{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:49:58Z","timestamp":1772819398104,"version":"3.50.1"},"reference-count":75,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","funder":[{"name":"European Research Council","award":["101097830"],"award-info":[{"award-number":["101097830"]}]},{"DOI":"10.13039\/501100014717","name":"Programa Operacional Regional do Centro","doi-asserted-by":"crossref","award":["CENTRO-01-02B7-FEDER-069917"],"award-info":[{"award-number":["CENTRO-01-02B7-FEDER-069917"]}],"id":[{"id":"10.13039\/501100014717","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JASN"],"published-print":{"date-parts":[[2025,11]]},"abstract":"\n Key Points<\/jats:title>\n \n \n \n \n Engineered Neuromedin U (LIMM102) had augmented efficacy in activating renal type 2 innate lymphoid cells (ILC2) both\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n LIMM102 reduced mortality and enhanced kidney function in a model of AKI by activating renal ILC2s.<\/jats:p>\n <\/jats:list-item>\n \n The renoprotective effects of LIMM102 were neuromedin U receptor 1\u2013dependent, highlighting the ILC2-neuromedin U receptor 1 axis as a novel therapeutic target for AKI therapy.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n AKI is a severe condition leading to the sudden loss of kidney function. Activation of type 2 innate lymphoid cells (ILC2s) by neuromedin U (NMU) is highly selective and key in controlling mucosal tissue repair and homeostasis. Renal ILC2s are associated with renoprotective effects in AKI. Here, we explored the therapeutic potential of an engineered NMU analogue (LIMM102) in a preclinical model of renal ischemia-reperfusion injury (IRI)\u2013induced AKI.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n LIMM102 was administered prophylactically to wild-type mice subjected to IRI-induced AKI and to Sham-operated controls. Survival, GFR, kidney function biomarkers, histopathologic analysis, and immune cell infiltration were assessed to determine LIMM102 treatment efficacy. Moreover, to interrogate the molecular selectivity of LIMM102, NMU receptor 1 (NMUR1)\u2013deficient mice (\n Nmur1<\/jats:italic>\n \u2212\/\u2212<\/jats:sup>\n ) were used to formally test the need of NMUR1 signaling for the beneficial effects of LIMM102.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n LIMM102-treated IRI animals presented lower mortality rates when compared with their untreated IRI counterparts. Notably, LIMM102-treated animals displayed higher GFR, lower levels of kidney function biomarkers, and lower severity of kidney lesions, which associated with renal ILC2-activated phenotypes. Importantly, LIMM102 therapeutic effects relied entirely on NMUR1 signaling, as LIMM102 administration produced no beneficial effect on AKI outcome in\n Nmur1<\/jats:italic>\n -deficient animals.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n LIMM102 exerted its therapeutic action by improving kidney function in IRI-induced AKI\n via<\/jats:italic>\n NMUR1, which was associated with the presence of activated ILC2s in the kidney.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1681\/asn.0000000747","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T12:10:13Z","timestamp":1746706213000},"page":"2120-2130","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Engineered Neuromedin U Promotes Type 2 Innate Immunity and Renoprotection in Acute Kidney Injury"],"prefix":"10.1681","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-2109","authenticated-orcid":false,"given":"Sara","family":"Trindade-Correia","sequence":"first","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"},{"name":"Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Champalimaud Research, Champalimaud Foundation Centre For The Unknown, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-5527","authenticated-orcid":false,"given":"Vasco","family":"Correia","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9964-4612","authenticated-orcid":false,"given":"Filipe","family":"Delgado","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"given":"Marta","family":"Baptista","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-7435","authenticated-orcid":false,"given":"In\u00eas Amendoeira","family":"Cabral","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5283-5013","authenticated-orcid":false,"given":"T\u00e2nia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Champalimaud Research, Champalimaud Foundation Centre For The Unknown, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1289-4994","authenticated-orcid":false,"given":"Luana","family":"Macedo","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"given":"Margarida","family":"Nunes","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"given":"Pedro Z.","family":"Andrade","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-5093","authenticated-orcid":false,"given":"Filipa","family":"Cardoso","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"given":"Julie","family":"Chesn\u00e9","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"given":"David F.","family":"Braga Malta","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7011-131X","authenticated-orcid":false,"given":"Covadonga","family":"Pa\u00f1eda","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-1836","authenticated-orcid":false,"given":"Henrique","family":"Veiga-Fernandes","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"},{"name":"Champalimaud Research, Champalimaud Foundation Centre For The Unknown, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2330-7553","authenticated-orcid":false,"given":"V\u00e2nia","family":"Cardoso","sequence":"additional","affiliation":[{"name":"LiMM Therapeutics, Lisboa, Portugal"},{"name":"Collaborative Laboratory to Foster Translation and Drug Discovery, AccelBio, Cantanhede, Portugal"}]}],"member":"276","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"issue":"1","key":"B1-20251226","first-page":"19","article-title":"Acute kidney injury","volume":"7","author":"Patschan","year":"2015","journal-title":"J Inj Violence Res."},{"issue":"1","key":"B2-20251226","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat Rev Dis Primers."},{"issue":"10212","key":"B3-20251226","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet."},{"issue":"11","key":"B4-20251226","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest."},{"issue":"5","key":"B5-20251226","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat Rev Nephrol."},{"issue":"11","key":"B6-20251226","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2014from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat Med."},{"issue":"3","key":"B7-20251226","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1681\/ASN.2017070774","article-title":"Potentiating tissue-resident type 2 innate lymphoid cells by IL-33 to prevent renal ischemia-reperfusion injury","volume":"29","author":"Cao","year":"2018","journal-title":"J Am Soc Nephrol."},{"issue":"9","key":"B8-20251226","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1681\/ASN.2014050479","article-title":"IL-25 elicits innate lymphoid cells and multipotent progenitor type 2 cells that reduce renal ischemic\/reperfusion injury","volume":"26","author":"Huang","year":"2015","journal-title":"J Am Soc Nephrol."},{"issue":"7","key":"B9-20251226","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1681\/ASN.2016080877","article-title":"IL-33-Mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis","volume":"28","author":"Riedel","year":"2017","journal-title":"J Am Soc Nephrol."},{"key":"B10-20251226","doi-asserted-by":"crossref","first-page":"155963","DOI":"10.1016\/j.cyto.2022.155963","article-title":"IL-33 attenuates renal fibrosis via group2 innate lymphoid cells","volume":"157","author":"Nagashima","year":"2022","journal-title":"Cytokine."},{"issue":"9","key":"B11-20251226","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1681\/ASN.2016121272","article-title":"IL233, A novel IL-2 and IL-33 hybrid cytokine, ameliorates renal injury","volume":"28","author":"Stremska","year":"2017","journal-title":"J Am Soc Nephrol."},{"issue":"1","key":"B12-20251226","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4049\/jimmunol.1901095","article-title":"Expansion of group 2 innate lymphoid cells in patients with end-stage renal disease and their clinical significance","volume":"205","author":"Liu","year":"2020","journal-title":"J Immunol."},{"issue":"7671","key":"B13-20251226","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature23469","article-title":"Neuronal regulation of type 2 innate lymphoid cells via neuromedin U","volume":"549","author":"Cardoso","year":"2017","journal-title":"Nature."},{"issue":"7671","key":"B14-20251226","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature23676","article-title":"The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation","volume":"549","author":"Klose","year":"2017","journal-title":"Nature."},{"issue":"7672","key":"B15-20251226","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature24029","article-title":"The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation","volume":"549","author":"Wallrapp","year":"2017","journal-title":"Nature."},{"issue":"7876","key":"B16-20251226","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-021-03830-7","article-title":"Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit","volume":"597","author":"Cardoso","year":"2021","journal-title":"Nature."},{"issue":"7470","key":"B17-20251226","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"Nussbaum","year":"2013","journal-title":"Nature."},{"key":"B18-20251226","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejphar.2017.06.031","article-title":"Interleukin-33 signaling contributes to renal fibrosis following ischemia reperfusion","volume":"812","author":"Liang","year":"2017","journal-title":"Eur J Pharmacol."},{"issue":"7","key":"B19-20251226","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.4049\/jimmunol.181.7.4780","article-title":"IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4","volume":"181","author":"Kurowska-Stolarska","year":"2008","journal-title":"J Immunol."},{"issue":"1","key":"B20-20251226","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jaci.2012.02.013","article-title":"A critical role of IL-33 in experimental allergic rhinitis","volume":"130","author":"Haenuki","year":"2012","journal-title":"J Allergy Clin Immunol."},{"issue":"5","key":"B21-20251226","first-page":"897","article-title":"Soluble ST2 is increased in systemic lupus erythematous and is a potential marker of lupus nephritis","volume":"40","author":"Moreau","year":"2022","journal-title":"Clin Exp Rheumatol."},{"issue":"20","key":"B22-20251226","doi-asserted-by":"crossref","first-page":"32407","DOI":"10.18632\/oncotarget.16299","article-title":"IL-33\/ST2-mediated inflammation in macrophages is directly abrogated by IL-10 during rheumatoid arthritis","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget."},{"issue":"9","key":"B23-20251226","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1039\/c3mb70147f","article-title":"Extolling the benefits of molecular therapeutic lipidation","volume":"9","author":"Avadisian","year":"2013","journal-title":"Mol Biosyst."},{"key":"B24-20251226","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ejmech.2015.07.020","article-title":"Small lipidated anti-obesity compounds derived from neuromedin U","volume":"101","author":"Micewicz","year":"2015","journal-title":"Eur J Med Chem."},{"issue":"24","key":"B25-20251226","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1021\/jm070861j","article-title":"Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness","volume":"50","author":"Madsen","year":"2007","journal-title":"J Med Chem."},{"issue":"140","key":"B26-20251226","first-page":"e58520","article-title":"Transdermal measurement of glomerular filtration rate in mice","author":"Scarfe","year":"2018","journal-title":"J Vis Exp."},{"issue":"5","key":"B27-20251226","doi-asserted-by":"crossref","first-page":"F783","DOI":"10.1152\/ajprenal.00279.2012","article-title":"Transcutaneous measurement of renal function in conscious mice","volume":"303","author":"Schreiber","year":"2012","journal-title":"Am J Physiol Renal Physiol."},{"issue":"3","key":"B28-20251226","doi-asserted-by":"crossref","first-page":"F565","DOI":"10.1152\/ajprenal.00023.2003","article-title":"Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury","volume":"285","author":"Okusa","year":"2003","journal-title":"Am J Physiol Renal Physiol."},{"issue":"5","key":"B29-20251226","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1093\/ndt\/gfp659","article-title":"N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins","volume":"25","author":"Kim","year":"2010","journal-title":"Nephrol Dial Transplant."},{"issue":"4","key":"B30-20251226","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"issue":"2","key":"B31-20251226","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1124\/pr.56.2.3","article-title":"Neuromedin U and its receptors: structure, function, and physiological roles","volume":"56","author":"Brighton","year":"2004","journal-title":"Pharmacol Rev."},{"key":"B32-20251226","doi-asserted-by":"crossref","first-page":"671966","DOI":"10.3389\/fimmu.2021.671966","article-title":"The fate of activated group 2 innate lymphoid cells","volume":"12","author":"Math\u00e4","year":"2021","journal-title":"Front Immunol."},{"issue":"7","key":"B33-20251226","doi-asserted-by":"crossref","first-page":"e20222005","DOI":"10.1084\/jem.20222005","article-title":"TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy","volume":"220","author":"Yamada","year":"2023","journal-title":"J Exp Med."},{"issue":"2","key":"B34-20251226","doi-asserted-by":"crossref","first-page":"e20191520","DOI":"10.1084\/jem.20191520","article-title":"ILC2s are the predominant source of intestinal ILC-derived IL-10","volume":"217","author":"Bando","year":"2020","journal-title":"J Exp Med."},{"issue":"1","key":"B35-20251226","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41467-019-08365-0","article-title":"Runx\/Cbf\u03b2 complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation","volume":"10","author":"Miyamoto","year":"2019","journal-title":"Nat Commun."},{"issue":"12","key":"B36-20251226","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.4049\/jimmunol.170.12.5876","article-title":"Differential regulation of killer cell lectin-like receptor G1 expression on T cells","volume":"170","author":"Robbins","year":"2003","journal-title":"J Immunol."},{"issue":"2","key":"B37-20251226","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity."},{"issue":"1","key":"B38-20251226","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaci.2017.03.010","article-title":"\u03b22 integrins rather than \u03b21 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung","volume":"141","author":"Karta","year":"2018","journal-title":"J Allergy Clin Immunol."},{"issue":"1","key":"B39-20251226","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1084\/jem.20170449","article-title":"IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow","volume":"215","author":"Stier","year":"2018","journal-title":"J Exp Med."},{"issue":"4","key":"B40-20251226","doi-asserted-by":"crossref","first-page":"e20191172","DOI":"10.1084\/jem.20191172","article-title":"Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity","volume":"217","author":"Ricardo-Gonzalez","year":"2020","journal-title":"J Exp Med."},{"issue":"10","key":"B41-20251226","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1097\/01.ASN.0000088027.54400.C6","article-title":"Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury","volume":"14","author":"Mishra","year":"2003","journal-title":"J Am Soc Nephrol."},{"issue":"9","key":"B42-20251226","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1369\/0022155419852932","article-title":"Renal inflammation and fibrosis: a double-edged sword","volume":"67","author":"Black","year":"2019","journal-title":"J Histochem Cytochem."},{"issue":"11","key":"B43-20251226","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1681\/ASN.2010091011","article-title":"IL-33 exacerbates acute kidney injury","volume":"22","author":"Akcay","year":"2011","journal-title":"J Am Soc Nephrol."},{"issue":"4","key":"B44-20251226","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.bbrc.2016.04.010","article-title":"Upregulation of interleukin-33 in obstructive renal injury","volume":"473","author":"Chen","year":"2016","journal-title":"Biochem Biophys Res Commun."},{"issue":"4","key":"B45-20251226","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0047-8","article-title":"IL-33\/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury","volume":"50","author":"Chen","year":"2018","journal-title":"Exp Mol Med."},{"issue":"2","key":"B46-20251226","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2013.07.018","article-title":"Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis","volume":"39","author":"McHedlidze","year":"2013","journal-title":"Immunity."},{"issue":"3","key":"B47-20251226","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/ng.323","article-title":"Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction","volume":"41","author":"Gudbjartsson","year":"2009","journal-title":"Nat Genet."},{"issue":"7","key":"B48-20251226","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/all.14196","article-title":"TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation","volume":"75","author":"Toki","year":"2020","journal-title":"Allergy."},{"issue":"1","key":"B49-20251226","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1038\/s41598-023-36642-y","article-title":"Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE\/EGFR to reduce inflammation and epithelial dysfunction","volume":"13","author":"England","year":"2023","journal-title":"Sci Rep."},{"issue":"3","key":"B50-20251226","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1373\/clinchem.2014.231753","article-title":"Neuromedin U: a multifunctional neuropeptide with pleiotropic roles","volume":"61","author":"Martinez","year":"2015","journal-title":"Clin Chem."},{"issue":"6663","key":"B51-20251226","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1126\/science.ade4177","article-title":"Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine","volume":"381","author":"Li","year":"2023","journal-title":"Science."},{"issue":"76","key":"B52-20251226","doi-asserted-by":"crossref","first-page":"eadd3263","DOI":"10.1126\/sciimmunol.add3263","article-title":"Resident TH2 cells orchestrate adipose tissue remodeling at a site adjacent to infection","volume":"7","author":"Kabat","year":"2022","journal-title":"Sci Immunol."},{"issue":"6383","key":"B53-20251226","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1126\/science.aap9598","article-title":"Neuronal-immune system cross-talk in homeostasis","volume":"359","author":"Veiga-Fernandes","year":"2018","journal-title":"Science."},{"key":"B54-20251226","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-immunol-042718-041812","article-title":"Neuro-immune cell units: a new paradigm in physiology","volume":"37","author":"Godinho-Silva","year":"2019","journal-title":"Annu Rev Immunol."},{"issue":"1","key":"B55-20251226","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.kint.2019.02.011","article-title":"Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia\/reperfusion injury","volume":"96","author":"Hasegawa","year":"2019","journal-title":"Kidney Int."},{"issue":"5","key":"B56-20251226","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1172\/JCI83658","article-title":"Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through \u03b17nAChR+ splenocytes","volume":"126","author":"Inoue","year":"2016","journal-title":"J Clin Invest."},{"issue":"12","key":"B57-20251226","doi-asserted-by":"crossref","first-page":"e2021758118","DOI":"10.1073\/pnas.2021758118","article-title":"Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury","volume":"118","author":"Tanaka","year":"2021","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"B58-20251226","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41385-022-00543-6","article-title":"Neuromedin U promotes human type 2 immune responses","volume":"15","author":"Ye","year":"2022","journal-title":"Mucosal Immunol."},{"issue":"5","key":"B59-20251226","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/acsmedchemlett.8b00105","article-title":"Synthesis and in vitro evaluation of stabilized and selective neuromedin U-1 receptor agonists","volume":"9","author":"De Prins","year":"2018","journal-title":"ACS Med Chem Lett."},{"issue":"2","key":"B60-20251226","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/psc.2727","article-title":"Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake","volume":"21","author":"Dalb\u00f8ge","year":"2015","journal-title":"J Pept Sci."},{"issue":"7","key":"B61-20251226","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1210\/en.2010-1463","article-title":"Effects of peripherally administered neuromedin U on energy and glucose homeostasis","volume":"152","author":"Peier","year":"2011","journal-title":"Endocrinology."},{"issue":"4","key":"B62-20251226","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mai.2001.118600","article-title":"IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism","volume":"108","author":"Pope","year":"2001","journal-title":"J Allergy Clin Immunol."},{"issue":"3","key":"B63-20251226","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.coi.2008.04.001","article-title":"IL-5 and eosinophilia","volume":"20","author":"Takatsu","year":"2008","journal-title":"Curr Opin Immunol."},{"issue":"2","key":"B64-20251226","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jaci.2023.03.023","article-title":"Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice","volume":"152","author":"LeSuer","year":"2023","journal-title":"J Allergy Clin Immunol."},{"issue":"3","key":"B65-20251226","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1084\/jem.179.3.881","article-title":"Eotaxin: a potent eosinophil chemoattractant cytokine detected in a Guinea pig model of allergic airways inflammation","volume":"179","author":"Jose","year":"1994","journal-title":"J Exp Med."},{"issue":"7280","key":"B66-20251226","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature."},{"issue":"1","key":"B67-20251226","doi-asserted-by":"crossref","first-page":"10566","DOI":"10.1038\/s41467-024-54780-3","article-title":"Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells","volume":"15","author":"Troch","year":"2024","journal-title":"Nat Commun."},{"issue":"4","key":"B68-20251226","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1681\/ASN.2009020182","article-title":"B cells limit repair after ischemic acute kidney injury","volume":"21","author":"Jang","year":"2010","journal-title":"J Am Soc Nephrol."},{"issue":"5","key":"B69-20251226","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.4049\/jimmunol.2000454","article-title":"B lymphocyte\u2013derived CCL7 augments neutrophil and monocyte recruitment, exacerbating acute kidney injury","volume":"205","author":"Inaba","year":"2020","journal-title":"J Immunol."},{"issue":"3","key":"B70-20251226","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000501639","article-title":"Role of natural IgM and IgM induced Bregs in preventing ischemia induced innate inflammation and acute kidney injury","volume":"143","author":"Lobo","year":"2019","journal-title":"Nephron."},{"issue":"10","key":"B71-20251226","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1681\/ASN.2018101067","article-title":"Anti-CD45RB antibody therapy attenuates renal ischemia-reperfusion injury by inducing regulatory B cells","volume":"30","author":"Fang","year":"2019","journal-title":"J Am Soc Nephrol."},{"issue":"9","key":"B72-20251226","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1172\/JCI200112080","article-title":"Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure","volume":"108","author":"Burne","year":"2001","journal-title":"J Clin Invest."},{"issue":"2","key":"B73-20251226","doi-asserted-by":"crossref","first-page":"F319","DOI":"10.1152\/ajprenal.00432.2002","article-title":"Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury","volume":"285","author":"Yokota","year":"2003","journal-title":"Am J Physiol Renal Physiol."},{"issue":"5","key":"B74-20251226","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.4049\/jimmunol.1300974","article-title":"Type 2 innate lymphoid cells drive CD4+ Th2 cell responses","volume":"192","author":"Mirchandani","year":"2014","journal-title":"J Immunol."},{"issue":"1","key":"B75-20251226","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.kint.2019.07.019","article-title":"Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia\/reperfusion injury","volume":"97","author":"Cao","year":"2020","journal-title":"Kidney Int."}],"container-title":["Journal of the American Society of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1681\/ASN.0000000747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T18:00:50Z","timestamp":1766772050000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1681\/ASN.0000000747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1681\/asn.0000000747","relation":{},"ISSN":["1046-6673","1533-3450"],"issn-type":[{"value":"1046-6673","type":"print"},{"value":"1533-3450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]},"assertion":[{"value":"2024-11-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}