{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:51:45Z","timestamp":1792191105461,"version":"4.4.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Although AKI is an important sequela of coronavirus disease 2019 (COVID-19), data on AKI treated with RRT (AKI-RRT) in patients with COVID-19 are limited. In a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to intensive care units (ICUs) at 67 hospitals across the United States, one in five patients developed AKI-RRT, 63% of whom died during hospitalization. Among patients who survived to hospital discharge, one in three remained RRT dependent at discharge, and one in six remained RRT dependent 60 days after ICU admission. The study identified several patient-and hospital-level risk factors for AKI-RRT and death. AKI-RRT is common among critically ill patients with COVID-19 and is associated with high mortality and persistent RRT dependence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>AKI is a common sequela of coronavirus disease 2019 (COVID-19). However, few studies have focused on AKI treated with RRT (AKI-RRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to intensive care units (ICUs) at 67 hospitals across the United States. We used multivariable logistic regression to identify patient-and hospital-level risk factors for AKI-RRT and to examine risk factors for 28-day mortality among such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 637 of 3099 patients (20.6%) developed AKI-RRT within 14 days of ICU admission, 350 of whom (54.9%) died within 28 days of ICU admission. Patient-level risk factors for AKI-RRT included CKD, men, non-White race, hypertension, diabetes mellitus, higher body mass index, higher\n                      <jats:sc>d<\/jats:sc>\n                      -dimer, and greater severity of hypoxemia on ICU admission. Predictors of 28-day mortality in patients with AKI-RRT were older age, severe oliguria, and admission to a hospital with fewer ICU beds or one with greater regional density of COVID-19. At the end of a median follow-up of 17 days (range, 1\u2013123 days), 403 of the 637 patients (63.3%) with AKI-RRT had died, 216 (33.9%) were discharged, and 18 (2.8%) remained hospitalized. Of the 216 patients discharged, 73 (33.8%) remained RRT dependent at discharge, and 39 (18.1%) remained RRT dependent 60 days after ICU admission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AKI-RRT is common among critically ill patients with COVID-19 and is associated with a hospital mortality rate of &gt;60%. Among those who survive to discharge, one in three still depends on RRT at discharge, and one in six remains RRT dependent 60 days after ICU admission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2020060897","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T19:12:39Z","timestamp":1602875559000},"page":"161-176","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":252,"title":["AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19"],"prefix":"10.1681","volume":"32","clinical-trial-number":[{"clinical-trial-number":"nct04343898","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-2151","authenticated-orcid":false,"given":"Shruti","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Renal Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-9168","authenticated-orcid":false,"given":"Steven G.","family":"Coca","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal L.","family":"Melamed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montefiore Medical Center\/Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hackensack Meridian School of Medicine, Seton Hall, Nutley, New Jersey"},{"name":"Department of Internal Medicine, Heart and Vascular Hospital, Hackensack Meridian Health Hackensack University Medical Center, Hackensack, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0180-349X","authenticated-orcid":false,"given":"Salim S.","family":"Hayek","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonika","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Leonberg-Yoo","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre M.","family":"Shehata","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hackensack Meridian Health Mountainside Medical Center, Glen Ridge, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Flythe","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina Kidney Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina"},{"name":"Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Schenck","sequence":"additional","affiliation":[{"name":"Divison of Pulmonary and Critical Care Medicine, Department of Medicine Weill Cornell Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitender","family":"Goyal","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Susan","family":"Hedayati","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajany","family":"Dy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University Medical Center, University of Nevada, Las Vegas, Nevada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anip","family":"Bansal","sequence":"additional","affiliation":[{"name":"Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambarish","family":"Athavale","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Cook County Health, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bryant","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Hyperbaric, Allergy, and Sleep Medicine, Loma Linda University Health, Loma Linda, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anitha","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Washington University, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-3583","authenticated-orcid":false,"given":"David M.","family":"Charytan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, New York University Grossman School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Schulze","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min J.","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allon N.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Anne","family":"Sosa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Judd","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos Q.","family":"Velez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ochsner Health System, New Orleans, Louisiana"},{"name":"Ochsner Clinical School, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Mallappallil","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Kings County Hospital Center, New York City Health and Hospital Corporation, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta E.","family":"Redfern","sequence":"additional","affiliation":[{"name":"Research Department, ProMedica Research, ProMedica Toledo Hospital, Toledo, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar D.","family":"Bansal","sequence":"additional","affiliation":[{"name":"Renal and Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Neyra","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Bone and Mineral Metabolism, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen D.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Critical Care Medicine, University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda D.","family":"Renaghan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Christov","sequence":"additional","affiliation":[{"name":"Department of Medicine-Nephrology, Westchester Medical Center, New York Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-330X","authenticated-orcid":false,"given":"Miklos Z.","family":"Molnar","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyak","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Kamal","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery Owusu","family":"Boateng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-4768","authenticated-orcid":false,"given":"Samuel A.P.","family":"Short","sequence":"additional","affiliation":[{"name":"University of Vermont Larner College of Medicine, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Admon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E.","family":"Sise","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Neurology, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-7385","authenticated-orcid":false,"given":"Chirag R.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Johns Hopkins School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7875-090X","authenticated-orcid":false,"given":"David E.","family":"Leaf","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the STOP-COVID Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"B1-20240826","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1161\/CIRCULATIONAHA.120.046941","article-title":"COVID-19 and cardiovascular disease","volume":"141","author":"Clerkin","year":"2020","journal-title":"Circulation"},{"key":"B2-20240826","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/jamacardio.2020.0950","article-title":"Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China","volume":"5","author":"Shi","year":"2020","journal-title":"JAMA Cardiol"},{"key":"B3-20240826","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"B4-20240826","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.kint.2020.03.005","article-title":"Kidney disease is associated with in-hospital death of patients with COVID-19","volume":"97","author":"Cheng","year":"2020","journal-title":"Kidney Int"},{"key":"B5-20240826","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.kint.2020.05.006","article-title":"Acute kidney injury in patients hospitalized with COVID-19","volume":"98","author":"Hirsch","year":"2020","journal-title":"Kidney Int"},{"key":"B6-20240826","doi-asserted-by":"crossref","first-page":"588","DOI":"10.34067\/KID.0003722020","article-title":"Acute kidney injury in the time of COVID-19","volume":"1","author":"Chan","year":"2020","journal-title":"Kidney360"},{"key":"B7-20240826","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.kint.2020.04.003","article-title":"Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China","volume":"98","author":"Su","year":"2020","journal-title":"Kidney Int"},{"key":"B8-20240826","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1681\/ASN.2020040419","article-title":"Acute kidney injury in COVID-19: Emerging evidence of a distinct pathophysiology","volume":"31","author":"Batlle","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"B9-20240826","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1681\/ASN.2020040432","article-title":"Ultrastructural evidence for direct renal infection with SARS-CoV-2","volume":"31","author":"Farkash","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"B10-20240826","doi-asserted-by":"crossref","first-page":"614","DOI":"10.34067\/KID.0002652020","article-title":"Acute kidney injury associated with coronavirus disease 2019 in urban New Orleans","volume":"1","author":"Mohamed","year":"2020","journal-title":"Kidney360"},{"issue":"9","key":"bib42-20240826","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1681\/ASN.2020040509","article-title":"AKI in Hospitalized Patients with COVID-19","volume":"31","author":"Chan","year":"2020","journal-title":"JASN"},{"key":"B11-20240826","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/01.CCM.0000045182.90302.B3","article-title":"Cost of acute renal failure requiring dialysis in the intensive care unit: Clinical and resource implications of renal recovery","volume":"31","author":"Manns","year":"2003","journal-title":"Crit Care Med"},{"key":"B12-20240826","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1097\/00003246-200209000-00016","article-title":"Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients","volume":"30","author":"Metnitz","year":"2002","journal-title":"Crit Care Med"},{"key":"B13-20240826","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1186\/cc12780","article-title":"Continuous renal replacement therapy outcomes in acute kidney injury and end-stage renal disease: A cohort study","volume":"17","author":"Allegretti","year":"2013","journal-title":"Crit Care"},{"key":"B14-20240826","article-title":"Factors associated with death among critically ill patients with coronavirus disease 2019 in the US [published online ahead of print July 15, 2020]","author":"Gupta","journal-title":"JAMA Intern Med"},{"key":"B15-20240826","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1053\/j.ajkd.2010.02.337","article-title":"Estimating GFR using the CKD epidemiology collaboration (CKD-EPI) creatinine equation: More accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions","volume":"55","author":"Levey","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"B16-20240826","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.2215\/CJN.12651214","article-title":"Kinetic eGFR and novel AKI biomarkers to predict renal recovery","volume":"10","author":"Dewitte","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"B17-20240826","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.kint.2016.04.008","article-title":"Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors","volume":"90","author":"Cortazar","year":"2016","journal-title":"Kidney Int"},{"key":"B18-20240826","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1681\/ASN.2020030276","article-title":"Renal involvement and early prognosis in patients with COVID-19 pneumonia","volume":"31","author":"Pei","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"B19-20240826","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","article-title":"Longitudinal data analysis using generalized linear models","volume":"73","author":"Liang","year":"1986","journal-title":"Biometrika"},{"key":"B20-20240826","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.kint.2019.01.020","article-title":"Tissue inhibitor metalloproteinase-2 (TIMP-2) \u2022 IGF-binding protein-7 (IGFBP7) levels are associated with adverse outcomes in patients in the intensive care unit with acute kidney injury","volume":"95","author":"Xie","year":"2019","journal-title":"Kidney Int"},{"key":"B21-20240826","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ki.2014.374","article-title":"Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac surgery","volume":"87","author":"Leaf","year":"2015","journal-title":"Kidney Int"},{"key":"B22-20240826","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bja.2018.08.010","article-title":"Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: Renal endpoints","volume":"121","author":"McIlroy","year":"2018","journal-title":"Br J Anaesth"},{"key":"B23-20240826","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/j.ajkd.2016.05.033","article-title":"End points for clinical trials in acute kidney injury","volume":"69","author":"Leaf","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"B24-20240826","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.2215\/CJN.02900311","article-title":"Model to predict mortality in critically ill adults with acute kidney injury","volume":"6","author":"Demirjian","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"B26-20240826","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1053\/j.ajkd.2010.01.011","article-title":"Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): Report from a Canadian province","volume":"55","author":"Sood","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"B27-20240826","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jcrc.2011.02.012","article-title":"Acute kidney injury in critically ill patients with pandemic influenza A pneumonia 2009 in Korea: A multicenter study","volume":"26","author":"Jung","year":"2011","journal-title":"J Crit Care"},{"key":"B28-20240826","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000328386","article-title":"2009 influenza A infection and acute kidney injury: Incidence, risk factors, and complications","volume":"34","author":"Demirjian","year":"2011","journal-title":"Am J Nephrol"},{"key":"B29-20240826","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/CCM.0000000000001398","article-title":"Obesity, acute kidney injury, and mortality in critical illness","volume":"44","author":"Danziger","year":"2016","journal-title":"Crit Care Med"},{"key":"B30-20240826","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/01.ASN.0000059863.48590.E9","article-title":"Acute renal failure in patients with sepsis in a surgical ICU: Predictive factors, incidence, comorbidity, and outcome","volume":"14","author":"Hoste","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"B31-20240826","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ki.2008.107","article-title":"The risk of acute renal failure in patients with chronic kidney disease","volume":"74","author":"Hsu","year":"2008","journal-title":"Kidney Int"},{"key":"B32-20240826","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1053\/j.ajkd.2008.03.005","article-title":"Recovery of kidney function after acute kidney injury in the elderly: A systematic review and meta-analysis","volume":"52","author":"Schmitt","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"B33-20240826","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1681\/ASN.2007080837","article-title":"Acute kidney injury increases risk of ESRD among elderly","volume":"20","author":"Ishani","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B34-20240826","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1097\/CCM.0000000000002878","article-title":"Hospital variation in renal replacement therapy for sepsis in the United States","volume":"46","author":"Valley","year":"2018","journal-title":"Crit Care Med"},{"key":"B35-20240826","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00134-019-05790-z","article-title":"ICU staffing feature phenotypes and their relationship with patients\u2019 outcomes: An unsupervised machine learning analysis","volume":"45","author":"Zampieri","year":"2019","journal-title":"Intensive Care Med"},{"key":"B36-20240826","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJMsa053993","article-title":"Hospital volume and the outcomes of mechanical ventilation","volume":"355","author":"Kahn","year":"2006","journal-title":"N Engl J Med"},{"key":"B37-20240826","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1378\/chest.14-2195","article-title":"The volume-outcome relationship in critical care: A systematic review and meta-analysis","volume":"148","author":"Nguyen","year":"2015","journal-title":"Chest"},{"key":"B38-20240826","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1399-6576.2012.02747.x","article-title":"Association of ICU size and annual case volume of renal replacement therapy patients with mortality","volume":"56","author":"Vaara","year":"2012","journal-title":"Acta Anaesthesiol Scand"},{"key":"B39-20240826","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jcrc.2018.08.024","article-title":"Hospital case volume and clinical outcomes in critically ill patients with acute kidney injury treated with dialysis","volume":"48","author":"Chimunda","year":"2018","journal-title":"J Crit Care"},{"key":"B40-20240826","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00134-007-0754-4","article-title":"Continuous renal replacement therapy: A worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators","volume":"33","author":"Uchino","year":"2007","journal-title":"Intensive Care Med"},{"key":"B41-20240826","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1164\/ajrccm.162.1.9907016","article-title":"A prospective, multicenter study of the epidemiology, management, and outcome of severe acute renal failure in a \u201cclosed\u201d ICU system","volume":"162","author":"Cole","year":"2000","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2020060897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:30:07Z","timestamp":1786131007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2020060897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2020060897","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738850649.793589302","asserted-by":"object"}]},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"assertion":[{"value":"2020-06-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}