{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:38:08Z","timestamp":1789414688778,"version":"build-2803163510"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21874100"],"award-info":[{"award-number":["21874100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017YFA0504102"],"award-info":[{"award-number":["2017YFA0504102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","award":["19JCJQJC63800"],"award-info":[{"award-number":["19JCJQJC63800"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emerging evidence indicates that epigenetic modulation of gene expression plays a key role in the progression of autosomal dominant polycystic kidney disease (ADPKD). However, the molecular basis for how the altered epigenome modulates transcriptional responses, and thereby disease progression in ADPKD, remains largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Kidneys from control and ADPKD mice were examined for the expression of CDYL and histone acylations. CDYL expression and its correlation with disease severity were analyzed in a cohort of patients with ADPKD.\n                      <jats:italic toggle=\"yes\">Cdyl<\/jats:italic>\n                      transgenic mice were crossed with\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      knockout mice to explore CDYL\u2019s role in ADPKD progression. Integrated cistromic and transcriptomic analyses were performed to identify direct CDYL target genes. High-sensitivity mass spectrometry analyses were undertaken to characterize CDYL-regulated histone lysine crotonylations (Kcr). Biochemical analysis and zebrafish models were used for investigating CDYL phase separation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CDYL was downregulated in ADPKD kidneys, accompanied by an increase of histone Kcr. Genetic overexpression of\n                      <jats:italic toggle=\"yes\">Cdyl<\/jats:italic>\n                      reduced histone Kcr and slowed cyst growth. We identified CDYL-regulated cyst-associated genes, whose downregulation depended on CDYL-mediated suppression of histone Kcr. CDYL assembled nuclear condensates through liquid-liquid phase separation in cultured kidney epithelial cells and in normal kidney tissues. The phase-separating capacity of CDYL was required for efficient suppression of locus-specific histone Kcr, of expression of its target genes, and of cyst growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results elucidate a mechanism by which CDYL nuclear condensation links histone Kcr to transcriptional responses and cystogenesis in ADPKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2021111425","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T17:30:31Z","timestamp":1659461431000},"page":"1708-1725","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":41,"title":["Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease"],"prefix":"10.1681","volume":"33","author":[{"given":"Lin","family":"Dang","sequence":"first","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhan","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China"},{"name":"School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Tian","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-7955","authenticated-orcid":false,"given":"Peipei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nankai University School of Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nankai University School of Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-9241","authenticated-orcid":false,"given":"Shengqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-5087","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Renal Division, Peking University First Hospital; Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education of China, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2800-0531","authenticated-orcid":false,"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-9547","authenticated-orcid":false,"given":"Yupeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"B1-20250823","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(18)32782-X","article-title":"Autosomal dominant polycystic kidney disease","volume":"393","author":"Cornec-Le Gall","year":"2019","journal-title":"Lancet"},{"key":"B2-20250823","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-018-0047-y","article-title":"Polycystic kidney disease","volume":"4","author":"Bergmann","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"B3-20250823","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI72272","article-title":"Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease","volume":"124","author":"Harris","year":"2014","journal-title":"J Clin Invest"},{"key":"B4-20250823","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1083\/jcb.201006173","article-title":"The cell biology of polycystic kidney disease","volume":"191","author":"Chapin","year":"2010","journal-title":"J Cell Biol"},{"key":"B5-20250823","doi-asserted-by":"crossref","first-page":"109509","DOI":"10.1016\/j.cellsig.2019.109509","article-title":"Epigenetics and cell cycle regulation in cystogenesis","volume":"68","author":"Li","year":"2020","journal-title":"Cell Signal"},{"key":"B7-20250823","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2011.08.008","article-title":"Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification","volume":"146","author":"Tan","year":"2011","journal-title":"Cell"},{"key":"B8-20250823","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1074\/mcp.M700021-MCP200","article-title":"Lysine propionylation and butyrylation are novel post-translational modifications in histones","volume":"6","author":"Chen","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"B9-20250823","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1074\/mcp.M111.015875","article-title":"Lysine succinylation and lysine malonylation in histones","volume":"11","author":"Xie","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"B10-20250823","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"B11-20250823","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2016.03.036","article-title":"Metabolic regulation of gene expression by histone lysine \u03b2-hydroxybutyrylation","volume":"62","author":"Xie","year":"2016","journal-title":"Mol Cell"},{"key":"B12-20250823","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrm.2016.140","article-title":"Metabolic regulation of gene expression through histone acylations","volume":"18","author":"Sabari","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B13-20250823","first-page":"1","article-title":"Histone acylation beyond acetylation: Terra incognita in chromatin biology","volume":"17","author":"Rousseaux","year":"2015","journal-title":"Cell J"},{"key":"B14-20250823","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.molcel.2016.06.038","article-title":"Diverse activities of histone acylations connect metabolism to chromatin function","volume":"63","author":"Dutta","year":"2016","journal-title":"Mol Cell"},{"key":"B15-20250823","doi-asserted-by":"crossref","first-page":"624914","DOI":"10.3389\/fcell.2021.624914","article-title":"The regulation and function of histone crotonylation","volume":"9","author":"Ntorla","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B16-20250823","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13072-021-00385-9","article-title":"Histone crotonylation-centric gene regulation","volume":"14","author":"Li","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"B17-20250823","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molcel.2016.03.028","article-title":"Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain","volume":"62","author":"Li","year":"2016","journal-title":"Mol Cell"},{"key":"B18-20250823","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molcel.2015.02.029","article-title":"Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation","volume":"58","author":"Sabari","year":"2015","journal-title":"Mol Cell"},{"key":"B19-20250823","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.stem.2020.12.009","article-title":"Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells","volume":"28","author":"Fang","year":"2021","journal-title":"Cell Stem Cell"},{"key":"B20-20250823","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCULATIONAHA.120.049438","article-title":"Short-chain enoyl-CoA hydratase mediates histone crotonylation and contributes to cardiac homeostasis","volume":"143","author":"Tang","year":"2021","journal-title":"Circulation"},{"key":"B21-20250823","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1242\/dmm.024455","article-title":"Histone lysine crotonylation during acute kidney injury in mice","volume":"9","author":"Ruiz-Andres","year":"2016","journal-title":"Dis Model Mech"},{"key":"B22-20250823","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1172\/JCI98071","article-title":"HIV latency is reversed by ACSS2-driven histone crotonylation","volume":"128","author":"Jiang","year":"2018","journal-title":"J Clin Invest"},{"key":"B23-20250823","doi-asserted-by":"crossref","first-page":"42414","DOI":"10.1074\/jbc.M111.271064","article-title":"Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27","volume":"286","author":"Zhang","year":"2011","journal-title":"J Biol Chem"},{"key":"B24-20250823","doi-asserted-by":"crossref","first-page":"35049","DOI":"10.1074\/jbc.M109.052332","article-title":"Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association","volume":"284","author":"Franz","year":"2009","journal-title":"J Biol Chem"},{"key":"B25-20250823","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/sj.embor.embor917","article-title":"Cdyl: A new transcriptional co-repressor","volume":"4","author":"Caron","year":"2003","journal-title":"EMBO Rep"},{"key":"B26-20250823","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.molcel.2008.10.025","article-title":"CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation","volume":"32","author":"Mulligan","year":"2008","journal-title":"Mol Cell"},{"key":"B27-20250823","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.molcel.2017.07.011","article-title":"Chromodomain protein CDYL acts as a crotonyl-CoA hydratase to regulate histone crotonylation and spermatogenesis","volume":"67","author":"Liu","year":"2017","journal-title":"Mol Cell"},{"key":"B28-20250823","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.biopsych.2018.11.025","article-title":"Chromodomain Y-like protein-mediated histone crotonylation regulates stress-induced depressive behaviors","volume":"85","author":"Liu","year":"2019","journal-title":"Biol Psychiatry"},{"key":"B29-20250823","doi-asserted-by":"crossref","first-page":"166624","DOI":"10.1016\/j.jmb.2020.08.009","article-title":"Enzymatic reactions inside biological condensates","volume":"433","author":"Zhang","year":"2021","journal-title":"J Mol Biol"},{"key":"B30-20250823","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ceb.2020.12.012","article-title":"The role of liquid-liquid phase separation in regulating enzyme activity","volume":"69","author":"O\u2019Flynn","year":"2021","journal-title":"Curr Opin Cell Biol"},{"key":"B31-20250823","doi-asserted-by":"crossref","first-page":"32782","DOI":"10.1021\/acsami.8b07573","article-title":"Membraneless compartmentalization facilitates enzymatic cascade reactions and reduces substrate inhibition","volume":"10","author":"Kojima","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"B32-20250823","doi-asserted-by":"crossref","first-page":"eaaf4382","DOI":"10.1126\/science.aaf4382","article-title":"Liquid phase condensation in cell physiology and disease","volume":"357","author":"Shin","year":"2017","journal-title":"Science"},{"key":"B33-20250823","doi-asserted-by":"crossref","first-page":"F397","DOI":"10.1152\/ajprenal.00310.2002","article-title":"Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts","volume":"285","author":"Loghman-Adham","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"B34-20250823","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1681\/ASN.2005080830","article-title":"Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction","volume":"17","author":"Nauli","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"B35-20250823","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1681\/ASN.2018010074","article-title":"Interactions between macrophages and cyst-lining epithelial cells promote kidney cyst growth in Pkd1-deficient mice","volume":"29","author":"Yang","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B36-20250823","doi-asserted-by":"crossref","first-page":"100053","DOI":"10.1074\/mcp.RA120.002150","article-title":"Systematic proteome and lysine succinylome analysis reveals enhanced cell migration by hyposuccinylation in esophageal squamous cell carcinoma","volume":"20","author":"Guo","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"B37-20250823","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1021\/acs.jproteome.8b00133","article-title":"EpiProfile 2.0: A computational platform for processing epi-proteomics mass spectrometry data","volume":"17","author":"Yuan","year":"2018","journal-title":"J Proteome Res"},{"key":"B38-20250823","doi-asserted-by":"crossref","first-page":"eaaw3593","DOI":"10.1126\/sciadv.aaw3593","article-title":"Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease","volume":"5","author":"Sun","year":"2019","journal-title":"Sci Adv"},{"key":"B39-20250823","doi-asserted-by":"crossref","first-page":"eaba3613","DOI":"10.1126\/scitranslmed.aba3613","article-title":"Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease","volume":"12","author":"Lu","year":"2020","journal-title":"Sci Transl Med"},{"key":"B40-20250823","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.kint.2016.10.039","article-title":"STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease","volume":"91","author":"Fragiadaki","year":"2017","journal-title":"Kidney Int"},{"key":"B41-20250823","doi-asserted-by":"crossref","first-page":"133785","DOI":"10.1172\/jci.insight.133785","article-title":"Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression","volume":"5","author":"Lakhia","year":"2020","journal-title":"JCI Insight"},{"key":"B42-20250823","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/ki.2010.228","article-title":"CD14 : A candidate biomarker for the prognosis of polycystic kidney disease","volume":"78","author":"Vanden Heuvel","year":"2010","journal-title":"Kidney Int"},{"key":"B43-20250823","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2009.10.005","article-title":"Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis","volume":"79","author":"Sadanandam","year":"2010","journal-title":"Microvasc Res"},{"key":"B44-20250823","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.ajpath.2016.04.015","article-title":"Regulation of collagen V expression and epithelial-mesenchymal transition by mir-185 AND mir-186 DURING idiopathic pulmonary fibrosis","volume":"186","author":"Lei","year":"2016","journal-title":"Am J Pathol"},{"key":"B45-20250823","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/CIRCRESAHA.119.315428","article-title":"T-cell-derived mirna-214 mediates perivascular fibrosis in hypertension","volume":"126","author":"Nosalski","year":"2020","journal-title":"Circ Res"},{"key":"B46-20250823","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm.2017.7","article-title":"Biomolecular condensates: organizers of cellular biochemistry","volume":"18","author":"Banani","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B47-20250823","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","article-title":"Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates","volume":"176","author":"Alberti","year":"2019","journal-title":"Cell"},{"key":"B48-20250823","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.3390\/ijms21176208","article-title":"Relevance of electrostatic charges in compactness, aggregation, and phase separation of intrinsically disordered proteins","volume":"21","author":"Bianchi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B49-20250823","doi-asserted-by":"crossref","first-page":"21819","DOI":"10.1073\/pnas.0911987106","article-title":"Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models","volume":"106","author":"Cao","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B50-20250823","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrg.2016.98","article-title":"Transition states and cell fate decisions in epigenetic landscapes","volume":"17","author":"Moris","year":"2016","journal-title":"Nat Rev Genet"},{"key":"B51-20250823","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41580-021-00335-z","article-title":"Direct cell reprogramming: approaches, mechanisms and progress","volume":"22","author":"Wang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B52-20250823","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ki.1993.17","article-title":"Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation?","volume":"43","author":"Calvet","year":"1993","journal-title":"Kidney Int"},{"key":"B53-20250823","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physrev.00026.2016","article-title":"Posttranslational modification as a critical determinant of cytoplasmic innate immune recognition","volume":"97","author":"Baker","year":"2017","journal-title":"Physiol Rev"},{"key":"B54-20250823","doi-asserted-by":"crossref","first-page":"e52774","DOI":"10.15252\/embr.202152774","article-title":"Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism","volume":"22","author":"Nitsch","year":"2021","journal-title":"EMBO Rep"},{"key":"B55-20250823","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41581-018-0051-1","article-title":"Metabolism and mitochondria in polycystic kidney disease research and therapy","volume":"14","author":"Padovano","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"B56-20250823","doi-asserted-by":"crossref","first-page":"109495","DOI":"10.1016\/j.cellsig.2019.109495","article-title":"Metabolic reprogramming and the role of mitochondria in polycystic kidney disease","volume":"67","author":"Podrini","year":"2020","journal-title":"Cell Signal"},{"key":"B57-20250823","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41581-019-0183-y","article-title":"The pathobiology of polycystic kidney disease from a metabolic viewpoint","volume":"15","author":"Menezes","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"B58-20250823","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1681\/ASN.2015020132","article-title":"Food restriction ameliorates the development of polycystic kidney disease","volume":"27","author":"Warner","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B59-20250823","doi-asserted-by":"crossref","first-page":"F726","DOI":"10.1152\/ajprenal.00551.2015","article-title":"A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease","volume":"310","author":"Kipp","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"B60-20250823","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1681\/ASN.2015030231","article-title":"2-deoxy-d-glucose ameliorates PKD progression","volume":"27","author":"Chiaravalli","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B61-20250823","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.3092","article-title":"Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy","volume":"19","author":"Rowe","year":"2013","journal-title":"Nat Med"},{"key":"B62-20250823","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.cmet.2021.03.024","article-title":"A methionine-Mettl3-N-6-methyladenosine axis promotes polycystic kidney disease","volume":"33","author":"Ramalingam","year":"2021","journal-title":"Cell Metab"},{"key":"B63-20250823","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.cmet.2019.09.012","article-title":"Ketosis ameliorates renal cyst growth in polycystic kidney disease","volume":"30","author":"Torres","year":"2019","journal-title":"Cell Metab"},{"key":"B64-20250823","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.tibs.2016.05.013","article-title":"Metabolic enzymes moonlighting in the nucleus: Metabolic regulation of gene transcription","volume":"41","author":"Boukouris","year":"2016","journal-title":"Trends Biochem Sci"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2021111425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:29:49Z","timestamp":1786130989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2021111425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2021111425","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2021-11-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}