{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:36:14Z","timestamp":1787499374433,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bulletin du Cancer"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1684\/bdc.2014.2031","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T15:58:43Z","timestamp":1565711923000},"page":"966-975","source":"Crossref","is-referenced-by-count":10,"title":["Pheochromocytomes et paragangliomes p\u00e9diatriques: revue de la litt\u00e9rature"],"prefix":"10.1016","volume":"101","author":[{"given":"Sarah","family":"Garnier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"R\u00e9guerre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Brugi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kalfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1684\/bdc.2014.2031_bib0005","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.5858\/2008-132-1272-PAEPU","article-title":"Pheochromocytoma and extra-adrenal paraganglioma: updates","volume":"132","author":"Tischler","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"10.1684\/bdc.2014.2031_bib0010","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1053\/jpsu.2001.21612","article-title":"Pheochromocytoma in children","volume":"36","author":"Ciftci","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1684\/bdc.2014.2031_bib0015","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1210\/jc.2008-2291","article-title":"Clinical review: prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review","volume":"94","author":"Golden","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0020","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/adc.2008.139121","article-title":"Phaeochromocytoma in children","volume":"93","author":"Armstrong","year":"2008","journal-title":"Arch Dis Child"},{"key":"10.1684\/bdc.2014.2031_bib0025","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00467-008-0888-9","article-title":"Update on pediatric pheochromocytoma","volume":"24","author":"Havekes","year":"2009","journal-title":"Pediatr Nephrol"},{"key":"10.1684\/bdc.2014.2031_bib0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1196\/annals.1353.003","article-title":"Characteristics of pheochromocytoma in a 4- to 20-year-old population","volume":"1073","author":"Barontini","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1684\/bdc.2014.2031_bib0035","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.amjsurg.2007.08.028","article-title":"Recent advances in the diagnosis and treatment of pheochromocytoma in children","volume":"194","author":"Ludwig","year":"2007","journal-title":"Am J Surg"},{"key":"10.1684\/bdc.2014.2031_bib0040","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1210\/jc.2009-2830","article-title":"A current review of the etiology, diagnosis, and treatment of pediatric pheochromocytoma and paraganglioma","volume":"95","author":"Waguespack","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0045","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jpedsurg.2007.10.038","article-title":"Pheochromocytoma in children and adolescents: a clinical spectrum","volume":"43","author":"Bissada","year":"2008","journal-title":"J Pediatr Surg"},{"key":"10.1684\/bdc.2014.2031_bib0050","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1210\/jcem.87.5.8446","article-title":"Utility of plasma free metanephrines for detecting childhood pheochromocytoma","volume":"87","author":"Weise","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0055","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ncpendmet0396","article-title":"Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005","volume":"3","author":"Pacak","year":"2007","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cancergen.2012.01.009","article-title":"Pheochromocytoma and paraganglioma: understanding the complexities of the genetic background","volume":"205","author":"Fishbein","year":"2012","journal-title":"Cancer Genet"},{"issue":"10","key":"10.1684\/bdc.2014.2031_bib0065","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","article-title":"SDH mutations establish a hypermethylator phenotype in paraganglioma","volume":"23","author":"Letouze","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1684\/bdc.2014.2031_bib0070","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1210\/jcem.86.5.7496","article-title":"Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2display distinct biochemical and clinical phenotypes","volume":"86","author":"Eisenhofer","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0075","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1210\/jc.2004-2025","article-title":"Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine","volume":"90","author":"Eisenhofer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0080","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/jnci\/djs188","article-title":"Staging and functional characterization of pheochromocytoma and paraganglioma by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography","volume":"104","author":"Timmers","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"10.1684\/bdc.2014.2031_bib0085","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00247-011-2109-0","article-title":"Novel use of F-DOPA PET\/CT imaging in a child with paraganglioma\/pheochromocytoma syndrome","volume":"41","author":"Levine","year":"2011","journal-title":"Pediatr Radiol"},{"key":"10.1684\/bdc.2014.2031_bib0090","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.2967\/jnumed.108.058701","article-title":"Usefulness of 123I-MIBG scintigraphy in the evaluation of patients with known or suspected primary or metastatic pheochromocytoma or paraganglioma: results from a prospective multicenter trial","volume":"50","author":"Wiseman","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1684\/bdc.2014.2031_bib0095","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/pbc.24555","article-title":"Update on pediatric cancer predisposition syndromes","volume":"60","author":"Schiffman","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1684\/bdc.2014.2031_bib0100","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1056\/NEJMoa020152","article-title":"Germ-line mutations in nonsyndromic pheochromocytoma","volume":"346","author":"Neumann","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1684\/bdc.2014.2031_bib0105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc3648","article-title":"Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity","volume":"14","author":"Dahia","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1684\/bdc.2014.2031_bib0110","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1196\/annals.1353.017","article-title":"Frequent genetic changes in childhood pheochromocytomas","volume":"1073","author":"De Krijger","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1684\/bdc.2014.2031_bib0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/107327481101800205","article-title":"Changing paradigms in the treatment of malignant pheochromocytoma","volume":"18","author":"Grogan","year":"2011","journal-title":"Cancer Control"},{"key":"10.1684\/bdc.2014.2031_bib0120","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/prot.22419","article-title":"Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis","volume":"77","author":"Forman","year":"2009","journal-title":"Proteins"},{"key":"10.1684\/bdc.2014.2031_bib0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.14310\/horm.2002.1218","article-title":"Genotype-phenotype relationship in multiple endocrine neoplasia type 2. Implications for clinical management","volume":"8","author":"Raue","year":"2009","journal-title":"Hormones (Athens)"},{"key":"10.1684\/bdc.2014.2031_bib0130","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2005-1862","article-title":"Clinical presentation and penetrance of pheochromocytoma\/paraganglioma syndromes","volume":"91","author":"Benn","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0135","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1200\/JCO.2011.34.6353","article-title":"Metastatic pheochromocytoma\/paraganglioma related to primary tumor development in childhood or adolescence: significant link to SDHB mutations","volume":"29","author":"King","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1684\/bdc.2014.2031_bib0140","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2265.2006.02714.x","article-title":"Phaeochromocytoma, new genes and screening strategies","volume":"65","author":"Gimenez-Roqueplo","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1684\/bdc.2014.2031_bib0145","first-page":"105","article-title":"Achievements of the COMETE program in the genetics of pheochromocytoma","volume":"192","author":"Gimenez-Roqueplo","year":"2008","journal-title":"Bull Acad Natl Med"},{"key":"10.1684\/bdc.2014.2031_bib0150","doi-asserted-by":"crossref","first-page":"E162","DOI":"10.1210\/jc.2012-2975","article-title":"Imaging work-up for screening of paraganglioma and pheochromocytoma in SDHx mutation carriers: a multicenter prospective study from the PGL.EVA Investigators","volume":"98","author":"Gimenez-Roqueplo","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0155","doi-asserted-by":"crossref","first-page":"872713","DOI":"10.1155\/2012\/872713","article-title":"Updated and new perspectives on diagnosis, prognosis, and therapy of malignant pheochromocytoma\/paraganglioma","volume":"2012","author":"Parenti","year":"2012","journal-title":"J Oncol"},{"key":"10.1684\/bdc.2014.2031_bib0160","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1542\/peds.2005-2299","article-title":"Pheochromocytoma and paraganglioma in children: a review of medical and surgical management at a tertiary care center","volume":"118","author":"Pham","year":"2006","journal-title":"Pediatrics"},{"key":"10.1684\/bdc.2014.2031_bib0165","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.surg.2009.09.013","article-title":"Biopsy of pheochromocytomas and paragangliomas: potential for disaster","volume":"146","author":"Vanderveen","year":"2009","journal-title":"Surgery"},{"key":"10.1684\/bdc.2014.2031_bib0170","first-page":"45","article-title":"Experience with laparoscopic adrenalectomy in children","volume":"58","author":"Pampaloni","year":"2006","journal-title":"Chir Ital"},{"key":"10.1684\/bdc.2014.2031_bib0175","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1053\/jpsu.2002.33822","article-title":"Experience with laparoscopic adrenalectomy in pediatric patients","volume":"37","author":"Miller","year":"2002","journal-title":"J Pediatr Surg"},{"key":"10.1684\/bdc.2014.2031_bib0180","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/00000478-200205000-00002","article-title":"Pheochromocytoma of the Adrenal gland Scaled Score (PASS) to separate benign from malignant neoplasms: a clinicopathologic and immunophenotypic study of 100cases","volume":"26","author":"Thompson","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1684\/bdc.2014.2031_bib0185","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00268-004-7134-9","article-title":"Pheochromocytoma surgery: epidemiologic peculiarities in children","volume":"28","author":"Beltsevich","year":"2004","journal-title":"World J Surg"},{"key":"10.1684\/bdc.2014.2031_bib0190","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ajem.2008.08.023","article-title":"Pheochromocytoma presenting as massive hemoptysis and acute respiratory failure","volume":"27","author":"Yoshida","year":"2009","journal-title":"Am J Emerg Med"},{"key":"10.1684\/bdc.2014.2031_bib0195","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jpedsurg.2011.08.003","article-title":"Minimally invasive adrenalectomy in children","volume":"47","author":"Heloury","year":"2012","journal-title":"J Pediatr Surg"},{"key":"10.1684\/bdc.2014.2031_bib0200","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jc.2013-1907","article-title":"One-year progression-free survival of therapy-naive patients with malignant pheochromocytoma and paraganglioma","volume":"98","author":"Hescot","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0205","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jvir.2011.06.016","article-title":"Minimally invasive treatment of metastatic pheochromocytoma and paraganglioma: efficacy and safety of radiofrequency ablation and cryoablation therapy","volume":"22","author":"McBride","year":"2011","journal-title":"J Vasc Interv Radiol"},{"key":"10.1684\/bdc.2014.2031_bib0210","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1196\/annals.1353.050","article-title":"Malignant pheochromocytomas and paragangliomas: a phase II study of therapy with high-dose 131I-metaiodobenzylguanidine (131I-MIBG)","volume":"1073","author":"Fitzgerald","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1684\/bdc.2014.2031_bib0215","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1200\/JCO.2008.21.3496","article-title":"Phase II study of high-dose [131I]metaiodobenzylguanidine therapy for patients with metastatic pheochromocytoma and paraganglioma","volume":"27","author":"Gonias","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1684\/bdc.2014.2031_bib0220","first-page":"vii","article-title":"IPEG guidelines for the surgical treatment of adrenal masses in children","volume":"20","year":"2010","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"10.1684\/bdc.2014.2031_bib0225","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF03348026","article-title":"The treatment of malignant pheochromocytoma with iodine-131metaiodobenzylguanidine (131I-MIBG): a comprehensive review of 116reported patients","volume":"20","author":"Loh","year":"1997","journal-title":"J Endocrinol Invest"},{"key":"10.1684\/bdc.2014.2031_bib0230","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/cncr.11518","article-title":"High-dose 131I-metaiodobenzylguanidine therapy for 12patients with malignant pheochromocytoma","volume":"98","author":"Rose","year":"2003","journal-title":"Cancer"},{"key":"10.1684\/bdc.2014.2031_bib0235","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1210\/jc.2003-030262","article-title":"Somatostatin receptor subtypes in human pheochromocytoma: subcellular expression pattern and functional relevance for octreotide scintigraphy","volume":"88","author":"Mundschenk","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1684\/bdc.2014.2031_bib0240","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0039-6060(03)00426-4","article-title":"Iodine -131metaiodobenzylguanidine is an effective treatment for malignant pheochromocytoma and paraganglioma","volume":"134","author":"Safford","year":"2003","journal-title":"Surgery"},{"key":"10.1684\/bdc.2014.2031_bib0245","doi-asserted-by":"crossref","first-page":"267","DOI":"10.7326\/0003-4819-109-4-267","article-title":"Malignant pheochromocytoma: effective treatment with a combination of cyclophosphamide, vincristine, and dacarbazine","volume":"109","author":"Averbuch","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1684\/bdc.2014.2031_bib0250","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/cncr.23812","article-title":"Treatment of malignant pheochromocytoma\/paraganglioma with cyclophosphamide, vincristine, and dacarbazine: recommendation from a 22-year follow-up of 18patients","volume":"113","author":"Huang","year":"2008","journal-title":"Cancer"},{"key":"10.1684\/bdc.2014.2031_bib0255","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12672-013-0133-2","article-title":"Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine in patients with malignant pheochromocytoma and paraganglioma","volume":"4","author":"Tanabe","year":"2013","journal-title":"Horm Cancer"},{"key":"10.1684\/bdc.2014.2031_bib0260","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/cncr.26577","article-title":"Clinical benefits of systemic chemotherapy for patients with metastatic pheochromocytomas or sympathetic extra-adrenal paragangliomas: insights from the largest single-institutional experience","volume":"118","author":"Ayala-Ramirez","year":"2012","journal-title":"Cancer"},{"key":"10.1684\/bdc.2014.2031_bib0265","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12020-010-9422-5","article-title":"Malignant pheochromocytoma: predictive factors of malignancy and clinical course in 16patients at a single tertiary medical center","volume":"39","author":"Szalat","year":"2011","journal-title":"Endocrine"},{"key":"10.1684\/bdc.2014.2031_bib0270","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1055\/s-0029-1220687","article-title":"Novel and evolving therapies in the treatment of malignant phaeochromocytoma: experience with the mTOR inhibitor everolimus (RAD001)","volume":"41","author":"Druce","year":"2009","journal-title":"Horm Metab Res"},{"issue":"3","key":"10.1684\/bdc.2014.2031_bib0275","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1200\/JCO.2005.03.6046","article-title":"Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors","volume":"24","author":"Kulke","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1684\/bdc.2014.2031_bib0280","first-page":"2231","article-title":"Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma","volume":"125","author":"Sun","year":"2012","journal-title":"Chin Med J (Engl)"}],"container-title":["Bulletin du Cancer"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455115300266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455115300266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T12:15:45Z","timestamp":1664108145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007455115300266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0007455115300266"],"URL":"https:\/\/doi.org\/10.1684\/bdc.2014.2031","relation":{},"ISSN":["0007-4551"],"issn-type":[{"value":"0007-4551","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}