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Through modulating immune responses and\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progression and maintenance of kidney disease. In this Review, we provide an overview of the development, structure, and function of lymphatic vessels in the healthy adult kidney. We then highlight the contributions of lymphatic vessels to multiple forms of renal pathology, emphasizing CKD, transplant rejection, and polycystic kidney disease and discuss strategies to target renal lymphatics using genetic and pharmacologic approaches. Overall, we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and treatments modulating these vessels having therapeutic potential across the spectrum of kidney disease.\n                  <\/jats:p>","DOI":"10.1681\/asn.2019121320","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T17:35:16Z","timestamp":1586972116000},"page":"1178-1190","source":"Crossref","is-referenced-by-count":36,"title":["Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases"],"prefix":"10.1681","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-0394","authenticated-orcid":false,"given":"Daniyal J.","family":"Jafree","sequence":"first","affiliation":[{"name":"Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom"},{"name":"MB\/PhD Programme, Faculty of Medical Sciences, University College London, London, 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