{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:23:01Z","timestamp":1783768981836,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report the case of a 32\u2010year\u2010old patient who presented with catatonic stupor during the course of acute aseptic encephalitis involving the right frontotemporal area. Flumazenil\u2010PET performed during the stupor indicated decreased benzodiazepine receptor binding in the right frontotemporal area where glucose metabolism was preserved as revealed by FDG\u2010PET. An injection of diazepam immediately ameliorated catatonic symptoms and reduced widespread high amplitude slow EEG activities with right frontotemporal predominance. Compared with a SPECT study performed a week earlier, there was no abnormal right\u2010sided anteriorly predominant cerebral hyperperfusion after injection of diazepam. While neither flumazenil\u2010 nor FDG\u2010PET could be repeated, and with the caveat that generalized convulsions occurred initially and epilepsia partialis continua was present for two weeks starting on the 23<jats:sup>rd<\/jats:sup> day after illness onset, these findings suggest that in our case the presentation with catatonic stupor may be related to impairment of the cortical GABAergic inhibitory system.<\/jats:p>","DOI":"10.1684\/epd.2009.0257","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:19Z","timestamp":1564752259000},"page":"126-131","source":"Crossref","is-referenced-by-count":22,"title":["Impairment of the cortical GABAergic inhibitory system in catatonic stupor: a case report with neuroimaging"],"prefix":"10.1002","volume":"11","author":[{"given":"Kazumi","family":"Iseki","sequence":"first","affiliation":[{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto"},{"name":"Human Motor Control Section Medical Neurology Branch National Institutes of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Hospital Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Hospital Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Hospital Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mezaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Hospital Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hanakawa","sequence":"additional","affiliation":[{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Hashikawa","sequence":"additional","affiliation":[{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenao","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyoto University Hospital Kyoto"},{"name":"Human Brain Research Center Kyoto University Graduate School of Medicine Kyoto"},{"name":"Department of Neurology Takeda General Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision. 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