{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:43:14Z","timestamp":1791268994665,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      The function of renal transplants can deteriorate at any time posttransplant, but the risks and mechanisms may differ at different times posttransplant. Survival of 522 consecutive cadaveric renal transplant recipients followed for at least 6 mo were analyzed, with patient death censored. The overall risk factors in univariate analysis were acute rejection requiring antibody therapy (AR), delayed graft function, elevated serum creatinine at 6 mo, high panel-reactive antibodies, and donor age \u226555 yr, with borderline effects of recipient age and female gender. These risks were studied in each of three intervals posttransplantation: \u22646 mo, 6 mo to 5 yr, and &gt;5 yr. Of the 135 graft failures, 53 occurred \u22646 mo, 61 between 6 mo and 5 yr, and 21 beyond 5 yr. By multivariate analysis, the risks for graft failure in interval \u22646 mo were AR (hazard ratio (HR) = 4.86,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001); delayed graft function (HR = 1.47,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.06); and high panel-reactive antibodies (HR = 2.04,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). Between 6 mo and 5 yr, the risks for graft loss were AR (HR = 2.87,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and serum creatinine at 6 mo \u2265150 \u03bcmol\/L (HR = 3.69,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Beyond 5 yr the risk factors were donor age \u226555 yr (HR = 5.87,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), with a borderline effect of kidneys from female donors (HR = 2.28,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.07). HLA-A, -B, and -DR matching and presensitization had most of their effect through early AR and impaired function. The results indicate that risks for graft loss are time-dependent: early losses correlate with injury and rejection, but late events correlate with donor age and possibly workload.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v113565","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T13:28:43Z","timestamp":1619616523000},"page":"565-573","source":"Crossref","is-referenced-by-count":144,"title":["Time Dependency of Factors Affecting Renal Allograft Survival"],"prefix":"10.1681","volume":"11","author":[{"given":"SURAZEE","family":"PROMMOOL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIAN S.","family":"JHANGRI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SANDRA M.","family":"COCKFIELD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIP F.","family":"HALLORAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200003000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:25:43Z","timestamp":1786130743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200003000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v113565","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}