{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:36:11Z","timestamp":1791408971776,"version":"4.3.3"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract.<\/jats:title>\n                    <jats:p>Minimal-change nephrotic syndrome (MCNS) is a renal disease characterized by heavy glomerular proteinuria and increased production of cytokines by immune cells. Because of the central role of nuclear factor-\u03baB (NF-\u03baB) in the regulation of cytokine expression, its activity during the relapse and remission phases of steroid-sensitive MCNS was analyzed. During relapse, nuclear extracts from peripheral blood mononuclear cells displayed high levels of NF-\u03baB DNA-binding activity, consisting primarily of p50\/RelA (p65) complexes. NF-\u03baB p65 and I\u03baB\u03b1 proteins were barely detected or not detected in cytosolic fractions during relapse, in contrast to remission. The lack of expression of I\u03baB\u03b1 protein was associated with downregulation of I\u03baB\u03b1 mRNA and increases in the levels of the mRNA encoding the proteasome \u03b12 subunit proteolytic pathway. In addition, inhibition of proteasome activity induced cytosolic accumulation of phosphorylated I\u03baB\u03b1 and significant reductions in the NF-\u03baB binding activity in nuclear extracts from peripheral blood mononuclear cells from patients experiencing relapses. These results suggest that alterations in the NF-\u03baB\/I\u03baB\u03b1 regulatory feedback loop may contribute to the immunologic abnormalities that occur in steroidsensitive MCNS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1681\/asn.v1281648","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T20:51:11Z","timestamp":1619470271000},"page":"1648-1658","source":"Crossref","is-referenced-by-count":65,"title":["Transcriptional and Post-Transcriptional Alterations of I \u03baB\u03b1 in Active Minimal-Change Nephrotic Syndrome"],"prefix":"10.1681","volume":"12","author":[{"given":"DJILLALI","family":"SAHALI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDR\u00c9","family":"PAWLAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SABINE LE","family":"GOUVELLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPE","family":"LANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ASTA","family":"VALANCIUT\u00c9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPE","family":"REMY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHANTAL","family":"LOIRAT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICK","family":"NIAUDET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALBERT","family":"BENSMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEORGES","family":"GUELLAEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001751-200108000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:33:58Z","timestamp":1786131238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001751-200108000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.v1281648","relation":{},"ISSN":["1046-6673"],"issn-type":[{"value":"1046-6673","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}