{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:16:55Z","timestamp":1791548215394,"version":"4.3.4"},"reference-count":100,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0450"],"award-info":[{"award-number":["W81XWH-16-1-0450"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["GRANT12019690"],"award-info":[{"award-number":["GRANT12019690"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      HIV-associated nephropathy (HIVAN) is a well-recognized complication of HIV infection that manifests with collapsing FSGS, tubular microcysts, interstitial fibrosis, and inflammation. Genetic predisposition to human HIVAN has been associated with variants of\n                      <jats:italic toggle=\"yes\">APOL1<\/jats:italic>\n                      ; however, the\n                      <jats:italic toggle=\"yes\">APOL1<\/jats:italic>\n                      risk alleles are incompletely penetrant, and it is very likely there are other common and rare risk genetic factors. Studying a validated mouse model of HIVAN, we found large differences in nephropathy susceptibility and severity among inbred strains. A genome-wide association study identified a major locus on Chr. 13 and suggests\n                      <jats:italic toggle=\"yes\">Ssbp2<\/jats:italic>\n                      as the candidate gene conferring susceptibility to HIVAN in the mouse. Identification of novel genes associated with HIVAN and other virally mediated glomerulopathies should foster the design of innovative therapeutics and better patient management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To gain insight into the pathogenesis of collapsing glomerulopathy, a rare form of FSGS that often arises in the setting of viral infections, we performed a genome-wide association study (GWAS) among inbred mouse strains using a murine model of HIV-1 associated nephropathy (HIVAN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We first generated F1 hybrids between HIV-1 transgenic mice on the FVB\/NJ background and 20 inbred laboratory strains. Analysis of histology, BUN, and urinary NGAL demonstrated marked phenotypic variation among the transgenic F1 hybrids, providing strong evidence for host genetic factors in the predisposition to nephropathy. A GWAS in 365 transgenic F1 hybrids generated from these 20 inbred strains was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified a genome-wide significant locus on chromosome 13-C3 and multiple additional suggestive loci. Crossannotation of the Chr. 13 locus, including single-cell transcriptomic analysis of wildtype and HIV-1 transgenic mouse kidneys, nominated\n                      <jats:italic toggle=\"yes\">Ssbp2<\/jats:italic>\n                      as the most likely candidate gene.\n                      <jats:italic toggle=\"yes\">Ssbp2<\/jats:italic>\n                      is highly expressed in podocytes, encodes a transcriptional cofactor that interacts with LDB1 and LMX1B, which are both previously implicated in FSGS. Consistent with these data, older\n                      <jats:italic toggle=\"yes\">Ssbp2<\/jats:italic>\n                      null mice spontaneously develop glomerulosclerosis, tubular casts, interstitial fibrosis, and inflammation, similar to the HIVAN mouse model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate the utility of GWAS in mice to uncover host genetic factors for rare kidney traits and suggest\n                      <jats:italic toggle=\"yes\">Ssbp2<\/jats:italic>\n                      as susceptibility gene for HIVAN, potentially acting\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      the LDB1-LMX1B transcriptional network.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2021040543","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T11:45:23Z","timestamp":1639136723000},"page":"108-120","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus"],"prefix":"10.1681","volume":"33","author":[{"given":"Nicholas J.","family":"Steers","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yask","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivette D.","family":"D\u2019Agati","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Y.","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"DeMaria","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-4769","authenticated-orcid":false,"given":"Anna","family":"Mo","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New 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