{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:19:03Z","timestamp":1789370343940,"version":"build-2803163510"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      This study examined the hypothesis that nocturnal enuresis might be paralleled by aquaporin 2 (AQP2) urinary excretion. Eighty children who experienced nocturnal enuresis were studied and compared with 9 healthy children. The 24-h urine samples were divided into two portions: night collections and day collections. Creatinine equivalents of urine samples from each patient were analyzed by Western blotting. AQP2 levels were semiquantified by densitometric scanning and reported as a ratio between the intensity of the signal in the day urine sample\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      the night urine sample (D\/N AQP2 ratio). The D\/N AQP2 ratio was 0.59 \u00b1 0.11 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 9) in healthy children and increased to 1.27 \u00b1 0.24 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10) in a subpopulation of enuretic children who had low nocturnal vasopressin levels. In enuretic children who displayed hypercalciuria and had normal vasopressin levels, the D\/N AQP2 ratio was 1.05 \u00b1 0.27 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8). These data indicate that reduced secretion of vasopressin and absorptive hypercalciuria are independently associated with an approximately twofold increase in the urinary D\/N AQP2 ratio. When low nocturnal vasopressin levels were associated with hypercalciuria, a nearly threefold increase in the D\/N AQP2 ratio was observed (1.67 \u00b1 0.41,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 11). In addition, in all enuretic patients tested, the urinary D\/N AQP2 ratio correlates perfectly with the severity of the disorder (nocturnal polyuria). The findings reported in this article indicate that urinary AQP2 correlates with the severity of enuresis in children.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v11101873","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T14:04:00Z","timestamp":1619618640000},"page":"1873-1881","source":"Crossref","is-referenced-by-count":86,"title":["Urinary Aquaporin 2 and Calciuria Correlate with the Severity of Enuresis in Children"],"prefix":"10.1681","volume":"11","author":[{"given":"GIOVANNA","family":"VALENTI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANTONIA","family":"LAERA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIUSEPPE","family":"PACE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GABRIELLA","family":"ACETO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA L.","family":"LOSPALLUTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSA","family":"PENZA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCESCO P.","family":"SELVAGGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA L.","family":"CHIOZZA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA","family":"SVELTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200010000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:29:29Z","timestamp":1786130969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200010000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v11101873","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}