{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:01:40Z","timestamp":1792555300343,"version":"4.5.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes, Digestive, and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK-118431"],"award-info":[{"award-number":["R01-DK-118431"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes, Digestive, and Kidney Diseases","doi-asserted-by":"publisher","award":["U54-DK-083912"],"award-info":[{"award-number":["U54-DK-083912"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NephCure Kidney International"},{"name":"Halpin Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Glomerular features ascertained by electron microscopy are underreported in clinical practice, and their value in predicting outcome is unclear. This study is the first comprehensive investigation of the association of clinical outcomes with 12 glomerular electron microscopy descriptors reflecting the status of podocytes, endothelial cells, and glomerular basement membranes, individually and as electron microscopy profiles after descriptor-based consensus clustering. The authors demonstrate that severe effacement and microvillous transformation, individually and as a component of clusters, were associated with proteinuria remission, whereas prominent endothelial cell and glomerular basement membrane abnormalities were associated with loss of renal function. These findings highlight the importance of a standardized and comprehensive ultrastructural analysis, and that use of quantifiable structural changes in assessing patients with proteinuria might have important clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The analysis and reporting of glomerular features ascertained by electron microscopy are limited to few parameters with minimal predictive value, despite some contributions to disease diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We investigated the prognostic value of 12 electron microscopy histologic and ultrastructural changes (descriptors) from the Nephrotic Syndrome Study Network (NEPTUNE) Digital Pathology Scoring System. Study pathologists scored 12 descriptors in NEPTUNE renal biopsies from 242 patients with minimal change disease or FSGS, with duplicate readings to evaluate reproducibility. We performed consensus clustering of patients to identify unique electron microscopy profiles. For both individual descriptors and clusters, we used Cox regression models to assess associations with time from biopsy to proteinuria remission and time to a composite progression outcome (\u226540% decline in eGFR, with eGFR&lt;60 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      , or ESKD), and linear mixed models for longitudinal eGFR measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intrarater and interrater reproducibility was &gt;0.60 for 12 out of 12 and seven out of 12 descriptors, respectively. Individual podocyte descriptors such as effacement and microvillous transformation were associated with complete remission, whereas endothelial cell and glomerular basement membrane abnormalities were associated with progression. We identified six descriptor-based clusters with distinct electron microscopy profiles and clinical outcomes. Patients in a cluster with more prominent foot process effacement and microvillous transformation had the highest rates of complete proteinuria remission, whereas patients in clusters with extensive loss of primary processes and endothelial cell damage had the highest rates of the composite progression outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systematic analysis of electron microscopic findings reveals clusters of findings associated with either proteinuria remission or disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2019080825","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T15:25:20Z","timestamp":1582298720000},"page":"841-854","source":"Crossref","is-referenced-by-count":44,"title":["Ultrastructural Characterization of Proteinuric Patients Predicts Clinical Outcomes"],"prefix":"10.1681","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-8423","authenticated-orcid":false,"given":"Virginie","family":"Royal","sequence":"first","affiliation":[{"name":"Department of Pathology, H\u00f4pital Maisonneuve-Rosemont, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarcy","family":"Zee","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Avila-Casado","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of Toronto, Scarborough, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura H.","family":"Mariani","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Holzman","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-0612","authenticated-orcid":false,"given":"Brenda W.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Hodgin","sequence":"additional","affiliation":[{"name":"Renal Pathology, Department of Pathology, University of Michigan, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barisoni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"B1-20231107","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/ki.1994.388","article-title":"The many masks of focal segmental glomerulosclerosis","volume":"46","author":"D\u2019Agati","year":"1994","journal-title":"Kidney Int"},{"key":"B2-20231107","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1046\/j.1523-1755.2001.0590041498.x","article-title":"Obesity-related glomerulopathy: An emerging epidemic","volume":"59","author":"Kambham","year":"2001","journal-title":"Kidney Int"},{"key":"B3-20231107","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/ki.2008.413","article-title":"Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis","volume":"74","author":"Deegens","year":"2008","journal-title":"Kidney Int"},{"key":"B4-20231107","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.mayocp.2017.09.011","article-title":"The incidence of primary vs secondary focal segmental glomerulosclerosis: A clinicopathologic study","volume":"92","author":"Hommos","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"B5-20231107","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/ckj\/sfu100","article-title":"Focal and segmental glomerulosclerosis: Clinical and kidney biopsy correlations","volume":"7","author":"Sethi","year":"2014","journal-title":"Clin Kidney J"},{"key":"B6-20231107","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/ckj\/sfw129","article-title":"Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology","volume":"10","author":"Barisoni","year":"2017","journal-title":"Clin Kidney J"},{"key":"B7-20231107","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2215\/CJN.08370812","article-title":"Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE)","volume":"8","author":"Barisoni","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"B8-20231107","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/ki.2012.428","article-title":"Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach","volume":"83","author":"Gadegbeku","year":"2013","journal-title":"Kidney Int"},{"key":"B9-20231107","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ki.2009.168","article-title":"The Oxford classification of IgA nephropathy: Pathology definitions, correlations, and reproducibility","volume":"76","author":"Roberts","year":"2009","journal-title":"Kidney Int"},{"key":"B10-20231107","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1093\/ndt\/gfy337","article-title":"Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: Evidence from the validation of IGA study cohort","volume":"34","author":"Bellur","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"B11-20231107","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1177\/0961203317706556","article-title":"Systematic review of the literature on reproducibility of the interpretation of renal biopsy in lupus nephritis","volume":"26","author":"Restrepo-Escobar","year":"2017","journal-title":"Lupus"},{"key":"B12-20231107","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/modpathol.2016.58","article-title":"Reproducibility of the NEPTUNE descriptor-based scoring system on whole-slide images and histologic and ultrastructural digital images","volume":"29","author":"Barisoni","year":"2016","journal-title":"Mod Pathol"},{"key":"B13-20231107","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.semnephrol.2015.04.006","article-title":"Morphology in the digital age: Integrating high-resolution description of structural alterations with phenotypes and genotypes","volume":"35","author":"Nast","year":"2015","journal-title":"Semin Nephrol"},{"key":"B14-20231107","doi-asserted-by":"crossref","first-page":"613","DOI":"10.5858\/arpa.2017-0181-OA","article-title":"Reproducibility and feasibility of strategies for morphologic assessment of renal biopsies using the Nephrotic Syndrome Study Network digital pathology scoring system","volume":"142","author":"Zee","year":"2018","journal-title":"Arch Pathol Lab Med"},{"key":"B15-20231107","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1023949509487","article-title":"Consensus clustering: A resampling-based method for class discovery and visualization of gene expression microarray data","volume":"52","author":"Monti","year":"2003","journal-title":"Mach Learn"},{"key":"B16-20231107","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1038\/srep06207","article-title":"Critical limitations of consensus clustering in class discovery","volume":"4","author":"\u0218enbabao\u011flu","year":"2014","journal-title":"Sci Rep"},{"key":"B17-20231107","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/modpathol.3800239","article-title":"Practice guidelines for the renal biopsy","volume":"17","author":"Walker","year":"2004","journal-title":"Mod Pathol"},{"key":"B18-20231107","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1681\/ASN.V10151","article-title":"The dysregulated podocyte phenotype: A novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy","volume":"10","author":"Barisoni","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"B19-20231107","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ki.1975.16","article-title":"Focal glomerular sclerosis in nephrotic patients: An electron microscopic study of glomerular podocytes","volume":"7","author":"Grishman","year":"1975","journal-title":"Kidney Int"},{"key":"B20-20231107","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ki.1985.225","article-title":"Focal segmental glomerular sclerosis: The cellular lesion","volume":"28","author":"Schwartz","year":"1985","journal-title":"Kidney Int"},{"key":"B21-20231107","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00005792-197601000-00004","article-title":"Focal glomerular sclerosis: Contrasting clinical patterns in children and adults","volume":"55","author":"Newman","year":"1976","journal-title":"Medicine (Baltimore)"},{"key":"B22-20231107","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/j.1523-1755.2004.00964.x","article-title":"Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies","volume":"66","author":"van den Berg","year":"2004","journal-title":"Kidney Int"},{"key":"B23-20231107","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00428-015-1821-9","article-title":"Podocyte and endothelial injury in focal segmental glomerulosclerosis: An ultrastructural analysis","volume":"467","author":"Taneda","year":"2015","journal-title":"Virchows Arch"},{"key":"B24-20231107","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41581-018-0098-z","article-title":"Endothelium structure and function in kidney health and disease","volume":"15","author":"Jourde-Chiche","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"B25-20231107","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MNH.0b013e3283522e7a","article-title":"The glomerular endothelium: New insights on function and structure","volume":"21","author":"Haraldsson","year":"2012","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B26-20231107","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000101796","article-title":"Contribution of the endothelium to the glomerular permselectivity barrier in health and disease","volume":"106","author":"Ballermann","year":"2007","journal-title":"Nephron, Physiol"},{"key":"B27-20231107","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrneph.2010.152","article-title":"Endothelial dysfunction as a potential contributor in diabetic nephropathy","volume":"7","author":"Nakagawa","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"B28-20231107","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000491663","article-title":"Expression of endothelial cell injury marker Cd146 correlates with disease severity and predicts the renal outcomes in patients with diabetic nephropathy","volume":"48","author":"Fan","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B29-20231107","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00592-018-1211-2","article-title":"Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy","volume":"55","author":"Maestroni","year":"2018","journal-title":"Acta Diabetol"},{"key":"B30-20231107","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.2337\/db07-0019","article-title":"Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy","volume":"56","author":"Toyoda","year":"2007","journal-title":"Diabetes"},{"key":"B31-20231107","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/ki.2012.234","article-title":"Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy","volume":"82","author":"Weil","year":"2012","journal-title":"Kidney Int"},{"key":"B32-20231107","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev-physiol-021115-105412","article-title":"Vascular growth factors and glomerular disease","volume":"78","author":"Bartlett","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"B33-20231107","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"B34-20231107","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","article-title":"Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria","volume":"278","author":"Sugimoto","year":"2003","journal-title":"J Biol Chem"},{"key":"B35-20231107","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002175","article-title":"Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1","volume":"71","author":"Makris","year":"2007","journal-title":"Kidney Int"},{"key":"B36-20231107","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0140-6736(92)91401-S","article-title":"Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus","volume":"340","author":"Stehouwer","year":"1992","journal-title":"Lancet"},{"key":"B37-20231107","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2337\/diab.40.8.971","article-title":"Von Willebrand factor and development of diabetic nephropathy in IDDM","volume":"40","author":"Stehouwer","year":"1991","journal-title":"Diabetes"},{"key":"B38-20231107","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1007\/s001250050619","article-title":"Macro-microangiopathy and endothelial dysfunction in NIDDM patients with and without diabetic nephropathy","volume":"39","author":"Parving","year":"1996","journal-title":"Diabetologia"},{"key":"B39-20231107","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.biocel.2010.05.015","article-title":"The glomerulus--a view from the inside--the endothelial cell","volume":"42","author":"Fogo","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"B40-20231107","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/his.13454","article-title":"Podocyte and endothelial cell injury lead to nephrotic syndrome in proliferative lupus nephritis","volume":"72","author":"Nawata","year":"2018","journal-title":"Histopathology"},{"key":"B41-20231107","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000020540","article-title":"Apoptosis in glomerular endothelial cells during the development of glomerulosclerosis in the remnant-kidney model","volume":"6","author":"Kitamura","year":"1998","journal-title":"Exp Nephrol"},{"key":"B42-20231107","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1440-1797.2012.01575.x","article-title":"Biomarkers of endothelial dysfunction in patients with primary focal segmental glomerulosclerosis","volume":"17","author":"Zhang","year":"2012","journal-title":"Nephrology (Carlton)"},{"key":"B43-20231107","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1172\/JCI71195","article-title":"Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis","volume":"124","author":"Daehn","year":"2014","journal-title":"J Clin Invest"},{"key":"B44-20231107","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1681\/ASN.2007080926","article-title":"Current views on collapsing glomerulopathy","volume":"19","author":"Albaqumi","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B45-20231107","first-page":"S64","article-title":"The role of podocytes in the development of glomerular sclerosis","volume":"45","author":"Kriz","year":"1994","journal-title":"Kidney Int Suppl"},{"key":"B46-20231107","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/MNH.0b013e3280c8eed3","article-title":"New insights into structural patterns encountered in glomerulosclerosis","volume":"16","author":"LeHir","year":"2007","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B47-20231107","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1681\/ASN.2005010055","article-title":"Podocyte depletion causes glomerulosclerosis: Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene","volume":"16","author":"Wharram","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"B48-20231107","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1681\/ASN.2012070739","article-title":"Renal lesions predict progression of diabetic nephropathy in type 1 diabetes","volume":"24","author":"Caramori","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B49-20231107","doi-asserted-by":"crossref","first-page":"F831","DOI":"10.1152\/ajprenal.00313.2016","article-title":"Rethinking glomerular basement membrane thickening in diabetic nephropathy: Adaptive or pathogenic?","volume":"311","author":"Marshall","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"B50-20231107","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.2174\/138161207781662957","article-title":"The podocyte: A potential therapeutic target in diabetic nephropathy?","volume":"13","author":"Marshall","year":"2007","journal-title":"Curr Pharm Des"},{"key":"B51-20231107","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2017090958","article-title":"Differentiating primary, genetic, and secondary FSGS in adults: A clinicopathologic approach","volume":"29","author":"De Vriese","year":"2018","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2019080825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:30:15Z","timestamp":1786131015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2019080825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2019080825","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]}}}