{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:25:17Z","timestamp":1770135917188,"version":"3.49.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JASN"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>IgA1 mesangial deposition is the hallmark of IgA nephropathy and Henoch\u2013Sch\u00f6nlein purpura, the onset of which often follows infections. Deposited IgA has been reported as polymeric, J chain associated, and often, hypogalactosylated but with no information concerning the influence of the IgA repertoire or the link between immune stimuli and IgA structure. We explored these issues in the <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>1KI mouse model, which produces polyclonal human IgA1 prone to mesangial deposition. Compared with mice challenged by a conventional environment, mice in a specific pathogen\u2013free environment had less IgA deposition. However, serum IgA of specific pathogen\u2013free mice showed more galactosylation and much lower polymerization. Notably, wild-type, <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>1KI, and even J chain\u2013deficient mice showed increased polymeric serum IgA on exposure to pathogens. Strict germfree conditions delayed but did not completely prevent deposition; mice housed in these conditions had very low serum IgA levels and produced essentially monomeric IgA. Finally, comparing monoclonal IgA1 that had different variable regions and mesangial deposition patterns indicated that, independently of glycosylation and polymerization, deposition might also depend on IgA carrying specific variable domains. Together with IgA quantities and constant region post\u2013translational modifications, repertoire changes during immune responses might, thus, modulate IgA propensity to deposition. These IgA features are not associated with circulating immune complexes and C3 deposition and are more pertinent to an initial IgA deposition step preceding overt clinical symptoms in patients.<\/jats:p>","DOI":"10.1681\/asn.2015080911","type":"journal-article","created":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T01:42:03Z","timestamp":1454118123000},"page":"2748-2761","source":"Crossref","is-referenced-by-count":27,"title":["IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition"],"prefix":"10.1681","volume":"27","author":[{"given":"Zeliha","family":"Oruc","sequence":"first","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Christelle","family":"Oblet","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Ahmed","family":"Boumediene","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Anne","family":"Druilhe","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Virginie","family":"Pascal","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Elisabeth","family":"Le Rumeur","sequence":"additional","affiliation":[{"name":"Genetics and Development Instittute, Rennes University, Centre National de la Recherche Scientifique, Rennes, France;"}]},{"given":"Armelle","family":"Cuvillier","sequence":"additional","affiliation":[{"name":"B Cell Design, Limoges, France;"}]},{"given":"Chahrazed","family":"El Hamel","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Sandrine","family":"Lecardeur","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Tomas","family":"Leanderson","sequence":"additional","affiliation":[{"name":"Immunology Group, Lund University, Lund, Sweden;"}]},{"given":"Willy","family":"Morelle","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Laboratory of Structural and Functional Glycobiology, University of Lille 1, France; and"}]},{"given":"Jocelyne","family":"Demengeot","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"}]},{"given":"Jean-Claude","family":"Aldigier","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]},{"given":"Michel","family":"Cogn\u00e9","sequence":"additional","affiliation":[{"name":"Limoges University Hospital Dupuytren, Centre National de la Recherche Scientifique, Limoges University, Limoges, France;"}]}],"member":"276","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"B1-20231016","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJMra020109","article-title":"IgA nephropathy.","volume":"347","author":"Donadio","year":"2002","journal-title":"N Engl J Med"},{"key":"B2-20231016","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1523-1755.2004.00714.x","article-title":"Staphylococcus aureus cell envelope antigen is a new candidate for the induction of IgA nephropathy.","volume":"66","author":"Koyama","year":"2004","journal-title":"Kidney Int"},{"key":"B3-20231016","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1172\/JCI115462","article-title":"Mesangial cell autoantigens in immunoglobulin A nephropathy and Henoch-Sch\u00f6nlein purpura.","volume":"88","author":"O\u2019Donoghue","year":"1991","journal-title":"J Clin Invest"},{"key":"B4-20231016","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000187763","article-title":"Charge distribution of IgA-lambda in IgA nephropathy.","volume":"66","author":"Lai","year":"1994","journal-title":"Nephron"},{"key":"B5-20231016","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1523-1755.2001.00489.x","article-title":"Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy.","volume":"59","author":"Leung","year":"2001","journal-title":"Kidney Int"},{"key":"B6-20231016","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/00365599709070350","article-title":"Analysis of charge distribution of lambda- and kappa-IgA in IgA nephropathy by focused antigen capture immunoassay.","volume":"31","author":"Suen","year":"1997","journal-title":"Scand J Urol Nephrol"},{"key":"B7-20231016","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ki.2009.427","article-title":"IgA nephropathy at two score and one.","volume":"77","author":"Coppo","year":"2010","journal-title":"Kidney Int"},{"key":"B8-20231016","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/sj.ki.5002185","article-title":"Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels.","volume":"71","author":"Moldoveanu","year":"2007","journal-title":"Kidney Int"},{"key":"B9-20231016","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1681\/ASN.2007091052","article-title":"Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy.","volume":"19","author":"Gharavi","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B10-20231016","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1172\/JCI5535","article-title":"Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies.","volume":"104","author":"Tomana","year":"1999","journal-title":"J Clin Invest"},{"key":"B11-20231016","first-page":"1668","article-title":"Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity.","volume":"119","author":"Suzuki","year":"2009","journal-title":"J Clin Invest"},{"key":"B12-20231016","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/ki.1985.76","article-title":"Spontaneous glomerular IgA deposition in ddY mice: An animal model of IgA nephritis.","volume":"27","author":"Imai","year":"1985","journal-title":"Kidney Int"},{"key":"B13-20231016","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1084\/jem.191.11.1999","article-title":"Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger\u2019s disease). 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