{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:23:44Z","timestamp":1790630624473,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      Hypertension after renal transplantation occurs commonly and, in adults, is associated with decreased graft survival. The North American Pediatric Renal Transplant Cooperative Study database was analyzed to determine: (\n                      <jats:italic toggle=\"yes\">1<\/jats:italic>\n                      ) the percent use of antihypertensive (anti-HTN) medication based on donor type, race, age, and acute rejection status; and (\n                      <jats:italic toggle=\"yes\">2<\/jats:italic>\n                      ) whether use of anti-HTN medication is associated with higher rates of subsequent graft failure. Data regarding anti-HTN medication use was available in 5251 renal allografts (4821 patients) with &gt;30 d graft function. Posttransplant follow-up data were collected at 30 d, 6 mo, 12 mo, and then annually for 5 yr. At each follow-up, patients were selected for further analysis if the graft was functioning at that visit and subsequent follow-up data were available. Overall, anti-HTN medication use was 79% on day 30 and 58% at 5 yr. At each follow-up, anti-HTN medication use was higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) for cadaveric donor\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      living related donor, blacks\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      whites, age &gt;12\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      &lt;12 yr, and \u22651\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      0 acute rejection episodes. Anti-HTN medication use at each annual follow-up was associated with significantly higher rates of subsequent graft failure. Multiple regression analysis controlling for all factors associated with increased use of anti-HTN medications revealed a relative risk of graft failure for use of anti-HTN medication of greater than 1.4 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In recipients of cadaveric allografts, only acute rejection status predicted subsequent graft failure more strongly than use of anti-HTN medications. These data suggest that hypertension after renal transplantation in children, as evidenced by use of anti-HTN medications, is associated with increased rates of subsequent graft failure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v1061324","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T15:52:20Z","timestamp":1620143540000},"page":"1324-1330","source":"Crossref","is-referenced-by-count":87,"title":["Antihypertensive Medication and Renal Allograft Failure"],"prefix":"10.1681","volume":"10","author":[{"given":"JONATHAN M.","family":"SOROF","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. KENNETH","family":"SULLIVAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AMIR","family":"TEJANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RONALD J.","family":"PORTMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-199906000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:24:05Z","timestamp":1786130645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-199906000-00020"}},"subtitle":["A North American Pediatric Renal Transplant Cooperative Study Report"],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v1061324","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}