{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:53:21Z","timestamp":1792644801748,"version":"4.5.0"},"reference-count":76,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["VOLSIGNAL (#740537)"],"award-info":[{"award-number":["VOLSIGNAL (#740537)"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1365, B02"],"award-info":[{"award-number":["SFB 1365, B02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001706","name":"Fondation Louis-Jeantet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Volume-regulated anion channels (VRACs) are heterohexamers of LRRC8A with LRRC8B, -C, -D, or -E in various combinations. Depending on the subunit composition, these swelling-activated channels conduct chloride, amino acids, organic osmolytes, and drugs. Despite VRACs\u2019 role in cell volume regulation, and large osmolarity changes in the kidney, neither the localization nor the function of VRACs in the kidney is known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Mice expressing epitope-tagged LRRC8 subunits were used to determine the renal localization of all VRAC subunits. Mice carrying constitutive deletions of\n                      <jats:italic toggle=\"yes\">Lrrc8b<\/jats:italic>\n                      \u2013\n                      <jats:italic toggle=\"yes\">e<\/jats:italic>\n                      , or with inducible or cell-specific ablation of\n                      <jats:italic toggle=\"yes\">Lrrc8a<\/jats:italic>\n                      , were analyzed to assess renal functions of VRACs. Analysis included histology, urine and serum parameters in different diuresis states, and metabolomics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The kidney expresses all five VRAC subunits with strikingly distinct localization. Whereas LRRC8C is exclusively found in vascular endothelium, all other subunits are found in the nephron. LRRC8E is specific for intercalated cells, whereas LRRC8A, LRRC8B, and LRRC8D are prominent in basolateral membranes of proximal tubules. Conditional deletion of LRRC8A in proximal but not distal tubules and constitutive deletion of LRRC8D cause proximal tubular injury, increased diuresis, and mild Fanconi-like symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VRAC\/LRRC8 channels are crucial for the function and integrity of proximal tubules, but not for more distal nephron segments despite their larger need for volume regulation. LRRC8A\/D channels may be required for the basolateral exit of many organic compounds, including cellular metabolites, in proximal tubules. Proximal tubular injury likely results from combined accumulation of several transported molecules in the absence of VRAC channels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2021111458","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T10:25:21Z","timestamp":1656671121000},"page":"1528-1545","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Renal Deletion of LRRC8\/VRAC Channels Induces Proximal Tubulopathy"],"prefix":"10.1681","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-7345","authenticated-orcid":false,"given":"Karen I.","family":"L\u00f3pez-Cayuqueo","sequence":"first","affiliation":[{"name":"Leibniz-Forschungsinstitut f\u00fcr Molekulare Pharmakologie (FMP) and Max-Delbr\u00fcck-Centrum f\u00fcr Molekulare Medizin (MDC), Berlin, 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osmolytes","volume":"71","author":"Garcia-Perez","year":"1991","journal-title":"Physiol Rev"},{"key":"B8-20250823","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1681\/ASN.V32121","article-title":"How tonicity regulates gene expression","volume":"3","author":"Burg","year":"1992","journal-title":"J Am Soc Nephrol"},{"key":"B9-20250823","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/physrev.00056.2006","article-title":"Cellular response to hyperosmotic stresses","volume":"87","author":"Burg","year":"2007","journal-title":"Physiol Rev"},{"key":"B10-20250823","first-page":"F154","article-title":"In vivo osmoregulation of aldose reductase mRNA, protein, and sorbitol in renal medulla","volume":"258","author":"Cowley","year":"1990","journal-title":"Am J Physiol"},{"key":"B11-20250823","doi-asserted-by":"crossref","first-page":"8230","DOI":"10.1073\/pnas.89.17.8230","article-title":"Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine 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II. Kidney-specific activity in transgenic mice","volume":"277","author":"Igarashi","year":"1999","journal-title":"Am J Physiol"},{"key":"B36-20250823","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1172\/JCI200113077","article-title":"Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis","volume":"108","author":"Isermann","year":"2001","journal-title":"J Clin Invest"},{"key":"B37-20250823","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nm.1865","article-title":"An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice","volume":"14","author":"Traykova-Brauch","year":"2008","journal-title":"Nat Med"},{"key":"B38-20250823","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/0310057X8701500214","article-title":"For calculating osmolality, the simplest formula is the 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Clin Invest"},{"key":"B52-20250823","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tem.2007.11.001","article-title":"Copeptin: Clinical use of a new biomarker","volume":"19","author":"Morgenthaler","year":"2008","journal-title":"Trends Endocrinol Metab"},{"key":"B53-20250823","doi-asserted-by":"crossref","first-page":"F744","DOI":"10.1152\/ajprenal.00010.2017","article-title":"Aquaporin-2 membrane targeting: Still a conundrum","volume":"312","author":"Olesen","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"B54-20250823","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.semnephrol.2009.03.008","article-title":"The physiology of urinary concentration: An update","volume":"29","author":"Sands","year":"2009","journal-title":"Semin Nephrol"},{"key":"B55-20250823","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1097\/01.ASN.0000016444.90348.50","article-title":"Epithelial-specific Cre\/lox recombination in the developing kidney 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