{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:06:14Z","timestamp":1786133174963,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK092475"],"award-info":[{"award-number":["R01DK092475"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Sustained (or overt) diabetes mellitus after kidney transplantation is strongly associated with hyperglycemia during the early perioperative period. In a multicenter trial with 263 participants randomized to strict blood glucose monitoring and an early basal insulin intervention versus control (a more liberal approach consisting of sporadic corrections of hyperglycemia and otherwise oral antidiabetics), overt post-transplantation diabetes mellitus (PTDM) was ascertained by antidiabetic treatment and an oral glucose tolerance test (2 hour glucose \u2265200 mg\/dl). The intervention resulted in modestly reduced PTDM rates at 12 months and 24 months at the cost of higher rates of hypoglycemia. In a per-protocol analysis that excluded protocol violators and accounted for baseline differences in polycystic kidney disease, the reduction in PTDM at 12 months was significant, suggesting the approach merits further study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post-transplantation diabetes mellitus (PTDM) might be preventable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This open-label, multicenter randomized trial compared 133 kidney transplant recipients given intermediate-acting insulin isophane for postoperative afternoon glucose \u2265140 mg\/dl with 130 patients given short-acting insulin for fasting glucose \u2265200 mg\/dl (control). The primary end point was PTDM (antidiabetic treatment or oral glucose tolerance test\u2013derived 2 hour glucose \u2265200 mg\/dl) at month 12 post-transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the intention-to-treat population, PTDM rates at 12 months were 12.2% and 14.7% in treatment versus control groups, respectively (odds ratio [OR], 0.82; 95% confidence interval [95% CI], 0.39 to 1.76) and 13.4% versus 17.4%, respectively, at 24 months (OR, 0.71; 95% CI, 0.34 to 1.49). In the per-protocol population, treatment resulted in reduced odds for PTDM at 12 months (OR, 0.40; 95% CI, 0.16 to 1.01) and 24 months (OR, 0.54; 95% CI, 0.24 to 1.20). After adjustment for polycystic kidney disease, per-protocol ORs for PTDM (treatment versus controls) were 0.21 (95% CI, 0.07 to 0.62) at 12 months and 0.35 (95% CI, 0.14 to 0.87) at 24 months. Significantly more hypoglycemic events (mostly asymptomatic or mildly symptomatic) occurred in the treatment group versus the control group. Within the treatment group, nonadherence to the insulin initiation protocol was associated with significantly higher odds for PTDM at months 12 and 24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At low overt PTDM incidence, the primary end point in the intention-to-treat population did not differ significantly between treatment and control groups. In the per-protocol analysis, early basal insulin therapy resulted in significantly higher hypoglycemia rates but reduced odds for overt PTDM\u2014a significant reduction after adjustment for baseline differences\u2014suggesting the intervention merits further study.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial registration number:<\/jats:bold>\n                      NCT03507829\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2021010127","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T15:43:42Z","timestamp":1627659822000},"page":"2083-2098","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":40,"title":["Early Postoperative Basal Insulin Therapy versus Standard of Care for the Prevention of Diabetes Mellitus after Kidney Transplantation: A Multicenter Randomized Trial"],"prefix":"10.1681","volume":"32","clinical-trial-number":[{"clinical-trial-number":"nct03507829","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-274X","authenticated-orcid":false,"given":"Elisabeth","family":"Schwaiger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Internal Medicine II, Kepler University Hospital, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-9085","authenticated-orcid":false,"given":"Simon","family":"Krenn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Kurnikowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Bergfeld","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Nephrology and Medical Intensive Care, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"P\u00e9rez-S\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Internal Medicine and Gastroenterology, Hospital Vienna North, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Topitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Pediatrics and Adolescent Medicine, Clinic Ottakring, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Pneumology, Clinic Ottakring, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"H\u00f6dlmoser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Epidemiology, Medical University of Vienna, Vienna, 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