{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:16:11Z","timestamp":1791353771915,"version":"4.3.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bulletin du Cancer"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1684\/bdc.2013.1876","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T19:58:43Z","timestamp":1565726323000},"page":"56-67","source":"Crossref","is-referenced-by-count":11,"title":["Historique de la leuc\u00e9mie my\u00e9lo\u00efde chronique : un paradigme de traitement du cancer"],"prefix":"10.1016","volume":"101","author":[{"given":"R.","family":"Gonon-Demoulian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.E.","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1684\/bdc.2013.1876_bib0005","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMra020777","article-title":"Chronic myeloid leukemia \u2013 advances in biology and new approaches to treatment","volume":"349","author":"Goldman","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1684\/bdc.2013.1876_bib0010","first-page":"1497","article-title":"A minute chromosome in human granulocytic leukemia","volume":"132","author":"Nowell","year":"1960","journal-title":"Science"},{"key":"10.1684\/bdc.2013.1876_bib0015","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","article-title":"A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining","volume":"243","author":"Rowley","year":"1973","journal-title":"Nature"},{"key":"10.1684\/bdc.2013.1876_bib0020","first-page":"216","article-title":"Sur la r\u00e9sorption du pus et sur l\u2019alt\u00e9ration du sang dans les maladies","volume":"2","author":"Velpeau","year":"1827","journal-title":"Revue M\u00e9dicale"},{"key":"10.1684\/bdc.2013.1876_bib0025","series-title":"Cours de microscopie compl\u00e9mentaire des \u00e9tudes m\u00e9dicales","first-page":"550","author":"Donn\u00e9","year":"1844"},{"key":"10.1684\/bdc.2013.1876_bib0030","first-page":"400","article-title":"Case of disease of the spleen, in which death took place in consequence of the presence of purulent matter in the blood","volume":"64","author":"Craigie","year":"1845","journal-title":"Edinburgh Med Surg J"},{"key":"10.1684\/bdc.2013.1876_bib0035","first-page":"413","article-title":"Case of hypertrophy of the spleen and liver in which death took place from suppuration of the blood","volume":"64","author":"Bennett","year":"1845","journal-title":"Edinburgh Med Surg J"},{"key":"10.1684\/bdc.2013.1876_bib0040","first-page":"151","article-title":"Weisses Blut","volume":"36","author":"Virchow","year":"1845","journal-title":"Froiep's Notizen."},{"key":"10.1684\/bdc.2013.1876_bib0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2141.2000.02137.x","article-title":"The story of chronic myeloid leukaemia","volume":"110","author":"Geary","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1684\/bdc.2013.1876_bib0050","first-page":"9","article-title":"Weisses Blut und Milztumoren","volume":"16","author":"Virchow","year":"1847","journal-title":"Medicinische Zeitung"},{"key":"10.1684\/bdc.2013.1876_bib0055","series-title":"Leucocythaemia, or white cell blood in relation to the physiology and pathology of the lymphatic glandular system","author":"Bennett","year":"1852"},{"key":"10.1684\/bdc.2013.1876_bib0060","series-title":"Die Leuk\u00e4mie. Gesammelte Abhandlungen Zur Wissenschaftlichen Medizin","first-page":"190","author":"Virchow","year":"1856"},{"key":"10.1684\/bdc.2013.1876_bib0065","unstructured":"Ehrlich P. \u00dcber die specifischen granulationen des blutes. Berlin : Arch Anat Phys ; 1879.(p 571-9)."},{"key":"10.1684\/bdc.2013.1876_bib0070","series-title":"Farbenanalytische Untersuchungen Zur Histologie und Klinik Des Blutes","author":"Ehrlich","year":"1891"},{"key":"10.1684\/bdc.2013.1876_bib0075","series-title":"In Zur Frage der Entstehung Maligner Tumoren","author":"Boveri","year":"1914"},{"key":"10.1684\/bdc.2013.1876_bib0080","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1172\/JCI31771","article-title":"Discovery of the Philadelphia chromosome : a personal perspective","volume":"117","author":"Nowell","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1684\/bdc.2013.1876_bib0085","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0140-6736(61)90001-0","article-title":"Cytogenetic studies in chronic myeloid leukaemia and acute leukaemia associated with monogolism","volume":"1","author":"Tough","year":"1961","journal-title":"Lancet"},{"key":"10.1684\/bdc.2013.1876_bib0090","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/2598","article-title":"Cancer genetics, cytogenetics \u2013 defining the enemy within","volume":"4","author":"Nowell","year":"1998","journal-title":"Nat Med"},{"key":"10.1684\/bdc.2013.1876_bib0095","first-page":"2213","article-title":"Lymphosarcoma: virus-induced thymic-independent disease in mice","volume":"30","author":"Abelson","year":"1970","journal-title":"Cancer Res"},{"key":"10.1684\/bdc.2013.1876_bib0100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0065-230X(02)85003-5","article-title":"The Abl family kinases: mechanisms of regulation and signaling","volume":"85","author":"Pendergast","year":"2002","journal-title":"Adv Cancer Res"},{"key":"10.1684\/bdc.2013.1876_bib0105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(03)00196-X","article-title":"Variation on an Src-like theme","volume":"112","author":"Harrison","year":"2003","journal-title":"Cell"},{"key":"10.1684\/bdc.2013.1876_bib0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(84)90077-1","article-title":"Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22","volume":"36","author":"Groffen","year":"1984","journal-title":"Cell"},{"key":"10.1684\/bdc.2013.1876_bib0115","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood.V88.7.2375.bloodjournal8872375","article-title":"The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype","volume":"88","author":"Melo","year":"1996","journal-title":"Blood"},{"key":"10.1684\/bdc.2013.1876_bib0120","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.2408149","article-title":"Tyrosine kinase activity and transformation potency of bcr-abl oncogene products","volume":"247","author":"Lugo","year":"1990","journal-title":"Science"},{"key":"10.1684\/bdc.2013.1876_bib0125","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","article-title":"Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome","volume":"247","author":"Daley","year":"1990","journal-title":"Science"},{"key":"10.1684\/bdc.2013.1876_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1634\/theoncologist.6-suppl_2-1","article-title":"Introduction: the history of arsenic trioxide in cancer therapy","volume":"6","author":"Antman","year":"2001","journal-title":"The Oncologist"},{"key":"10.1684\/bdc.2013.1876_bib0135","first-page":"403","article-title":"Zwei F\u00e4lle von Leuk\u00e4mie","volume":"2","author":"Lissauer","year":"1865","journal-title":"Berl Klin Wochenschr"},{"key":"10.1684\/bdc.2013.1876_bib0140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00000441-187801000-00004","article-title":"Action of iron, cod-liver oil, and arsenic on the globular richness of the blood","volume":"75","author":"Cutler","year":"1878","journal-title":"Am J Med Sci"},{"key":"10.1684\/bdc.2013.1876_bib0145","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0140-6736(02)21638-4","article-title":"Notes on a case of leucocythaemia","volume":"25","author":"Conan Doyle","year":"1882","journal-title":"Lancet"},{"key":"10.1684\/bdc.2013.1876_bib0150","first-page":"305","article-title":"Arsenic as a therapeutic agent in chronic myeloid leukemia","volume":"97","author":"Forkner","year":"1931","journal-title":"Jama"},{"key":"10.1684\/bdc.2013.1876_bib0155","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ccr.2010.06.003","article-title":"PML\/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3","volume":"18","author":"Jeanne","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1684\/bdc.2013.1876_bib0160","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nature07016","article-title":"PML targeting eradicates quiescent leukaemia-initiating cells","volume":"453","author":"Ito","year":"2008","journal-title":"Nature"},{"key":"10.1684\/bdc.2013.1876_bib0165","first-page":"281","article-title":"Case of splenomedullary leukemia successfully treated by the use of Roentgen rays","volume":"64","author":"Senn","year":"1903","journal-title":"Med Rec"},{"key":"10.1684\/bdc.2013.1876_bib0170","first-page":"497","article-title":"The Blood and Bone Marrow in Yellow Cross Gas (Mustard Gas) Poisoning","volume":"40","author":"Krumbhaar","year":"1919","journal-title":"J Med Res"},{"key":"10.1684\/bdc.2013.1876_bib0175","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0002-9610(63)90232-0","article-title":"The initial clinical trial of nitrogen mustard","volume":"105","author":"Gilman","year":"1961","journal-title":"Am J Surg"},{"key":"10.1684\/bdc.2013.1876_bib0180","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0140-6736(47)90586-2","article-title":"Effect of beta-chloroethylamine hydrochlorides in leukaemia, Hodgkin's disease, and polycythaemia vera; report on 18 cases","volume":"2","author":"Wilkinson","year":"1947","journal-title":"Lancet"},{"key":"10.1684\/bdc.2013.1876_bib0185","first-page":"203","article-title":"Nitrogen mustard treatment in chronic myelogenous leukemia","volume":"44","author":"Siddon","year":"1948","journal-title":"J Ark Med Soc"},{"key":"10.1684\/bdc.2013.1876_bib0190","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0140-6736(53)90884-8","article-title":"Myleran in chronic myeloid leukaemia; chemical constitution and biological action","volume":"264","author":"Haddow","year":"1953","journal-title":"Lancet"},{"key":"10.1684\/bdc.2013.1876_bib0195","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1749-6632.1958.tb42652.x","article-title":"Busulfan: Summary of clinical results","volume":"68","author":"Galton","year":"1958","journal-title":"Ann New York Acad Sc"},{"key":"10.1684\/bdc.2013.1876_bib0200","first-page":"1517","article-title":"An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the American Society of Hematology","volume":"94","author":"Silver","year":"1999","journal-title":"Blood"},{"key":"10.1684\/bdc.2013.1876_bib0205","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1056\/NEJM198601233140403","article-title":"Bone marrow transplantation for patients with chronic myeloid leukemia","volume":"314","author":"Goldman","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1684\/bdc.2013.1876_bib0210","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJM197902153000702","article-title":"Disappearance of Ph1-positive cells in four patients with chronic granulocytic leukemia after chemotherapy, irradiation and marrow transplantation from an identical twin","volume":"300","author":"Fefer","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1684\/bdc.2013.1876_bib0215","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0140-6736(82)92736-2","article-title":"Marrow transplantation for patients in the chronic phase of chronic granulocytic leukaemia","volume":"2","author":"Goldman","year":"1982","journal-title":"Lancet"},{"key":"10.1684\/bdc.2013.1876_bib0220","first-page":"513","volume":"91","author":"Gratwohl","year":"2006","journal-title":"Haematologica"},{"key":"10.1684\/bdc.2013.1876_bib0225","first-page":"1700","article-title":"Immunizing property of vaccinia virus inactivated by ultraviolets rays","volume":"148","author":"Nagano","year":"1954","journal-title":"C R Seances Soc Biol Fil"},{"key":"10.1684\/bdc.2013.1876_bib0230","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/jir.1987.7.429","article-title":"Virus interference. I. The interferon. By A Isaacs and J Lindenmann, 1957","volume":"7","author":"Isaacs","year":"1987","journal-title":"J Interferon Res"},{"key":"10.1684\/bdc.2013.1876_bib0235","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood.V62.3.689.689","article-title":"Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia","volume":"62","author":"Talpaz","year":"1983","journal-title":"Blood"},{"key":"10.1684\/bdc.2013.1876_bib0240","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1056\/NEJM199707243370402","article-title":"Interferon alfa-2b combined with cytarabine versus interferon alone in chronic myelogenous leukemia. French Chronic Myeloid Leukemia Study Group","volume":"337","author":"Guilhot","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1684\/bdc.2013.1876_bib0245","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1182\/blood.V84.12.4064.bloodjournal84124064","article-title":"Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML Study Group","volume":"84","author":"Hehlmann","year":"1994","journal-title":"Blood"},{"key":"10.1684\/bdc.2013.1876_bib0250","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1016\/S0021-9258(18)42864-5","article-title":"Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins","volume":"267","author":"Anafi","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1684\/bdc.2013.1876_bib0255","first-page":"4492","article-title":"Benzopyranones and benzothiopyranones: a class of tyrosine protein kinase inhibitors with selectivity for the v-abl kinase","volume":"52","author":"Geissler","year":"1992","journal-title":"Cancer Res"},{"key":"10.1684\/bdc.2013.1876_bib0260","first-page":"100","article-title":"Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative","volume":"56","author":"Buchdunger","year":"1996","journal-title":"Cancer Res"},{"key":"10.1684\/bdc.2013.1876_bib0265","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1182\/blood-2008-07-077958","article-title":"Translation of the Philadelphia chromosome into therapy for CML","volume":"112","author":"Druker","year":"2008","journal-title":"Blood"},{"key":"10.1684\/bdc.2013.1876_bib0270","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","article-title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells","volume":"2","author":"Druker","year":"1996","journal-title":"Nat Med"},{"key":"10.1684\/bdc.2013.1876_bib0275","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1182\/blood.V99.6.1928","article-title":"Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study","volume":"99","author":"Talpaz","year":"2002","journal-title":"Blood"},{"key":"10.1684\/bdc.2013.1876_bib0280","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1056\/NEJMoa022457","article-title":"Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia","volume":"348","author":"O\u2019Brien","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1684\/bdc.2013.1876_bib0285","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/cncr.23655","article-title":"Therapeutic advances in Leukemia and myelodysplastic syndromes over the past 40 years","volume":"113","author":"Kantarjian","year":"2008","journal-title":"Cancer"},{"key":"10.1684\/bdc.2013.1876_bib0290","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1056\/NEJMoa1002315","article-title":"Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia","volume":"362","author":"Kantarjian","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1684\/bdc.2013.1876_bib0295","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1056\/NEJMoa0912614","article-title":"Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia","volume":"362","author":"Saglio","year":"2010","journal-title":"N Engl J Med"}],"container-title":["Bulletin du Cancer"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455115301521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455115301521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T17:16:50Z","timestamp":1610817410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007455115301521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0007455115301521"],"URL":"https:\/\/doi.org\/10.1684\/bdc.2013.1876","relation":{},"ISSN":["0007-4551"],"issn-type":[{"value":"0007-4551","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}