{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:05:00Z","timestamp":1792267500651,"version":"4.4.0"},"reference-count":91,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK108408"],"award-info":[{"award-number":["R01DK108408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK108859"],"award-info":[{"award-number":["R01DK108859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Understanding fructose metabolism might provide insights to renal pathophysiology. To support systemic glucose concentration, the proximal tubular cells reabsorb fructose as a substrate for gluconeogenesis. However, in instances when fructose intake is excessive, fructose metabolism is costly, resulting in energy depletion, uric acid generation, inflammation, and fibrosis in the kidney. A recent scientific advance is the discovery that fructose can be endogenously produced from glucose under pathologic conditions, not only in kidney diseases, but also in diabetes, in cardiac hypertrophy, and with dehydration. Why humans have such a deleterious mechanism to produce fructose is unknown, but it may relate to an evolutionary benefit in the past. In this article, we aim to illuminate the roles of fructose as it relates to gluconeogenesis and fructoneogenesis in the kidney.<\/jats:p>","DOI":"10.1681\/asn.2019101015","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T17:14:41Z","timestamp":1586193281000},"page":"898-906","source":"Crossref","is-referenced-by-count":93,"title":["Fructose Production and Metabolism in the Kidney"],"prefix":"10.1681","volume":"31","author":[{"given":"Takahiko","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Nephrology, Rakuwakai Otowa Hospital, Kyoto, Japan"},{"name":"Department of Biochemistry, Shiga University of Medical Science, Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Andres-Hernando","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Roncal-Jimenez","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-9617","authenticated-orcid":false,"given":"Laura G.","family":"Sanchez-Lozada","sequence":"additional","affiliation":[{"name":"Department of Cardio-Renal Physiopathology, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean R.","family":"Tolan","sequence":"additional","affiliation":[{"name":"Department of Biology, Boston University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-1831","authenticated-orcid":false,"given":"Miguel A.","family":"Lanaspa","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"B1-20230829","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/joim.12993","article-title":"Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts","volume":"287","author":"Johnson","year":"2020","journal-title":"J Intern Med"},{"key":"B2-20230829","first-page":"315","article-title":"Temporary fat storage, an adaptation of some fish species to the water level fluctuations and related environmental changes of the Amazon river","volume":"9","author":"Junk","year":"1985","journal-title":"Amazoniana"},{"key":"B3-20230829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00114-001-0279-6","article-title":"How to get fat: Nutritional mechanisms of seasonal fat accumulation in migratory songbirds","volume":"89","author":"Bairlein","year":"2002","journal-title":"Naturwissenschaften"},{"key":"B4-20230829","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ki.2012.396","article-title":"Hibernating bears (Ursidae): Metabolic magicians of definite interest for the nephrologist","volume":"83","author":"Stenvinkel","year":"2013","journal-title":"Kidney Int"},{"key":"B5-20230829","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/physrev.00008.2003","article-title":"Mammalian hibernation: Cellular and molecular responses to depressed metabolism and low temperature","volume":"83","author":"Carey","year":"2003","journal-title":"Physiol Rev"},{"key":"B6-20230829","first-page":"295","article-title":"Theodore E. 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