{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:59:54Z","timestamp":1790675994317,"version":"4.1.0"},"reference-count":34,"publisher":"Tech Science Press","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Cytokine Netw"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1684\/ecn.2019.0440","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:53:21Z","timestamp":1697824401000},"page":"160-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of cytokines on NK cell activity and activating receptor expression in high-risk cutaneous melanoma patients"],"prefix":"10.32604","volume":"30","author":[{"given":"Katarina Mirja\u010di\u0107","family":"Martinovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Mili\u0107evi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette K","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radan","family":"D\u017eodi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Juri\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Konjevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vuleti\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17807","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"440_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.imbio.2015.07.012","volume":"222","author":"J Pahl","year":"2017","unstructured":"Pahl J, Cerwenka A. Tricking the balance: NK cells in anti-cancer immunity. Immunobiology 2017; 222: 11.","journal-title":"Immunobiology"},{"key":"440_CR2","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1600-065X.2006.00460.x","volume":"214","author":"S Gasser","year":"2006","unstructured":"Gasser S, Raulet DH. Activation and self-tolerance of natural killer cells. Immunol Rev 2006; 214: 130.","journal-title":"Immunol Rev"},{"key":"440_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.smim.2006.03.002","volume":"18","author":"L Moretta","year":"2006","unstructured":"Moretta L, Bottino C, Pende D, Castriconi R, Mingari MC, Moretta A. Surface NK receptors and their ligands on tumor cells. Semin Immunol 2006; 18: 151.","journal-title":"Semin Immunol"},{"key":"440_CR4","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1158\/2326-6066.CIR-15-0098","volume":"3","author":"LL Lanier","year":"2015","unstructured":"Lanier LL. NKG2D receptor and its ligands in host defense. Cancer Immunol Res 2015; 3: 575.","journal-title":"Cancer Immunol Res"},{"key":"440_CR5","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.4049\/jimmunol.161.7.3493","volume":"161","author":"L Azzoni","year":"1998","unstructured":"Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B. Differential transcriptional regulation of CD161 and a novel gene, 197\/15a, by IL-2, IL-15, and IL-12 in NK and T cells. J Immunol 1998; 161: 3493.","journal-title":"J Immunol"},{"key":"440_CR6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3389\/fimmu.2014.00214","volume":"5","author":"CL Kirkham","year":"2014","unstructured":"Kirkham CL, Carlyle JR. Complexity and diversity of the NKR-P1:Clr (Klrb1:Clec2) recognition systems. Front Immunol 2014; 5: 214.","journal-title":"Front Immunol"},{"key":"440_CR7","doi-asserted-by":"publisher","first-page":"7791","DOI":"10.4049\/jimmunol.175.12.7791","volume":"175","author":"H Aldemir","year":"2005","unstructured":"Aldemir H, Prod\u2019homme V, Dumaurier MJ, et al. Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor. J Immunol 2005; 175: 7791.","journal-title":"J Immunol"},{"key":"440_CR8","doi-asserted-by":"publisher","first-page":"7796","DOI":"10.4049\/jimmunol.175.12.7796","volume":"175","author":"DB Rosen","year":"2005","unstructured":"Rosen DB, Bettadapura J, Alsharifi M, Mathew PA, Warren HS, Lanier LL. Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. J Immunol 2005; 175: 7796.","journal-title":"J Immunol"},{"key":"440_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","volume":"11","author":"HG Ljunggren","year":"1990","unstructured":"Ljunggren HG, K\u00e4rre K. In search of the \u2019missing self\u2019: MHC molecules andNKcell recognition. Immunol Today 1990; 11: 237.","journal-title":"Immunol Today"},{"key":"440_CR10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.coi.2012.01.001","volume":"24","author":"A Thielens","year":"2012","unstructured":"Thielens A, Vivier E, Romagn\u00e9 F. NK cell MHC class I specific receptors (KIR): from biology to clinical intervention. Curr Opin Immunol 2012; 24: 239.","journal-title":"Curr Opin Immunol"},{"key":"440_CR11","doi-asserted-by":"publisher","first-page":"500","DOI":"10.4065\/81.4.500","volume":"81","author":"DL Cummins","year":"2006","unstructured":"Cummins DL, Cummins JM, Pantle H, Silverman MA, Leonard AL, Chanmugam A. Cutaneous malignant melanoma. Mayo Clin Proc 2006; 81: 500.","journal-title":"Mayo Clin Proc"},{"key":"440_CR12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/ced.13023","volume":"42","author":"C Mignogna","year":"2017","unstructured":"Mignogna C, Scali E, Camastra C, et al. Innate immunity in cutaneous melanoma. Clin Exp Dermatol 2017; 42: 243.","journal-title":"Clin Exp Dermatol"},{"key":"440_CR13","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1080\/13547500902814658","volume":"14","author":"G Konjevi\u0107","year":"2009","unstructured":"Konjevi\u0107 G, Mirjaci\u0107 Martinovi\u0107 K, Jurisi\u0107 V, Babovi\u0107 N, Spuzi\u0107 I. Biomarkers of suppressed natural killer (NK) cell function in metastatic melanoma: decreased NKG2D and increased CD158a receptors on CD3-CD16+ NK cells. Biomarkers 2009; 14: 258.","journal-title":"Biomarkers"},{"key":"440_CR14","doi-asserted-by":"publisher","first-page":"e76928","DOI":"10.1371\/journal.pone.0076928","volume":"8","author":"G Fregni","year":"2013","unstructured":"Fregni G, Messaoudene M, Fourmentraux-Neves E, et al. Phenotypic and functional characteristics of blood natural killer cells from melanoma patients at different clinical stages. PLoS One 2013; 8: e76928.","journal-title":"PLoS One"},{"key":"440_CR15","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/CMR.0000000000000072","volume":"24","author":"KM Mirja\u010di\u0107 Martinovi\u0107","year":"2014","unstructured":"Mirja\u010di\u0107 Martinovi\u0107 KM, Babovi\u0107 NLj, Dzodi\u0107 RR, Juri\u0161i\u0107 VB, Tani\u0107 NT, Konjevi\u0107 GM. Decreased expression of NKG2D, NKp46, DNAM-1 receptors, and intracellular perforin and STAT-1 effector molecules in NK cells and their dim and bright subsets in metastatic melanoma patients. Melanoma Res 2014; 24: 295.","journal-title":"Melanoma Res"},{"key":"440_CR16","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.critrevonc.2015.11.011","volume":"98","author":"RJ Davey","year":"2016","unstructured":"Davey RJ, van der Westhuizen A, Bowden NA. Metastatic melanoma treatment: combining old and new therapies. Crit Rev Oncol Hematol 2016; 98: 242.","journal-title":"Crit Rev Oncol Hematol"},{"key":"440_CR17","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.hoc.2014.02.001","volume":"28","author":"EI Buchbinder","year":"2014","unstructured":"Buchbinder EI, McDermott DF. Interferon, interleukin-2 and other cytokines. Hematol Oncol Clin North Am 2014; 28: 571.","journal-title":"Hematol Oncol Clin North Am"},{"key":"440_CR18","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/bjd.16892","volume":"179","author":"SG Keohane","year":"2018","unstructured":"Keohane SG, Proby CM, Newlands C, et al. The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, U.K. Br J Dermatol 2018; 179: 824.","journal-title":"Br J Dermatol"},{"key":"440_CR19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0022-1759(85)90205-4","volume":"81","author":"RL Brown","year":"1985","unstructured":"Brown RL, Ortaldo JR, Griffith RL, Blanca I, Rabin H. The proliferation and function of human mononuclear leukocytes and natural killer cells in serum-free medium. J Immunol Methods 1985; 81: 207.","journal-title":"J Immunol Methods"},{"key":"440_CR20","unstructured":"Jackson A, Warner N. Preparation, staining, and analysis by flow cytometry of peripheral blood leukocytes. In: Rose N, Friedmah H, Fahey J, (eds). Manual of Clinical Laboratory Immunology. Washington DC: American Society for Microbiology."},{"key":"440_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1517\/14728222.2012.681378","volume":"16","author":"Y Hayakawa","year":"2012","unstructured":"Hayakawa Y. Targeting NKG2D in tumor surveillance. Expert Opin Ther Targets 2012; 16: 587.","journal-title":"Expert Opin Ther Targets"},{"key":"440_CR22","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3389\/fimmu.2017.00760","volume":"8","author":"J Bi","year":"2017","unstructured":"Bi J, Tian Z. NK cell exhaustion. Front Immunol 2017; 8: 760.","journal-title":"Front Immunol"},{"key":"440_CR23","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1002\/eji.201344272","volume":"44","author":"M Vitale","year":"2014","unstructured":"Vitale M, Cantoni C, Pietra G, Mingari MC, Moretta L. Effect of tumor cells and tumor microenvironment on NK-cell function. Eur J Immunol 2014; 44: 1582.","journal-title":"Eur J Immunol"},{"key":"440_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.it.2010.04.002","volume":"31","author":"L Yang","year":"2010","unstructured":"Yang L, Pang Y, Moses HL. TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol 2010; 31: 220.","journal-title":"Trends Immunol"},{"key":"440_CR25","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1182\/blood-2011-04-346825","volume":"118","author":"YP Park","year":"2011","unstructured":"Park YP, Choi SC, Kiesler P, et al. Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the \u03c8c cytokines and TGF-\u03b21. Blood 2011; 118: 3019.","journal-title":"Blood"},{"key":"440_CR26","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1177\/030089161109700316","volume":"97","author":"JC Lee","year":"2011","unstructured":"Lee JC, Lee KM, Ahn YO, Suh B, Heo DS. A possible mechanism of impaired NK cytotoxicity in cancer patients: down-regulation of DAP10 by TGF-beta1. Tumori 2011; 97: 350.","journal-title":"Tumori"},{"key":"440_CR27","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/bs.ircmb.2016.09.007","volume":"330","author":"A Lapeyre-Prost","year":"2017","unstructured":"Lapeyre-Prost A, Terme M, Pernot S, et al. Immunomodulatory activity of VEGF in cancer. Int Rev Cell Mol Biol 2017; 330: 295.","journal-title":"Int Rev Cell Mol Biol"},{"key":"440_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0304-3835(97)00499-0","volume":"125","author":"J Viac","year":"1998","unstructured":"Viac J, Schmitt D, Claudy A. Circulating vascular endothelial growth factor (VEGF) is not a prognostic indicator in malignant melanoma. Cancer Lett 1998; 125: 35.","journal-title":"Cancer Lett"},{"key":"440_CR29","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/j.1365-2133.2005.06507.x","volume":"152","author":"F Pelletier","year":"2005","unstructured":"Pelletier F, Bermont L, Puzenat E, et al. Circulating vascular endothelial growth factor in cutaneous malignant melanoma. Br J Dermatol 2005; 152: 685.","journal-title":"Br J Dermatol"},{"key":"440_CR30","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/biof.107","volume":"36","author":"NW Zwirner","year":"2010","unstructured":"Zwirner NW, Domaica CI. Cytokine regulation of natural killer cell effector functions. Biofactors 2010; 36: 274.","journal-title":"Biofactors"},{"key":"440_CR31","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1158\/0008-5472.CAN-11-3379","volume":"72","author":"M Terme","year":"2012","unstructured":"Terme M, Ullrich E, Aymeric L, et al. Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells. Cancer Res 2012; 72: 2757.","journal-title":"Cancer Res"},{"key":"440_CR32","doi-asserted-by":"publisher","first-page":"651","DOI":"10.14694\/EDBK_174930","volume":"37","author":"AA Tarhini","year":"2017","unstructured":"Tarhini AA, Lorigan P, Leachman S. Operable melanoma: screening, prognostication, and adjuvant and neoadjuvant therapy. Am Soc Clin Oncol Educ Book 2017; 37: 651.","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"440_CR33","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1080\/14712598.2017.1289169","volume":"17","author":"M Sanlorenzo","year":"2017","unstructured":"Sanlorenzo M, Vujic I, Carnevale-Schianca F, et al. Role of interferon in melanoma: old hopes and new perspectives. Expert Opin Biol Ther 2017; 17: 475.","journal-title":"Expert Opin Biol Ther"},{"key":"440_CR34","doi-asserted-by":"publisher","first-page":"7335","DOI":"10.4049\/jimmunol.172.12.7335","volume":"172","author":"JC Lee","year":"2004","unstructured":"Lee JC, Lee KM, Kim DW, Heo DS. Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. J Immunol 2004; 172: 7335.","journal-title":"J Immunol"}],"container-title":["European Cytokine Network"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/ecn.2019.0440.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1684\/ecn.2019.0440\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/ecn.2019.0440.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.jle.com\/10.1684\/ecn.2019.0440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:27:33Z","timestamp":1790674053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.techscience.com\/ECN\/v30n4\/65387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["440"],"URL":"https:\/\/doi.org\/10.1684\/ecn.2019.0440","relation":{},"ISSN":["1952-4005"],"issn-type":[{"value":"1952-4005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"1 November 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 M\u00e4rz 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}