{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:03:17Z","timestamp":1794243797277,"version":"4.9.0"},"reference-count":143,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI JP20K08585"],"award-info":[{"award-number":["KAKENHI JP20K08585"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI JP15H05788"],"award-info":[{"award-number":["KAKENHI JP15H05788"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Hypertension and its comorbidities pose a major public health problem associated with disease-associated factors related to a modern lifestyle, such high salt intake or obesity. Accumulating evidence has demonstrated that aldosterone and its receptor, the mineralocorticoid receptor (MR), have crucial roles in the development of salt-sensitive hypertension and coexisting cardiovascular and renal injuries. Accordingly, clinical trials have repetitively shown the promising effects of MR blockers in these diseases. We and other researchers have identified novel mechanisms of MR activation involved in salt-sensitive hypertension and renal injury, including the obesity-derived overproduction of aldosterone and ligand-independent signaling. Moreover, recent advances in the analysis of cell-specific and context-dependent mechanisms of MR activation in various tissues\u2014including a classic target of aldosterone, aldosterone-sensitive distal nephrons\u2014are now providing new insights. In this review, we summarize recent updates to our understanding of aldosterone-MR signaling, focusing on its role in salt-sensitive hypertension and renal injury.<\/jats:p>","DOI":"10.1681\/asn.2020071041","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T13:35:29Z","timestamp":1609767329000},"page":"279-289","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":41,"title":["The Mineralocorticoid Receptor in Salt-Sensitive Hypertension and Renal Injury"],"prefix":"10.1681","volume":"32","author":[{"given":"Nobuhiro","family":"Ayuzawa","sequence":"first","affiliation":[{"name":"Division of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-7060","authenticated-orcid":false,"given":"Toshiro","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan"},{"name":"Shinshu University School of Medicine, Nagano, Japan"},{"name":"Research Center for Social Systems, Shinshu University, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"B1-20240826","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","article-title":"Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor","volume":"237","author":"Arriza","year":"1987","journal-title":"Science"},{"key":"B2-20240826","doi-asserted-by":"crossref","first-page":"F1473","DOI":"10.1152\/ajprenal.00437.2010","article-title":"In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: Differential effect of corticosteroids along the distal tubule","volume":"299","author":"Ackermann","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"B3-20240826","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2215\/CJN.05760513","article-title":"Collecting duct principal cell transport processes and their regulation","volume":"10","author":"Pearce","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"B4-20240826","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.HYP.15.6.547","article-title":"Abnormal pressure natriuresis. 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