{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:20:43Z","timestamp":1783948843339,"version":"3.55.0"},"reference-count":12,"publisher":"JLE","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Dermatol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1684\/ejd.2018.3494","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T15:17:33Z","timestamp":1696864653000},"page":"55-58","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Analysis of the effect of different doses of oral tranexamic acid on melasma: a multicentre prospective study"],"prefix":"10.1684","volume":"29","author":[{"given":"Chen-Yu","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Ning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18929","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"3494_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/jdv.12049","volume":"27","author":"T Passeron","year":"2013","unstructured":"Passeron T. Melasma pathogenesis and influencing factors - an overview of the latest research. J Eur Acad Dermatol Venereol 2013; 27: 5\u20136.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3494_CR2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/01.dad.0000154419.18653.2e","volume":"27","author":"PE Grimes","year":"2005","unstructured":"Grimes PE, Yamada N, Bhawan J. Light microscopic, immunohistochemical, and ultrastructural alterations in patients with melasma. Am J Dermatopathol 2005; 27: 96\u2013101.","journal-title":"Am J Dermatopathol"},{"key":"3494_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3109\/14764172.2011.630088","volume":"13","author":"VN Sehgal","year":"2011","unstructured":"Sehgal VN, Verma P, Srivastava G, Aggarwal AK, Verma S. Melasma: treatment strategy. J Cosmet Laser Ther 2011; 13: 265\u201379.","journal-title":"J Cosmet Laser Ther"},{"key":"3494_CR4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.jaad.2016.03.001","volume":"75","author":"HC Lee","year":"2016","unstructured":"Lee HC, Thng TG, Goh CL. Oral tranexamic acid (TA) in the treatment of melasma: a retrospective analysis. J Am Acad Dermatol 2016; 75: 385\u201392.","journal-title":"J Am Acad Dermatol"},{"key":"3494_CR5","first-page":"3129","volume":"13","author":"T Nijor","year":"1979","unstructured":"Nijor T. Treatment of melasma with tranexamic acid. Clin Res 1979; 13: 3129\u201331.","journal-title":"Clin Res"},{"key":"3494_CR6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1248\/jhs.53.389","volume":"53","author":"K Maeda","year":"2007","unstructured":"Maeda K, Tomita Y. Mechanism of the inhibitory effect of tranexamic acid on melanogenesis in cultured human melanocytes in the presence of keratinocyte-conditioned medium. J Health Science 2007; 53: 389\u201396.","journal-title":"J Health Science"},{"key":"3494_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2165\/00128071-200910030-00002","volume":"10","author":"SG Ho","year":"2009","unstructured":"Ho SG, Chan HH. The Asian dermatologic patient. Am J Clin Dermatol 2009; 10: 153\u201368.","journal-title":"Am J Clin Dermatol"},{"key":"3494_CR8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1684\/ejd.2010.0912","volume":"20","author":"D Li","year":"2010","unstructured":"Li D, Shi Y, Li M, Liu J, Feng X. Tranexamic acid can treat ultraviolet radiation-induced pigmentation in guinea pigs. Eur J Dermatol 2010; 20: 289\u201392.","journal-title":"Eur J Dermatol"},{"key":"3494_CR9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jdermsci.2007.01.009","volume":"46","author":"EH Kim","year":"2007","unstructured":"Kim EH, Kim YC, Lee ES, Kang HY. The vascular characteristics of melasma. J Dermatol Sci 2007; 46: 111\u20136.","journal-title":"J Dermatol Sci"},{"key":"3494_CR10","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1111\/ced.12835","volume":"41","author":"SJ Kim","year":"2016","unstructured":"Kim SJ, Park JY, Shibata T, Fujiwara R, Kang HY. Efficacy and possible mechanisms of topical tranexamic acid in melasma. Clin Exp Dermatol 2016; 41: 480\u20135.","journal-title":"Clin Exp Dermatol"},{"key":"3494_CR11","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1111\/j.1468-3083.2012.04464.x","volume":"27","author":"J Na","year":"2013","unstructured":"Na J, Choi SY, Yang SH, Choi HR, Kang HY, Park KC. Effect of tranexamic acid on melasma: a clinical trial with histological evaluation. J Eur Acad Dermatol Venereol 2013; 27: 1035\u20139.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3494_CR12","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.det.2007.04.006","volume":"25","author":"F Prignano","year":"2007","unstructured":"Prignano F, Ortonne JP, Buggiani G, Lotti T. Therapeutical approaches in melasma. Dermatol Clin 2007; 25: 337\u201342.","journal-title":"Dermatol Clin"}],"container-title":["European Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/ejd.2018.3494.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1684\/ejd.2018.3494\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/ejd.2018.3494.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.jle.com\/10.1684\/ejd.2018.3494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T16:22:09Z","timestamp":1741191729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jle.com\/10.1684\/ejd.2018.3494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["3494"],"URL":"https:\/\/doi.org\/10.1684\/ejd.2018.3494","relation":{},"ISSN":["1952-4013"],"issn-type":[{"value":"1952-4013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"15 August 2018","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 Mai 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}