{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:27:57Z","timestamp":1761017277620},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Childhood absence epilepsy (CAE) typically starts between four and seven years of age. Onset before three years is rare and has not been previously reported from North America. We retrospectively reviewed the electroencephalography laboratory database and paediatric neurology clinic records (from January 2000 to June 2009) at our institution in order to identify patients with absence seizures beginning before age three. Information was collected for age, gender, neurodevelopment, antiepileptic drugs (AEDs) used, seizure control, follow\u2010up, and side effects. Of 12 patients identified, mean age at onset was 20.5 months (range:11 months to two years; follow\u2010up: six months to 11 years). Seven of 12 patients had normal neurodevelopment and five had speech delay. Four patients were seizure\u2010free without AEDs, three were seizure\u2010free with a single AED, and five still had seizures with multiple AEDs. Three patients had recurrences after medication withdrawal. Other previously published series have identified better seizure control than that reported here, however, 16% of the 130 patients so far documented are reported to have poorly controlled epilepsy, indicating that early\u2010onset CAE is not a homogeneous condition. The debate as to whether early\u2010onset CAE is a distinct epilepsy syndrome therefore continues. We believe that early\u2010onset CAE may be a distinct epilepsy syndrome, with some features that overlap with those of typical CAE, as well as unique distinguishing features. Large prospective multicentric studies would be necessary to definitely resolve this matter.<\/jats:p>","DOI":"10.1684\/epd.2011.0465","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:24:19Z","timestamp":1564752259000},"page":"411-416","source":"Crossref","is-referenced-by-count":8,"title":["Early\u2010onset childhood absence epilepsy: is it a distinct entity?"],"prefix":"10.1002","volume":"13","author":[{"given":"Pue","family":"Farooque","sequence":"first","affiliation":[{"name":"Department of Neurology Hahnemann University Hospital 245 North 15th Street Philadelphia PA 19102 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatinder","family":"Goraya","sequence":"additional","affiliation":[{"name":"Section of Child Neurology St. Christopher's Hospital for Children 3601 A Street Philadelphia PA 19134 USA"},{"name":"Department of Pediatrics Drexel University of College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Valencia","sequence":"additional","affiliation":[{"name":"Section of Child Neurology St. Christopher's Hospital for Children 3601 A Street Philadelphia PA 19134 USA"},{"name":"Department of Pediatrics Drexel University of College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Section of Child Neurology St. Christopher's Hospital for Children 3601 A Street Philadelphia PA 19134 USA"},{"name":"Department of Pediatrics Drexel University of College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Huntley","family":"Hardison","sequence":"additional","affiliation":[{"name":"Section of Child Neurology St. Christopher's Hospital for Children 3601 A Street Philadelphia PA 19134 USA"},{"name":"Department of Pediatrics Drexel University of College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agustin","family":"Legido","sequence":"additional","affiliation":[{"name":"Section of Child Neurology St. Christopher's Hospital for Children 3601 A Street Philadelphia PA 19134 USA"},{"name":"Department of Pediatrics Drexel University of College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya S","family":"Khurana","sequence":"additional","affiliation":[{"name":"Section of Child Neurology St. Christopher's Hospital for Children 3601 A Street Philadelphia PA 19134 USA"},{"name":"Department of Pediatrics Drexel University of College of Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"284","volume-title":"Absences and related epileptic syndromes","author":"Aicardi J","year":"1995"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02926.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05342.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.54902.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","unstructured":"CovanisA. EEG and clinical correlates of early\u2010onset typical absences (age less than three years) [abstract]. In Third European Congress Proceedings Third European Congress of Epileptology Warsaw Poland May 24\u201028 1998.Epilepsia39 (Suppl 2):92. doi:10.1111\/j.1528\u20101157.1998.tb01895.x.","DOI":"10.1111\/j.1528-1157.1998.tb01895.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101157.1996.tb01721.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.10.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.03.017"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902014"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.13802.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.41503.x"},{"key":"e_1_2_6_14_1","first-page":"653","article-title":"Valproic acid versus lamotrigine as a monotherapy for absence epilepsy in children","volume":"11","author":"Huang TS","year":"2009","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.01.014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.2.157"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.02.015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02213.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.12.015"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2011.0465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:21:30Z","timestamp":1710778890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2011.0465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1684\/epd.2011.0465"],"URL":"https:\/\/doi.org\/10.1684\/epd.2011.0465","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}