{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:27:51Z","timestamp":1785511671115,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>There are some indications that seizure activity promotes the development of stroke\u2010like episodes, or vice versa, in patients with mitochondrial encephalopathy, lactic acidosis and stroke\u2010like episodes (MELAS) syndrome or other syndromic mitochondrial disorders. A 41\u2010year\u2010old Caucasian female with MELAS syndrome, presenting with short stature, microcytic anaemia, increased blood\u2010sedimentation rate, myopathy, hyper\u2010gammaglobulinaemia, an iron\u2010metabolism defect, migraine\u2010like headaches, and stroke\u2010like episodes, developed complex partial and generalised seizures at age 32 years. Valproic acid was ineffective but after switching to lamotrigine and lorazepam, she became seizure\u2010free for five years and stroke\u2010like episodes did not recur. Cerebral MRI initially showed enhanced gyral thickening and a non\u2010enhanced T2\u2010hyperintensity over the left parieto\u2010temporo\u2010occipital white matter and cortex and enhanced caudate heads. After two years without seizures, the non\u2010enhanced hyperintense parieto\u2010temporo\u2010occipital lesion had disappeared, being attributed to consequent seizure control. The caudate heads, however, remained hyperintense throughout the observational period. This case indicates that adequate seizure control in a patient with MELAS syndrome may prevent the recurrence of stroke\u2010like episodes and may result in the disappearance of strokelike lesions on MRI.<\/jats:p>","DOI":"10.1684\/epd.2010.0338","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:49:20Z","timestamp":1697834960000},"page":"330-334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Regression of stroke\u2010like lesions in MELAS\u2010syndrome after seizure control"],"prefix":"10.1002","volume":"12","author":[{"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[{"name":"Krankenanstalt Rudolfstiftung Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Barton","sequence":"additional","affiliation":[{"name":"Institute of Radiology Urania Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000261929.92478.3e"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480540903207076"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00836.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000091888.26232.FE"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.6.816"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.03.012"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.01.003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.01.006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-006-9039-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340000335"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.309"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010537527291"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.523118"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/epd.2010.0338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1684\/epd.2010.0338\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/epd.2010.0338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2010.0338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:31:05Z","timestamp":1710779465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2010.0338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1684\/epd.2010.0338"],"URL":"https:\/\/doi.org\/10.1684\/epd.2010.0338","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"3 Februar 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 Januar 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}