{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:03:44Z","timestamp":1786133024405,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      Cell adhesion through different adhesion molecules is a crucial event in the inflammatory response. Integrins can only bind and mediate cellular adhesion after their activation by different specific stimuli. The state of \u03b21 integrin activation can be assessed by a group of monoclonal antibodies (HUTS) that selectively recognize \u03b21 integrins in their active form. A similar activated epitope in the rat was defined using the anti-human monoclonal antibody HUTS-21, which recognizes an activation-dependent epitope on the \u03b21 chain. It was found that the divalent cations Mn\n                      <jats:sup>2+<\/jats:sup>\n                      and Hg\n                      <jats:sup>2+<\/jats:sup>\n                      were able to induce\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      the activation of \u03b21 integrins on rat lymphocytes. The Hg\n                      <jats:sup>2+<\/jats:sup>\n                      cation induces an autoimmune disease in the Brown Norway rat characterized by synthesis and glomerular deposits of anti-glomerular basement membrane antibodies, proteinuria, and interstitial nephritis. Using the mercury model of nephritis, it was found that the expression of HUTS-21 epitope is induced\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      in rat lymphocytes, and its appearance is correlated with the other parameters at the onset of the disease. In addition, the administration of HUTS-21 monoclonal antibody to HgCl\n                      <jats:sub>2<\/jats:sub>\n                      -treated rats offered evidence of its protective effects (\n                      <jats:italic toggle=\"yes\">1<\/jats:italic>\n                      ) against infiltration of renal interstitium by leukocytes, and (\n                      <jats:italic toggle=\"yes\">2<\/jats:italic>\n                      ) in the reduction of anti-glomerular basement membrane synthesis and glomerular deposition. Nevertheless, urinary protein values remained unaffected. These results demonstrate a key role of \u03b21-activated integrins in both leukocyte cell-cell interactions and leukocyte infiltration pathway mechanism, and also indicate that leukocyte migration may have less importance in the development of this disease than previously thought.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v1161075","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T10:50:56Z","timestamp":1619347856000},"page":"1075-1084","source":"Crossref","is-referenced-by-count":8,"title":["Functional Relevance of Activated \u03b21 Integrins in Mercury-Induced Nephritis"],"prefix":"10.1681","volume":"11","author":[{"given":"ESTHER","family":"ESCUDERO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANA","family":"MART\u00cdN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTA","family":"NIETO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELENA","family":"NIETO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELENA","family":"NAVARRO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALFONSO","family":"LUQUE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARLOS","family":"CABAN[Combining Tilde]AS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCISCO","family":"S\u00c1NCHEZ-MADRID","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCISCO","family":"MAMPASO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200006000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:27:33Z","timestamp":1786130853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200006000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v1161075","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}