{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:42:08Z","timestamp":1769604128937,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Benign convulsions associated with gastroenteritis are now recognized as a clinical entity, characterized by an acute cluster of afebrile seizures during an episode of mild diarrhoea with excellent prognosis. We observed 30 children who each experienced at least two seizures associated with mild gastroenteritis. The inclusion criteria were: afebrile seizures during gastroenteritis, dehydration at \u2264 5%, normal neurological findings, normal psychomotor development and no underlying pathology according to laboratory and neuroimaging studies. Mean age was 21 months (range: 6\u201038). Familial history for epilepsy was positive in 3\/30 (10%) and for febrile convulsions in 11\/30 (36.6%). Seizure onset was mainly on the third day of gastroenteritis. Seizures were described as generalised by parents in 16\/30 patients (53.3%). We directly observed seizures in 14\/30 patients (47.7%), and the semiology was partial with secondary generalisation. Focal onset was confirmed in two patients by EEG and in two patients by video\u2010EEG recording. Twenty of 30 patients (66.6%) received antiepileptic drugs during the acute phase. Ten patients (33.3%) received no treatment. During follow\u2010up (mean duration: 53 months), one patient had an isolated afebrile seizure and two others a febrile seizure. At the end of follow\u2010up, antiepileptic treatment was withdrawn for all but two patients. None developed epilepsy. Although the pathogenesis of this clinical entity is unknown, we hypothesize that mild gastroenteritis may provoke a transient brain dysfunction which in turn provokes seizures in children with genetically determined susceptibility. <jats:italic>[Published with video sequences]<\/jats:italic><\/jats:p>","DOI":"10.1684\/epd.2010.0340","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:49:22Z","timestamp":1697834962000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Convulsions associated with gastroenteritis in the spectrum of benign focal epilepsies in infancy: 30 cases including four cases with ictal EEG recording"],"prefix":"10.1002","volume":"12","author":[{"given":"Raffaella","family":"Cusmai","sequence":"first","affiliation":[{"name":"Neurology Unit Bambino Ges\u00f9 Children's Hospital IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosanka","family":"Jocic\u2010Jakubi","sequence":"additional","affiliation":[{"name":"Clinical Center Nis Pediatric Clinic School of Medicine Nis Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cantonetti","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Rehabilitation Bambino Ges\u00f9 Children's Hospital IRCCS Santa Marinella\u2010Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natia","family":"Japaridze","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epilepsy M. Iashvili Children's Central Hospital Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Vigevano","sequence":"additional","affiliation":[{"name":"Neurology Unit Bambino Ges\u00f9 Children's Hospital IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(00)00111-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101601202"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.110221"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807307083"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01464.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01445.x"},{"key":"e_1_2_6_8_1","first-page":"493","article-title":"Low\u2010dose therapy with carbamazepine for convulsions associated with mild gastroenteritis","volume":"37","author":"Ichiyama T","year":"2005","journal-title":"No To Hattatsu"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb02020.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807304703"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2007.03.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0387-7604(95)00074-L"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.06.002"},{"key":"e_1_2_6_14_1","first-page":"131","article-title":"Convulsions and mild diarrhea","volume":"23","author":"Morooka K","year":"1982","journal-title":"Shonika Rinsho"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-4-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0387-7604(93)90088-P"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.08.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(03)00121-9"},{"key":"e_1_2_6_19_1","first-page":"368","article-title":"Clinical study of convulsions with mild gastroenteritis","volume":"106","author":"Omata T","year":"2002","journal-title":"Nihon Shonika Gakkai Zasshi (Tokio)"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.01.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00097-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.12.012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199007000-00006"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101601208"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/epd.2010.0340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1684\/epd.2010.0340\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1684\/epd.2010.0340.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2010.0340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:30:44Z","timestamp":1710779444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2010.0340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1684\/epd.2010.0340"],"URL":"https:\/\/doi.org\/10.1684\/epd.2010.0340","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"23 Februar 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 Januar 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}