{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:05:04Z","timestamp":1786133104572,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      The genetic basis and cellular defects of a number of primary magnesium wasting diseases have been elucidated over the past decade. This review correlates the clinical pathophysiology with the primary defect and secondary changes in cellular electrolyte transport. The described disorders include (\n                      <jats:italic toggle=\"yes\">1<\/jats:italic>\n                      ) hypomagnesemia with secondary hypocalcemia, an earlyonset, autosomal-recessive disease segregating with chromosome 9q12-22.2; (\n                      <jats:italic toggle=\"yes\">2<\/jats:italic>\n                      ) autosomal-dominant hypomagnesemia caused by isolated renal magnesium wasting, mapped to chromosome 11q23; (\n                      <jats:italic toggle=\"yes\">3<\/jats:italic>\n                      ) hypomagnesemia with hypercalciuria and nephrocalcinosis, a recessive condition caused by a mutation of the claudin 16 gene (3q27) coding for a tight junctional protein that regulates paracellular Mg\n                      <jats:sup>2+<\/jats:sup>\n                      transport in the loop of Henle; (\n                      <jats:italic toggle=\"yes\">4<\/jats:italic>\n                      ) autosomal-dominant hypoparathyroidism, a variably hypomagnesemic disorder caused by inactivating mutations of the extracellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \/Mg\n                      <jats:sup>2+<\/jats:sup>\n                      -sensing receptor,\n                      <jats:italic toggle=\"yes\">Casr<\/jats:italic>\n                      gene, at 3q13.3-21 (a significant association between common polymorphisms of the\n                      <jats:italic toggle=\"yes\">Casr<\/jats:italic>\n                      and extracellular Mg\n                      <jats:sup>2+<\/jats:sup>\n                      concentration has been demonstrated in a healthy adult population); and (\n                      <jats:italic toggle=\"yes\">5<\/jats:italic>\n                      ) Gitelman syndrome, a recessive form of hypomagnesemia caused by mutations in the distal tubular NaCl cotransporter gene,\n                      <jats:italic toggle=\"yes\">SLC12A3<\/jats:italic>\n                      , at 16q13. The basis for renal magnesium wasting in this disease is not known. These inherited conditions affect different nephron segments and different cell types and lead to variable but increasingly distinguishable phenotypic presentations. No doubt, there are in the general population other disorders that have not yet been identified or characterized. The continued use of molecular techniques to probe the constitutive and congenital disturbances of magnesium metabolism will increase the understanding of cellular magnesium transport and provide new insights into the way these diseases are diagnosed and managed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v11101937","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T14:04:00Z","timestamp":1619618640000},"page":"1937-1947","source":"Crossref","is-referenced-by-count":111,"title":["Inherited Disorders of Renal Magnesium Handling"],"prefix":"10.1681","volume":"11","author":[{"given":"DAVID E. C.","family":"COLE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GARY A.","family":"QUAMME","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200010000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:28:44Z","timestamp":1786130924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200010000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v11101937","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}