{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:56:50Z","timestamp":1791205010831,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pre\u2010surgical and post\u2010surgical data were examined and compared from 215 consecutive patients undergoing surgery for intractable epilepsy. Patients were selected on the basis of a proven histopathological diagnosis of type I focal cortical dysplasia (FCD I), alone or associated with other lesions. The patients were divided into five sub\u2010groups:\n                    <jats:italic>i)<\/jats:italic>\n                    66 with isolated FCD I,\n                    <jats:italic>ii)<\/jats:italic>\n                    76 with FCD I and hippocampal sclerosis,\n                    <jats:italic>iii)<\/jats:italic>\n                    49 with FCD I and tumours,\n                    <jats:italic>iv)<\/jats:italic>\n                    16 with FCD I and other malformations of cortical development and\n                    <jats:italic>v)<\/jats:italic>\n                    eight with FCD I and anoxic\u2010ischaemic or inflammatory diseases. The duration of epilepsy was greatest in patients with FCD I associated with hippocampal sclerosis, and those with isolated FCD I showed the highest seizure frequency at the time of surgery. Hippocampal sclerosis and tumours were the most frequent pathological lesions associated with FCD I in temporal lobe epilepsy. Febrile seizures significantly correlated with the presence of hippocampal sclerosis and FCD I. Isolated FCD I was observed in 31% of the patients, characterized by frequent seizures, negative magnetic resonance imaging, and frequent frontal or multilobar involvement. In comparison to patients with FCD I associated with hippocampal sclerosis, MCD or tumours, the patients with isolated FCD I had a worse post\u2010surgical outcome (46% in class I). Our findings indicate that there is a high incidence of FCD I associated with other apparently distinct pathologies, particularly those affecting the temporal lobe, and highlight the need for a comprehensive clinicopathological approach for the classification of FCD I.\n                  <\/jats:p>","DOI":"10.1684\/epd.2010.0327","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:24:19Z","timestamp":1564737859000},"page":"181-191","source":"Crossref","is-referenced-by-count":122,"title":["Type I focal cortical dysplasia: surgical outcome is related to histopathology"],"prefix":"10.1002","volume":"12","author":[{"given":"Laura","family":"Tassi","sequence":"first","affiliation":[{"name":"C. Munari Epilepsy Surgery Centre Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Garbelli","sequence":"additional","affiliation":[{"name":"Division of Epilepsy Clinic and Experimental Neurophysiology C. Besta Neurological Institute IRCCS Foundation Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology C. Besta Neurological Institute IRCCS Foundation Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Bramerio","sequence":"additional","affiliation":[{"name":"Department of Pathology Niguarda Hospital C. Besta Neurological Institute IRCCS Foundation Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Lo","family":"Russo","sequence":"additional","affiliation":[{"name":"C. Munari Epilepsy Surgery Centre Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Deleo","sequence":"additional","affiliation":[{"name":"Division of Epilepsy Clinic and Experimental Neurophysiology C. Besta Neurological Institute IRCCS Foundation Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Milesi","sequence":"additional","affiliation":[{"name":"Division of Epilepsy Clinic and Experimental Neurophysiology C. Besta Neurological Institute IRCCS Foundation Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Spreafico","sequence":"additional","affiliation":[{"name":"Division of Epilepsy Clinic and Experimental Neurophysiology C. 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