128X(96)00044-X","article-title":"Inhibition of lipid peroxidation by estradiol and 2-hydroxyestradiol.","volume":"61","author":"Miura","year":"1996","journal-title":"Steroids"},{"key":"B51-20230829","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbrc.2016.05.030","article-title":"3,3\u2032,5-triiodothyroxine inhibits apoptosis and oxidative stress by the PKM2\/PKM1 ratio during oxygen-glucose deprivation\/reperfusion AC16 and HCM-a cells: T3 inhibits apoptosis and oxidative stress by PKM2\/PKM1 ratio.","volume":"475","author":"Li","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B52-20230829","doi-asserted-by":"crossref","first-page":"13092","DOI":"10.1074\/jbc.M601984200","article-title":"17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione\/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells.","volume":"281","author":"Urata","year":"2006","journal-title":"J Biol Chem"},{"key":"B53-20230829","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1254\/jjp.57.259","article-title":"The iron chelator deferoxamine prevents cisplatin-induced lipid peroxidation in rat kidney cortical slices.","volume":"57","author":"Kameyama","year":"1991","journal-title":"Jpn J Pharmacol"},{"key":"B54-20230829","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/jphp.12990","article-title":"Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats.","volume":"70","author":"Makhdoumi","year":"2018","journal-title":"J Pharm Pharmacol"},{"key":"B55-20230829","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1021\/acs.jmedchem.5b01641","article-title":"Novel ferroptosis inhibitors with improved potency and ADME properties.","volume":"59","author":"Hofmans","year":"2016","journal-title":"J Med Chem"},{"key":"B56-20230829","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.2042-7158.1983.tb02935.x","article-title":"Determinants of systemic availability of promethazine in rabbits.","volume":"35","author":"Taylor","year":"1983","journal-title":"J Pharm Pharmacol"},{"key":"B57-20230829","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/cpt.778","article-title":"A population pharmacokinetic model incorporating saturable pharmacokinetics and autoinduction for high rifampicin doses.","volume":"103","author":"Svensson","year":"2018","journal-title":"Clin Pharmacol Ther"},{"key":"B58-20230829","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41419-018-0670-2","article-title":"Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway.","volume":"9","author":"Zhou","year":"2018","journal-title":"Cell Death Dis"},{"key":"B59-20230829","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"B60-20230829","first-page":"6417","article-title":"Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.","volume":"34","author":"Lachaier","year":"2014","journal-title":"Anticancer Res"},{"key":"B61-20230829","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4143\/crt.2016.572","article-title":"Ferroptosis: A novel anti-tumor action for cisplatin.","volume":"50","author":"Guo","year":"2018","journal-title":"Cancer Res Treat"},{"key":"B62-20230829","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.freeradbiomed.2017.04.024","article-title":"Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis.","volume":"108","author":"Toyokuni","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"B63-20230829","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.kint.2015.10.008","article-title":"Nonapoptotic cell death in acute kidney injury and transplantation.","volume":"89","author":"Linkermann","year":"2016","journal-title":"Kidney Int"},{"key":"B64-20230829","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1053\/j.gastro.2017.05.046","article-title":"Association between proton pump inhibitor use and risk of progression of chronic kidney disease.","volume":"153","author":"Klatte","year":"2017","journal-title":"Gastroenterology"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2019060570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:22:18Z","timestamp":1786130538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2019060570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2019060570","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]}}}