{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:06:40Z","timestamp":1786133200688,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      This study reports for the first time a relationship between dietary Mg and the renal thiazide-sensitive Na-Cl cotransporter (TZR, measured by saturation binding with\n                      <jats:sup>3<\/jats:sup>\n                      H-metolazone). Ion-selective electrodes measured plasma ionized magnesium (P\n                      <jats:sub>Mg<\/jats:sub>\n                      + +), calcium (P\n                      <jats:sub>Ca<\/jats:sub>\n                      + +), and potassium (P\n                      <jats:sub>K<\/jats:sub>\n                      +). Restricting dietary Mg for 1 wk decreased P\n                      <jats:sub>Mg<\/jats:sub>\n                      + + 18%, TZR 25%, and renal excretion of magnesium (U\n                      <jats:sub>Mg<\/jats:sub>\n                      ) and calcium (U\n                      <jats:sub>Ca<\/jats:sub>\n                      ) more than 50% without changing P\n                      <jats:sub>Ca<\/jats:sub>\n                      + +, P\n                      <jats:sub>K<\/jats:sub>\n                      +, or plasma aldosterone. A low Mg diet for 1 d significantly decreased P\n                      <jats:sub>Mg<\/jats:sub>\n                      + +, TZR, U\n                      <jats:sub>Mg<\/jats:sub>\n                      and U\n                      <jats:sub>Ca<\/jats:sub>\n                      . Return of dietary Mg after 5 d of Mg restriction restored P\n                      <jats:sub>Mg<\/jats:sub>\n                      + + and TZR toward normal. In the control, Mg-deficient, and Mg-repleting animals, TZR correlated with P\n                      <jats:sub>Mg<\/jats:sub>\n                      + + (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.86) and with U\n                      <jats:sub>Mg<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.87) but not U\n                      <jats:sub>Ca<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.09). Increasing oral intake of Mg for 1 wk increased P\n                      <jats:sub>Mg<\/jats:sub>\n                      + + 14%, TZR 32%, U\n                      <jats:sub>Mg<\/jats:sub>\n                      74%, and U\n                      <jats:sub>Ca<\/jats:sub>\n                      more than fourfold without changing P\n                      <jats:sub>Ca<\/jats:sub>\n                      + + or P\n                      <jats:sub>K<\/jats:sub>\n                      +. In contrast, increasing dietary Ca content from 0.02% to 1.91% did not change TZR, but increased U\n                      <jats:sub>Ca<\/jats:sub>\n                      fivefold without changing P\n                      <jats:sub>Ca<\/jats:sub>\n                      + +. Hormonal mediators (if any) involved in the relationship between dietary Mg and TZR remain to be elucidated, as does the relationship between TZR and tubular reabsorption of Mg.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v103458","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T04:54:35Z","timestamp":1619585675000},"page":"458-463","source":"Crossref","is-referenced-by-count":7,"title":["Dietary Magnesium, Not Calcium, Regulates Renal Thiazide Receptor"],"prefix":"10.1681","volume":"10","author":[{"given":"DARRELL D.","family":"FANESTIL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RONALD H.","family":"HYDE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICIA","family":"BLAKELY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DUKE A.","family":"VAUGHN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-199903000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:30:11Z","timestamp":1786131011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-199903000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v103458","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}