{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:01:36Z","timestamp":1786132896586,"version":"build-2736575974"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK118032"],"award-info":[{"award-number":["R01 DK118032"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK079328"],"award-info":[{"award-number":["P30DK079328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R33CA235254"],"award-info":[{"award-number":["R33CA235254"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM133522"],"award-info":[{"award-number":["R35GM133522"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention Research Institute of Texas","doi-asserted-by":"publisher","award":["RP150596"],"award-info":[{"award-number":["RP150596"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      Defects in renal lymphatics occur in various kidney diseases, but the role of the lymphatics in maintaining kidney structure and function is unknown. We combine tissue clearing, light-sheet microscopy, and computational analysis to characterize lymphatics and find that mice with a heterozygous mutation in\n                      <jats:italic toggle=\"yes\">Vegfr3<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">Vegfr3Chy\/+<\/jats:italic>\n                      ) have severely reduced renal lymphatics. Strikingly, these mice have indistinguishable renal function and histology compared with controls. Even after low-dose cisplatin injury, there are no differences in renal function, although\n                      <jats:italic toggle=\"yes\">Vegfr3Chy\/+<\/jats:italic>\n                      mice developed more perivascular inflammation. Our data present a novel method of lymphatic quantification and suggest that a normal complement of renal lymphatics is not essential for renal structure and function at baseline or after mild injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lymphatic abnormalities are observed in several types of kidney disease, but the relationship between the renal lymphatic system and renal function is unclear. The discovery of lymphatic-specific proteins, advances in microscopy, and available genetic mouse models provide the tools to help elucidate the role of renal lymphatics in physiology and disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We utilized a mouse model containing a missense mutation in\n                      <jats:italic toggle=\"yes\">Vegfr3<\/jats:italic>\n                      (dubbed\n                      <jats:italic toggle=\"yes\">Chy<\/jats:italic>\n                      ) that abrogates its kinase ability.\n                      <jats:italic toggle=\"yes\">Vegfr3Chy\/+<\/jats:italic>\n                      mice were examined for developmental abnormalities and kidney-specific outcomes. Control and\n                      <jats:italic toggle=\"yes\">Vegfr3Chy\/+<\/jats:italic>\n                      mice were subjected to cisplatin-mediated injury. We characterized renal lymphatics using tissue-clearing, light-sheet microscopy, and computational analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the kidney, VEGFR3 is expressed not only in lymphatic vessels but also, in various blood capillaries.\n                      <jats:italic toggle=\"yes\">Vegfr3Chy\/+<\/jats:italic>\n                      mice had severely reduced renal lymphatics with 100% penetrance, but we found no abnormalities in BP, serum creatinine, BUN, albuminuria, and histology. There was no difference in the degree of renal injury after low-dose cisplatin (5 mg\/kg), although\n                      <jats:italic toggle=\"yes\">Vegfr3Chy\/+<\/jats:italic>\n                      mice developed perivascular inflammation. Cisplatin-treated controls had no difference in total cortical lymphatic volume and length but showed increased lymphatic density due to decreased cortical volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrate that VEGFR3 is required for development of renal lymphatics. Our studies reveal that reduced lymphatic density does not impair renal function at baseline and induces only modest histologic changes after mild injury. We introduce a novel quantification method to evaluate renal lymphatics in 3D and demonstrate that accurate measurement of lymphatic density in CKD requires assessment of changes to cortical volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2021010061","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T14:46:00Z","timestamp":1632321960000},"page":"3099-3113","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":28,"title":["Heterozygous Mutation of Vegfr3 Reduces Renal Lymphatics without Renal Dysfunction"],"prefix":"10.1681","volume":"32","author":[{"given":"Hao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitkale","family":"Hiremath","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinten","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya","family":"Vora","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Shang","sequence":"additional","affiliation":[{"name":"Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-9379","authenticated-orcid":false,"given":"Andrew R.","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Fiolka","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-2320","authenticated-orcid":false,"given":"Kevin M.","family":"Dean","sequence":"additional","affiliation":[{"name":"Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Dellinger","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-4664","authenticated-orcid":false,"given":"Denise K.","family":"Marciano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"B1-20240826","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20171868","article-title":"Organ-specific lymphatic vasculature: From development to pathophysiology","volume":"215","author":"Petrova","year":"2018","journal-title":"J Exp Med"},{"key":"B2-20240826","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: Molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"B3-20240826","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature04480","article-title":"Lymphangiogenesis in development and human disease","volume":"438","author":"Alitalo","year":"2005","journal-title":"Nature"},{"key":"B4-20240826","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1681\/ASN.2019121320","article-title":"Beyond a passive conduit: Implications of lymphatic biology for kidney diseases","volume":"31","author":"Jafree","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"B5-20240826","doi-asserted-by":"crossref","first-page":"F861","DOI":"10.1152\/ajprenal.00679.2016","article-title":"Renal inflammation and injury are associated with lymphangiogenesis in hypertension","volume":"312","author":"Kneedler","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"B6-20240826","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/s41374-019-0259-0","article-title":"Dynamic signature of lymphangiogenesis during acute kidney injury and chronic kidney disease","volume":"99","author":"Zarjou","year":"2019","journal-title":"Lab Invest"},{"key":"B7-20240826","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1681\/ASN.2014090856","article-title":"Vascular endothelial growth factor C for polycystic kidney diseases","volume":"27","author":"Huang","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B8-20240826","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1440-1797.2007.00851.x","article-title":"Disturbance of lymph circulation develops renal fibrosis in rats with or without contralateral nephrectomy","volume":"13","author":"Zhang","year":"2008","journal-title":"Nephrology (Carlton)"},{"key":"B9-20240826","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0022-5347(17)63053-2","article-title":"Changes in renal function produced by lymphatic obstruction","volume":"97","author":"Feder","year":"1967","journal-title":"J Urol"},{"key":"B10-20240826","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3389\/fphys.2019.00251","article-title":"Renal lymphatics: Anatomy, physiology, and clinical implications","volume":"10","author":"Russell","year":"2019","journal-title":"Front Physiol"},{"key":"B11-20240826","first-page":"162","article-title":"Syndromic classification of hereditary lymphedema","volume":"36","author":"Northup","year":"2003","journal-title":"Lymphology"},{"key":"B12-20240826","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/emboj\/20.6.1223","article-title":"Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice","volume":"20","author":"Veikkola","year":"2001","journal-title":"EMBO J"},{"key":"B13-20240826","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1126\/science.276.5317.1423","article-title":"Hyperplasia of lymphatic vessels in VEGF-C transgenic mice","volume":"276","author":"Jeltsch","year":"1997","journal-title":"Science"},{"key":"B14-20240826","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.pathmechdis.3.121806.151515","article-title":"Molecular biology and pathology of lymphangiogenesis","volume":"3","author":"Karpanen","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"B15-20240826","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1002\/jcp.27648","article-title":"VEGF-C attenuates renal damage in salt-sensitive hypertension","volume":"234","author":"Beaini","year":"2019","journal-title":"J Cell Physiol"},{"key":"B16-20240826","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1126\/science.282.5390.946","article-title":"Cardiovascular failure in mouse embryos deficient in VEGF receptor-3","volume":"282","author":"Dumont","year":"1998","journal-title":"Science"},{"key":"B17-20240826","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/75997","article-title":"Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema","volume":"25","author":"Karkkainen","year":"2000","journal-title":"Nat Genet"},{"key":"B18-20240826","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000416519","article-title":"The renal lymphatic system: A brief review","volume":"68","author":"O\u2019Morchoe","year":"1988","journal-title":"Contrib Nephrol"},{"key":"B19-20240826","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00441-010-1098-x","article-title":"Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney","volume":"343","author":"Lee","year":"2011","journal-title":"Cell Tissue Res"},{"key":"B20-20240826","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1681\/ASN.2017090962","article-title":"Ascending vasa recta are angiopoietin\/tie2-dependent lymphatic-like vessels","volume":"29","author":"Kenig-Kozlovsky","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B21-20240826","doi-asserted-by":"crossref","first-page":"e0127429","DOI":"10.1371\/journal.pone.0127429","article-title":"Role of Prox1 in the transforming ascending thin limb of Henle\u2019s loop during mouse kidney development","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"B22-20240826","doi-asserted-by":"crossref","first-page":"e48183","DOI":"10.7554\/eLife.48183","article-title":"Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease","volume":"8","author":"Jafree","year":"2019","journal-title":"eLife"},{"key":"B23-20240826","doi-asserted-by":"crossref","first-page":"12677","DOI":"10.1073\/pnas.221449198","article-title":"A model for gene therapy of human hereditary lymphedema","volume":"98","author":"Karkkainen","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B24-20240826","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/s41592-019-0615-4","article-title":"Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution","volume":"16","author":"Chakraborty","year":"2019","journal-title":"Nat Methods"},{"key":"B25-20240826","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.ajpath.2011.12.026","article-title":"ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and platelets","volume":"180","author":"Truman","year":"2012","journal-title":"Am J Pathol"},{"key":"B26-20240826","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.kint.2018.11.042","article-title":"Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease","volume":"95","author":"Landau","year":"2019","journal-title":"Kidney Int"},{"key":"B27-20240826","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1681\/ASN.2017070752","article-title":"Nephronectin regulates mesangial cell adhesion and behavior in glomeruli","volume":"29","author":"Zimmerman","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B28-20240826","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/nprot.2015.085","article-title":"Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging","volume":"10","author":"Susaki","year":"2015","journal-title":"Nat Protoc"},{"key":"B29-20240826","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.kint.2019.02.011","article-title":"Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia\/reperfusion injury","volume":"96","author":"Hasegawa","year":"2019","journal-title":"Kidney Int"},{"key":"B30-20240826","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.bpj.2015.05.013","article-title":"Deconvolution-free subcellular imaging with axially swept light sheet microscopy","volume":"108","author":"Dean","year":"2015","journal-title":"Biophys J"},{"key":"B31-20240826","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s41592-019-0501-0","article-title":"BigStitcher: Reconstructing high-resolution image datasets of cleared and expanded samples","volume":"16","author":"H\u00f6rl","year":"2019","journal-title":"Nat Methods"},{"key":"B32-20240826","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.1128618","article-title":"The molecular architecture of axonemes revealed by cryoelectron tomography","volume":"313","author":"Nicastro","year":"2006","journal-title":"Science"},{"key":"B33-20240826","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1006\/cgip.1994.1042","article-title":"Building skeleton models via 3-D medial surface\/axis thinning algorithms","volume":"56","author":"Lee","year":"1994","journal-title":"CVGIP Graph Models Image Process"},{"key":"B34-20240826","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1109\/TMI.2004.837339","article-title":"Robust quantification of in vitro angiogenesis through image analysis","volume":"24","author":"Niemist\u00f6","year":"2005","journal-title":"IEEE Trans Med Imaging"},{"key":"B35-20240826","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1096\/fj.99-1049com","article-title":"VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues","volume":"14","author":"Partanen","year":"2000","journal-title":"FASEB J"},{"key":"B36-20240826","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2559.2006.02478.x","article-title":"The human renal lymphatics under normal and pathological conditions","volume":"49","author":"Ishikawa","year":"2006","journal-title":"Histopathology"},{"key":"B37-20240826","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1469-7793.2001.0533c.xd","article-title":"Drainage of plasma proteins from the renal medullary interstitium in rats","volume":"536","author":"Tenstad","year":"2001","journal-title":"J Physiol"},{"key":"B38-20240826","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.312765","article-title":"Enhancing renal lymphatic expansion prevents hypertension in mice","volume":"122","author":"Lopez Gelston","year":"2018","journal-title":"Circ Res"},{"key":"B39-20240826","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/HJH.0000000000002349","article-title":"Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice","volume":"38","author":"Balasubbramanian","year":"2020","journal-title":"J Hypertens"},{"key":"B40-20240826","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1017\/erm.2014.18","article-title":"Lymphangiogenesis in renal diseases: Passive bystander or active participant?","volume":"16","author":"Yazdani","year":"2014","journal-title":"Expert Rev Mol Med"},{"key":"B41-20240826","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.devcel.2019.10.005","article-title":"Single-cell profiling reveals sex, lineage, and regional diversity in the mouse kidney","volume":"51","author":"Ransick","year":"2019","journal-title":"Dev Cell"},{"key":"B42-20240826","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41581-020-0260-2","article-title":"Targeting angiogenesis and lymphangiogenesis in kidney disease","volume":"16","author":"Tanabe","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B43-20240826","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/ckj\/sfv064","article-title":"Lymphatic disorders after renal transplantation: New insights for an old complication","volume":"8","author":"Ranghino","year":"2015","journal-title":"Clin Kidney J"},{"key":"B44-20240826","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3181\/00379727-146-38094","article-title":"Test of the safety valve function of the renal lymphatic vessels","volume":"146","author":"Bell","year":"1974","journal-title":"Proc Soc Exp Biol Med"},{"key":"B45-20240826","first-page":"F344","article-title":"Renal interstitial pressure and sodium excretion during hilar lymphatic ligation","volume":"247","author":"Wilcox","year":"1984","journal-title":"Am J Physiol"},{"key":"B46-20240826","doi-asserted-by":"crossref","first-page":"eaaw5075","DOI":"10.1126\/sciadv.aaw5075","article-title":"Lymphangiogenesis in kidney and lymph node mediates renal inflammation and fibrosis","volume":"5","author":"Pei","year":"2019","journal-title":"Sci Adv"},{"key":"B47-20240826","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/ajplegacy.1943.138.3.553","article-title":"Observations concerning the origin of renal lymph","volume":"138","author":"Kaplan","year":"1943","journal-title":"Am J Physiol"},{"key":"B48-20240826","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/BF01944556","article-title":"Access of reabsorbed glucose to renal lymph","volume":"38","author":"Cook","year":"1982","journal-title":"Experientia"},{"key":"B49-20240826","first-page":"285","article-title":"Effects of renal lymphatic occlusion and venous constriction on renal function","volume":"78","author":"Stolarczyk","year":"1975","journal-title":"Am J Pathol"},{"key":"B50-20240826","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/ki.2011.464","article-title":"Transforming growth factor-\u03b2 induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction","volume":"81","author":"Suzuki","year":"2012","journal-title":"Kidney Int"},{"key":"B51-20240826","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/ki.2008.661","article-title":"Lymphatic vessels develop during tubulointerstitial fibrosis","volume":"75","author":"Sakamoto","year":"2009","journal-title":"Kidney Int"},{"key":"B52-20240826","doi-asserted-by":"crossref","first-page":"14098","DOI":"10.1073\/pnas.0511200103","article-title":"Secondary lymphoid tissue chemokine (SLC\/CCL21)\/CCR7 signaling regulates fibrocytes in renal fibrosis","volume":"103","author":"Sakai","year":"2006","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2021010061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:25:38Z","timestamp":1786130738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2021010061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2021010061","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-01-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}