{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:40:49Z","timestamp":1792755649396,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC\/81770856"],"award-info":[{"award-number":["NSFC\/81770856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC\/81970644"],"award-info":[{"award-number":["NSFC\/81970644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC\/81601541"],"award-info":[{"award-number":["NSFC\/81601541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC\/81925006"],"award-info":[{"award-number":["NSFC\/81925006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Heilongjiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["H201496"],"award-info":[{"award-number":["H201496"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Heilongjiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LH2020H067"],"award-info":[{"award-number":["LH2020H067"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Province Innovation Centre for Science and Technology Program","doi-asserted-by":"publisher","award":["JPIC\/20190902013TC"],"award-info":[{"award-number":["JPIC\/20190902013TC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000291","name":"Kidney Research UK and the Mayer Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000291","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Accumulating evidence implicates microRNAs in IgA nephropathy (IgAN), which is a common primary GN in which aberrant IgA aggregated with complement 3, with or without IgG\/IgM is deposited in glomerular mesangium. We showed, in a mouse model, that miR-23b deficiency induced an IgA nephropathy-like disease, marked by mesangial IgA and C3 deposition, increased proteinuria, elevated serum IgA levels, and development of high blood pressure. Elevations in serum IgA levels and mesangial IgA deposition were associated with dysregulated mucosal IgA synthesis through targeting the activation-induced cytidine deaminase gene in the gut. miR-23b deficiency-induced dysfunctional kidney effects were likely mediated through regulation of expression of gremlin 2 (Grem2) and the transferrin receptor (Tfrc), which weexamined in human mesangial cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>IgA nephropathy (IgAN) is the most common primary GN worldwide. Circulating immune complexes form that are prone to deposition in the mesangium, where they trigger glomerular inflammation. A growing body of evidence suggests that dysregulated expression of microRNAs in IgAN may play a significant role in establishing the disease phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We generated single miR-23b-3p(miR-23b) knockout mice using CRISPR-Cas9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In humans, miR-23b levels are downregulated in kidney biopsies and sera of patients with IgAN, and serum miR-23b levels are negatively correlated with serum IgA1 levels. We show that miR-23b\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice develop an IgAN-like phenotype of mesangial IgA and C3 deposition associated with development of albuminuria, hypertension, an elevated serum creatinine, and dysregulated mucosal IgA synthesis. Dysregulation of IgA production is likely mediated by the loss of miR-23b\u2013mediated suppression of activation-induced cytidine deaminase in mucosal B cells. In addition, we show that loss of miR-23b increases the susceptibility of the kidney to progressive fibrosis through loss of regulation of expression of gremlin 2 and IgA accumulation through downregulation of the transferrin receptor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest an indispensable role for miR-23b in kidney disease, and in particular, IgAN. miR-23b may in the future offer a novel therapeutic target for the treatment of IgAN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2021010133","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T14:10:18Z","timestamp":1630678218000},"page":"2561-2578","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["MicroRNA-23b-3p Deletion Induces an IgA Nephropathy-like Disease Associated with Dysregulated Mucosal IgA Synthesis"],"prefix":"10.1681","volume":"32","author":[{"given":"Hongzhi","family":"Li","sequence":"first","affiliation":[{"name":"Nephrosis Precision Medicine Innovation Center, University of Beihua School of Medicine, Beihua University, Jilin 132011, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitian","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Affiliated Hong Qi Hospital, Mudanjiang Medical University, Mudanjiang 157011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchuang","family":"Ma","sequence":"additional","affiliation":[{"name":"Nephrosis Precision Medicine Innovation Center, University of Beihua School of Medicine, Beihua University, Jilin 132011, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Sun","sequence":"additional","affiliation":[{"name":"Nephrosis Precision Medicine Innovation Center, University of Beihua School of Medicine, Beihua University, Jilin 132011, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiusong","family":"Yao","sequence":"additional","affiliation":[{"name":"Nephrology Department of Jinlin Central Hospital, Jinlin 132011, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Li","sequence":"additional","affiliation":[{"name":"Nephrosis Precision Medicine Innovation Center, University of Beihua School of Medicine, Beihua University, Jilin 132011, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella Z.A","family":"Pawluczyk","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Electron Microscopy Center, Basic Medical Science College, Harbin Medical University, Harbin, 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-7229","authenticated-orcid":false,"given":"Jonathan","family":"Barratt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Lv","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, 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