{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:54:34Z","timestamp":1789667674006,"version":"4.0.1"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","funder":[{"name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","award":["U01AI063594"],"award-info":[{"award-number":["U01AI063594"]}]},{"name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","award":["UM2AI117870"],"award-info":[{"award-number":["UM2AI117870"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Peritransplant TNF blockade with infliximab should not be used in recipients of deceased-donor kidney transplants due to lack of efficacy and an increased incidence of BK virus infection, according to results of a randomized controlled clinical trial. Our results underscore the need for properly controlled and powered trials to avoid falsely accepting unproven therapeutics and reporting incorrect low adverse event rates derived from small, uncontrolled experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Ischemia-reperfusion (IR) of a kidney transplant (KTx) upregulates TNF\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      production that amplifies allograft inflammation and may negatively affect transplant outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We tested the effects of blocking TNF peri-KTx\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      a randomized, double-blind, placebo-controlled, 15-center, phase 2 clinical trial. A total of 225 primary transplant recipients of deceased-donor kidneys (KTx; 38.2% Black\/African American, 44% White) were randomized to receive intravenous infliximab (IFX) 3 mg\/kg or saline placebo (PLBO) initiated before kidney reperfusion. All patients received rabbit anti-thymocyte globulin induction and maintenance immunosuppression (IS) with tacrolimus, mycophenolate mofetil, and prednisone. The primary end point was the difference between groups in mean 24-month eGFR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no difference in the primary end point of 24-month eGFR between IFX (52.45 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI, 48.38 to 56.52) versus PLBO (57.35 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI, 53.18 to 61.52;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.1). There were no significant differences between groups in rates of delayed graft function, biopsy-proven acute rejection (BPAR), development of\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      donor-specific antibodies, or graft loss\/death. Immunosuppression did not differ, and day 7 post-KTx plasma analyses showed approximately ten-fold lower TNF (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) in IFX versus PLBO. BK viremia requiring IS change occurred more frequently in IFX (28.9%) versus PLBO (13.4%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004), with a strong trend toward higher rates of BKV nephropathy in IFX (13.3%) versus PLBO (4.9%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IFX induction therapy does not benefit recipients of kidney transplants from deceased donors on this IS regimen. Because the intervention unexpectedly increased rates of BK virus infections, our findings underscore the complexities of targeting peritransplant inflammation as a strategy to improve KTx outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial registry name and registration number:<\/jats:bold>\n                      clinicaltrials.gov (NCT02495077).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.2022040454","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T15:30:25Z","timestamp":1664897425000},"page":"145-159","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial"],"prefix":"10.1681","volume":"34","author":[{"given":"Donald E.","family":"Hricik","sequence":"first","affiliation":[{"name":"Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Biostatistics, Rho, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-0817","authenticated-orcid":false,"given":"Tarek","family":"Alhamad","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphamai","family":"Bunnapradist","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-3381","authenticated-orcid":false,"given":"Sindhu","family":"Chandran","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert. L.","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute and the Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Foley","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6452-3976","authenticated-orcid":false,"given":"Richard","family":"Formica","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian W.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kesler","sequence":"additional","affiliation":[{"name":"Biostatistics, Rho, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-9831","authenticated-orcid":false,"given":"S. Joseph","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Health Network, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-3680","authenticated-orcid":false,"given":"Roslyn B.","family":"Mannon","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-4299","authenticated-orcid":false,"given":"Madhav C.","family":"Menon","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, Yale University, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Newell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nickerson","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah","family":"Odim","sequence":"additional","affiliation":[{"name":"Transplant Branch, Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio D.","family":"Poggio","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute and the Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Icahn School of Medicine at Mount Sinai and Recanati Miller Transplant Institute, Mount Sinai Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-2887","authenticated-orcid":false,"given":"Kathryn","family":"Tinckam","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Health Network, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Vincenti","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-6913","authenticated-orcid":false,"given":"Peter S.","family":"Heeger","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Icahn School of Medicine at Mount Sinai and Recanati Miller Transplant Institute, Mount Sinai Hospital, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"B1-20260114","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/ajt.16463","article-title":"Long-term kidney transplant graft survival\u2014Making progress when most needed","volume":"21","author":"Poggio","year":"2021","journal-title":"Am J Transplant"},{"key":"B2-20260114","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ki.2014.18","article-title":"Delayed kidney graft function: From mechanism to translation","volume":"86","author":"Schr\u00f6ppel","year":"2014","journal-title":"Kidney Int"},{"key":"B3-20260114","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-6143.2011.03754.x","article-title":"Delayed graft function in the kidney transplant","volume":"11","author":"Siedlecki","year":"2011","journal-title":"Am J Transplant"},{"key":"B4-20260114","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000491558","article-title":"Delayed graft function: The AKI of kidney transplantation","volume":"140","author":"Mannon","year":"2018","journal-title":"Nephron"},{"key":"B5-20260114","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/ndt\/gfn667","article-title":"Association between delayed graft function and allograft and patient survival: A systematic review and meta-analysis","volume":"24","author":"Yarlagadda","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"B6-20260114","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1600-6143.2005.00798.x","article-title":"A comparison of long-term graft survival rates between the first and second donor kidney transplanted\u2014The effect of a longer cold ischaemic time for the second kidney","volume":"5","author":"Giblin","year":"2005","journal-title":"Am J Transplant"},{"issue":"Suppl","key":"B7-20260114","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/TP.0b013e318169c29e","article-title":"Cold ischemia is a major determinant of acute rejection and renal graft survival in the modern era of immunosuppression","volume":"85","author":"Mikhalski","year":"2008","journal-title":"Transplantation"},{"key":"B8-20260114","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1523-1755.2004.00416.x","article-title":"Cold ischemia and the reduced long-term survival of cadaveric renal allografts","volume":"65","author":"Salahudeen","year":"2004","journal-title":"Kidney Int"},{"key":"B9-20260114","doi-asserted-by":"crossref","first-page":"E612","DOI":"10.1111\/j.1399-0012.2011.01510.x","article-title":"Influence of prolonged cold ischemia in renal transplantation","volume":"25","author":"van der Vliet","year":"2011","journal-title":"Clin Transplant"},{"key":"B10-20260114","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1097\/00007890-199812270-00022","article-title":"Deleterious effects of delayed graft function in cadaveric renal transplant recipients independent of acute rejection","volume":"66","author":"Shoskes","year":"1998","journal-title":"Transplantation"},{"key":"B11-20260114","first-page":"001","article-title":"The clinical and financial burden of early dialysis after deceased donor kidney transplantation","volume":"2012","author":"Buchanan","year":"2012","journal-title":"J Nephrol Ther"},{"key":"B12-20260114","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/00007890-199105000-00035","article-title":"The high cost of delayed graft function in cadaveric renal transplantation","volume":"51","author":"Rosenthal","year":"1991","journal-title":"Transplantation"},{"key":"B13-20260114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fimmu.2012.00341","article-title":"Which pathways trigger the role of complement in ischaemia\/reperfusion injury?","volume":"3","author":"Farrar","year":"2012","journal-title":"Front Immunol"},{"key":"B14-20260114","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1172\/JCI83000","article-title":"Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury","volume":"126","author":"Farrar","year":"2016","journal-title":"J Clin Invest"},{"key":"B15-20260114","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.coi.2007.07.007","article-title":"Graft-derived complement as a mediator of transplant injury","volume":"19","author":"Zhou","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"B16-20260114","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-6143.2010.03179.x","article-title":"A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation","volume":"10","author":"Irish","year":"2010","journal-title":"Am J Transplant"},{"key":"B17-20260114","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1006\/cyto.1998.0472","article-title":"Secretion of TNF-alpha, IL-8 and nitric oxide by macrophages activated with polyanions, and involvement of interferon-gamma in the regulation of cytokine secretion","volume":"11","author":"Sorimachi","year":"1999","journal-title":"Cytokine"},{"key":"B18-20260114","doi-asserted-by":"crossref","first-page":"e148643","DOI":"10.1172\/jci.insight.148643","article-title":"T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death","volume":"6","author":"Chun","year":"2021","journal-title":"JCI Insight"},{"key":"B19-20260114","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1097\/00003246-199910000-00019","article-title":"Human vascular endothelial cells produce tumor necrosis factor-alpha in response to proinflammatory cytokine stimulation","volume":"27","author":"Ranta","year":"1999","journal-title":"Crit Care Med"},{"key":"B20-20260114","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1073\/pnas.72.9.3666","article-title":"An endotoxin-induced serum factor that causes necrosis of tumors","volume":"72","author":"Carswell","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B21-20260114","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0140-6736(94)90628-9","article-title":"Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis","volume":"344","author":"Elliott","year":"1994","journal-title":"Lancet"},{"key":"B22-20260114","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0140-6736(94)90632-7","article-title":"Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis","volume":"344","author":"Elliott","year":"1994","journal-title":"Lancet"},{"key":"B23-20260114","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","article-title":"Maintenance infliximab for Crohn\u2019s disease: The ACCENT I randomised trial","volume":"359","author":"Hanauer","year":"2002","journal-title":"Lancet"},{"key":"B24-20260114","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1096\/fj.05-3841com","article-title":"TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury","volume":"19","author":"Al-Lamki","year":"2005","journal-title":"FASEB J"},{"key":"B25-20260114","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-6143.2009.02921.x","article-title":"Role of TNFalpha in early chemokine production and leukocyte infiltration into heart allografts","volume":"10","author":"Ishii","year":"2010","journal-title":"Am J Transplant"},{"key":"B26-20260114","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.cellsig.2005.03.020","article-title":"Synergistic activation of JNK\/SAPK induced by TNF-alpha and IFN-gamma: Apoptosis of pancreatic beta-cells via the p53 and ROS pathway","volume":"17","author":"Kim","year":"2005","journal-title":"Cell Signal"},{"key":"B27-20260114","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1111\/j.1600-6143.2011.03977.x","article-title":"Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes","volume":"12","author":"Bellin","year":"2012","journal-title":"Am J Transplant"},{"key":"B28-20260114","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrendo.2016.178","article-title":"Clinical pancreatic islet transplantation","volume":"13","author":"Shapiro","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"B29-20260114","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"B30-20260114","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1681\/ASN.2004060447","article-title":"Performance of the modification of diet in renal disease and Cockcroft\u2013Gault equations in the estimation of GFR in health and in chronic kidney disease","volume":"16","author":"Poggio","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"B31-20260114","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1056\/NEJMp2028243","article-title":"In search of a better equation\u2014Performance and equity in estimates of kidney function","volume":"384","author":"Diao","year":"2021","journal-title":"N Engl J Med"},{"key":"B32-20260114","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C-based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N Engl J Med"},{"key":"B33-20260114","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/ajt.12590","article-title":"Banff 2013 meeting report: Inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions","volume":"14","author":"Haas","year":"2014","journal-title":"Am J Transplant"},{"key":"B34-20260114","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1111\/ajt.14752","article-title":"Sensitization in transplantation: Assessment of risk (STAR) 2017 Working Group meeting report","volume":"18","author":"Tambur","year":"2018","journal-title":"Am J Transplant"},{"key":"B35-20260114","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/ndt\/gfu320","article-title":"Analysis of risk factors associated with renal function trajectory over time: A comparison of different statistical approaches","volume":"30","author":"Leffondre","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"B36-20260114","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/j.1399-3046.2010.01396.x","article-title":"Is calculating the standard deviation of tacrolimus blood levels the new gold standard for evaluating non-adherence to medications in transplant recipients?","volume":"14","author":"Shemesh","year":"2010","journal-title":"Pediatr Transplant"},{"key":"B37-20260114","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1600-6143.2011.03466.x","article-title":"Donor brain death predisposes human kidney grafts to a proinflammatory reaction after transplantation","volume":"11","author":"de Vries","year":"2011","journal-title":"Am J Transplant"},{"key":"B38-20260114","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0041-1345(00)02479-9","article-title":"Influence of brain death on cytokine release in organ donors and renal transplants","volume":"33","author":"Stangl","year":"2001","journal-title":"Transplant Proc"},{"key":"B39-20260114","doi-asserted-by":"crossref","first-page":"e052138","DOI":"10.1136\/bmjopen-2021-052138","article-title":"Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: Proof-of-concept study","volume":"11","author":"Aubert","year":"2021","journal-title":"BMJ Open"},{"key":"B40-20260114","doi-asserted-by":"crossref","first-page":"l4923","DOI":"10.1136\/bmj.l4923","article-title":"Prediction system for risk of allograft loss in patients receiving kidney transplants: International derivation and validation study","volume":"366","author":"Loupy","year":"2019","journal-title":"BMJ"},{"key":"B41-20260114","doi-asserted-by":"crossref","first-page":"e0169624","DOI":"10.1371\/journal.pone.0169624","article-title":"Sequential targeting of CD52 and TNF allows early minimization therapy in kidney transplantation: From a biomarker to targeting in a proof-of-concept trial","volume":"12","author":"Viklicky","year":"2017","journal-title":"PLoS One"},{"key":"B42-20260114","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cct.2017.05.013","article-title":"The effect of the use of a TNF-alpha inhibitor in hypothermic machine perfusion on kidney function after transplantation","volume":"59","author":"Diuwe","year":"2017","journal-title":"Contemp Clin Trials"},{"key":"B43-20260114","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1111\/ajt.14961","article-title":"Improved outcomes of islet autotransplant after total pancreatectomy by combined blockade of IL-1\u03b2 and TNF\u03b1","volume":"18","author":"Naziruddin","year":"2018","journal-title":"Am J Transplant"},{"key":"B44-20260114","doi-asserted-by":"crossref","first-page":"e557","DOI":"10.1097\/TXD.0000000000001000","article-title":"BK viremia exacerbation with adalimumab coadministration","volume":"6","author":"Lum","year":"2020","journal-title":"Transplant Direct"},{"key":"B45-20260114","doi-asserted-by":"crossref","first-page":"970528","DOI":"10.1155\/2014\/970528","article-title":"Prospective study of BK virus infection in patients with inflammatory bowel disease","volume":"2014","author":"Flores","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"B46-20260114","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1159\/000448077","article-title":"TNF\u03b1 augments cytokine-induced NK cell IFN\u03b3 production through TNFR2","volume":"8","author":"Almishri","year":"2016","journal-title":"J Innate Immun"},{"key":"B47-20260114","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ki.2013.148","article-title":"Natural killer cell response to BK virus infection in polyoma virus-associated nephropathy of renal transplant recipients","volume":"84","author":"Acott","year":"2013","journal-title":"Kidney Int"},{"key":"B48-20260114","doi-asserted-by":"crossref","first-page":"e1000924","DOI":"10.1371\/journal.ppat.1000924","article-title":"NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors","volume":"6","author":"Mishra","year":"2010","journal-title":"PLoS Pathog"},{"key":"B49-20260114","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1189\/jlb.0611308","article-title":"Natural killer cell-produced IFN-\u03b3 and TNF-\u03b1 induce target cell cytolysis through up-regulation of ICAM-1","volume":"91","author":"Wang","year":"2012","journal-title":"J Leukoc Biol"},{"key":"B50-20260114","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12882-021-02645-y","article-title":"The effect of BKV reactivation on cytokines behavior in kidney transplanted patients","volume":"23","author":"Rahimi","year":"2022","journal-title":"BMC Nephrol"},{"key":"B51-20260114","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11010-015-2581-1","article-title":"BK virus infection activates the TNF\u03b1\/TNF receptor system in polyomavirus-associated nephropathy","volume":"411","author":"Ribeiro","year":"2016","journal-title":"Mol Cell Biochem"}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2022040454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:24:02Z","timestamp":1786130642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1681\/ASN.2022040454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,4]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.2022040454","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,4]]},"assertion":[{"value":"2022-04-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}