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Andersen Foundation","doi-asserted-by":"publisher","award":["Award #21"],"award-info":[{"award-number":["Award #21"]}],"id":[{"id":"10.13039\/100017909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"US Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK 125252"],"award-info":[{"award-number":["DK 125252"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Full-length parathyroid hormone (PTH 1\u201384) is crucial for the regulation of calcium and phosphate homeostasis and bone remodeling. PTH 1\u201384 is metabolized into various PTH fragments, which are measured with varying levels of efficiency by PTH immunoassays. These PTH fragments, which increase in serum as CKD progresses, could potentially modulate the effects of PTH 1\u201384 and contribute to CKD-associated bone disorders. To obtain a true biologic representation of total PTH bioactivity, it is necessary to measure not only PTH 1\u201384 but also PTH fragments that are present in circulation. Traditional second-generation PTH immunoassays collectively measure PTH 1\u201384, PTH fragments, and post-translationally modified PTH 1\u201384, making it difficult to accurately predict the character of underlying renal osteodystrophy. This review highlights current advances in methods available for PTH measurement and the clinical relevance of PTH fragments in CKD. We emphasize the usefulness of mass spectrometry as a potential reference method for PTH measurement.<\/jats:p>","DOI":"10.1681\/asn.2022010036","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T13:00:38Z","timestamp":1649422838000},"page":"1448-1458","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["High-Resolution Mass Spectrometry for the Measurement of PTH and PTH Fragments: Insights into PTH Physiology and Bioactivity"],"prefix":"10.1681","volume":"33","author":[{"given":"Candice Z.","family":"Ulmer","sequence":"first","affiliation":[{"name":"Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-5874","authenticated-orcid":false,"given":"Kittrawee","family":"Kritmetapak","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder J.","family":"Singh","sequence":"additional","affiliation":[{"name":"Immunochemical Core Laboratory, Mayo Clinic, Rochester, Minnesota"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert W.","family":"Vesper","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3497-3057","authenticated-orcid":false,"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"B1-20250823","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/clinchem\/hvab013","article-title":"Chemical characterization and quantification of circulating intact PTH and PTH fragments by high-resolution mass spectrometry in chronic renal failure","volume":"67","author":"Kritmetapak","year":"2021","journal-title":"Clin 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