{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:01:27Z","timestamp":1791334887331,"version":"4.3.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      To evaluate a possible effect of peritoneal transport properties and dialysis dose on the physical development of children on chronic peritoneal dialysis, a cohort of 51 children was prospectively followed for 18 mo. Peritoneal transport characteristics were assessed by serial peritoneal equilibration tests (PET), dialysis efficacy by dialysate and residual renal clearance measurements, and growth and nutritional status by the longitudinal changes (\u0394) of height SD score (SDS), body mass index (BMI) SDS, and serum albumin. \u0394 height SDS was negatively correlated with the creatinine equilibration rate observed in the initial PET (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = -0.31,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Multiple regression analysis confirmed the negative effect of the high transporter state (partial\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.07), and disclosed an additional positive effect of dialytic C\n                      <jats:sub>Cr<\/jats:sub>\n                      (partial\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.11) and a weak negative effect of daily dialysate volume (partial\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.04) on \u0394 height SDS. \u0394 BMI SDS was strongly age-dependent (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = -0.48,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001); while relative body mass gradually increased below 4 yr of age, it remained stable in older children. Positive changes in BMI SDS were associated with rapid PET creatinine equilibration rates (univariate\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.35,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and\/or large dialysate volumes (multivariate partial\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.11), suggesting a role of dialytic glucose uptake in the development of obesity. The change in serum albumin concentrations was positively correlated with dialysate volume (partial\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.14), and negatively affected by dialytic protein losses (partial\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.06). In conclusion, the peritoneal transporter state is a weak but significant determinant of growth and body mass gain in children on chronic peritoneal dialysis. Rapid small solute equilibration contributes to impaired growth but enhanced acquisition of body mass. Dialytic small solute clearance has a weak positive effect on statural growth independent of the transporter state, but does not affect body mass gain.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v1081786","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T14:18:19Z","timestamp":1619619499000},"page":"1786-1792","source":"Crossref","is-referenced-by-count":104,"title":["Peritoneal Transport Properties and Dialysis Dose Affect Growth and Nutritional Status in Children on Chronic Peritoneal Dialysis"],"prefix":"10.1681","volume":"10","author":[{"given":"FRANZ","family":"SCHAEFER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00dcNTER","family":"KLAUS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OTTO","family":"MEHLS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-199908000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:26:07Z","timestamp":1786130767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-199908000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v1081786","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}