{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:01:58Z","timestamp":1786132918628,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>\n                      Kidneys from mice, dogs, and humans with X-linked and autosomal-recessive forms of Alport syndrome were examined by immunofluorescence for expression of laminin \u03b1, \u03b2, and \u03b3 chains using monospecific antibodies. Laminin \u03b12 chain was absent from glomerular basement membranes (GBM) in normal human, murine, and canine kidneys but was abnormally deposited in Alport GBM, regardless of species or inheritance pattern. In murine and canine Alport kidneys, laminin \u03b12 seems to be deposited as part of both laminin-2 (\u03b12\u03b21\u03b31) and laminin-4 (\u03b12\u03b22\u03b31) but as part of only laminin-4 in human Alport kidneys. GBM laminin \u03b12 chain deposition was not observed in a variety of non-Alport human glomerulopathies. This finding adds to the list of proteins that are aberrantly deposited in Alport GBM as a consequence of the absence of the \u03b13, \u03b14, and \u03b15 chains of type IV collagen: (\n                      <jats:italic toggle=\"yes\">1<\/jats:italic>\n                      ) type IV collagen \u03b11 and \u03b12 chains, (\n                      <jats:italic toggle=\"yes\">2<\/jats:italic>\n                      ) type V collagen, (\n                      <jats:italic toggle=\"yes\">3<\/jats:italic>\n                      ) type VI collagen, and most recently (\n                      <jats:italic toggle=\"yes\">4<\/jats:italic>\n                      ) the laminin \u03b12 chain and (\n                      <jats:italic toggle=\"yes\">5<\/jats:italic>\n                      ) the laminin \u03b11 and \u03b21 chains in mice and dogs. These findings emphasize further the critical role played by the \u03b13, \u03b14, and \u03b15 chains of type IV collagen in establishing and maintaining the composition, structure, and function of mature GBM.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v122252","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:07:29Z","timestamp":1619442449000},"page":"252-260","source":"Crossref","is-referenced-by-count":80,"title":["Abnormal Glomerular Basement Membrane Laminins in Murine, Canine, and Human Alport Syndrome"],"prefix":"10.1681","volume":"12","author":[{"given":"CLIFFORD E.","family":"KASHTAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOUNGKI","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEORGE E.","family":"LEES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL S.","family":"THORNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISMO","family":"VIRTANEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEFFREY H.","family":"MINER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200102000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:26:01Z","timestamp":1786130761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200102000-00006"}},"subtitle":["Aberrant Laminin \u03b12 Deposition Is Species Independent"],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v122252","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}