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Loss of podocytes due to injury could be mediated by the cleavage of podocyte cell-adhesion molecules through the action of the ectodomain sheddase A Disintegrin and Metalloproteinase 10 (ADAM10). ADAM10 is highly abundant at the site of blood filtration, the podocyte foot processes. Podocyte-expressed ADAM10 is not required for the development of the renal filter, but plays a major role in podocyte injury. After antibody-mediated injury, ADAM10 is upregulated in humans and mice. The protein cleaves cell-adhesion molecules at the slit diaphragm, leading to Wnt\/\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      -catenin signaling and podocyte loss. Therefore, ADAM10-mediated ectodomain shedding of injury-related cadherins drives podocyte injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Podocytes embrace the glomerular capillaries with foot processes, which are interconnected by a specialized adherens junction to ultimately form the filtration barrier. Altered adhesion and loss are common features of podocyte injury, which could be mediated by shedding of cell-adhesion molecules through the regulated activity of cell surface\u2013expressed proteases. A Disintegrin and Metalloproteinase 10 (ADAM10) is such a protease known to mediate ectodomain shedding of adhesion molecules, among others. Here we evaluate the involvement of ADAM10 in the process of antibody-induced podocyte injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Membrane proteomics, immunoblotting, high-resolution microscopy, and immunogold electron microscopy were used to analyze human and murine podocyte ADAM10 expression in health and kidney injury. The functionality of ADAM10 ectodomain shedding for podocyte development and injury was analyzed,\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      , in the anti-podocyte nephritis (APN) model in podocyte-specific, ADAM10-deficient mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ADAM10 is selectively localized at foot processes of murine podocytes and its expression is dispensable for podocyte development. Podocyte ADAM10 expression is induced in the setting of antibody-mediated injury in humans and mice. Podocyte ADAM10 deficiency attenuates the clinical course of APN and preserves the morphologic integrity of podocytes, despite subepithelial immune-deposit formation. Functionally, ADAM10-related ectodomain shedding results in cleavage of the cell-adhesion proteins N- and P-cadherin, thus decreasing their injury-related surface levels. This favors podocyte loss and the activation of downstream signaling events through the Wnt signaling pathway in an ADAM10-dependent manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ADAM10-mediated ectodomain shedding of injury-related cadherins drives podocyte injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2020081213","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T11:50:16Z","timestamp":1617105016000},"page":"1389-1408","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage"],"prefix":"10.1681","volume":"32","author":[{"given":"Marlies","family":"Sachs","sequence":"first","affiliation":[{"name":"Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Christian-Albrechts University Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Reichelt","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Sachs","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Schebsdat","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Zielinski","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Seipold","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Christian-Albrechts University Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-0470","authenticated-orcid":false,"given":"Lukas","family":"Heintz","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan A.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany"},{"name":"Neuroproteomics, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kretz","sequence":"additional","affiliation":[{"name":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Lindenmeyer","sequence":"additional","affiliation":[{"name":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4053-1474","authenticated-orcid":false,"given":"Thorsten","family":"Wiech","sequence":"additional","affiliation":[{"name":"Nephropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias B.","family":"Huber","sequence":"additional","affiliation":[{"name":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"L\u00fcllmann-Rauch","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Christian-Albrechts University Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan F.","family":"Lichtenthaler","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany"},{"name":"Neuroproteomics, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Saftig","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Christian-Albrechts University Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Meyer-Schwesinger","sequence":"additional","affiliation":[{"name":"Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"B1-20240826","doi-asserted-by":"crossref","first-page":"749010","DOI":"10.1155\/2012\/749010","article-title":"The glomerular filtration barrier: Components and crosstalk","volume":"2012","author":"Menon","year":"2012","journal-title":"Int J Nephrol"},{"key":"B2-20240826","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.V1111","article-title":"The glomerular slit diaphragm is a modified adherens junction","volume":"11","author":"Reiser","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"B3-20240826","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.ki.5000410","article-title":"The podocyte\u2019s response to injury: Role in proteinuria and glomerulosclerosis","volume":"69","author":"Shankland","year":"2006","journal-title":"Kidney Int"},{"key":"B4-20240826","first-page":"21","article-title":"3. 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