{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:22:09Z","timestamp":1787023329329,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prolonged status epilepticus may directly cause selective neuronal necrosis due to excitotoxic mechanisms, as observed in experimental models and described in case reports. A 36\u2010year\u2010old woman presented with right hemiplegia and aphasia following a generalised tonic\u2010clonic status epilepticus of two hours duration. Accompanying serial MRI with advanced imaging techniques, EEG and histopathology of the cortical tissue of the patient were all compatible with excitotoxic neuronal necrosis. In this histopathologically\u2010proven rare case of status epilepticus\u2010induced excitotoxic neuronal injury, the observation of delayed cortical laminar necrosis on MRI, together with paroxysmal lateralised epileptiform discharges on the EEG, suggests that these changes may be an early sign of impending and ongoing excitotoxic neuronal injury and delayed cell death caused by glutamate release due to excessive neuronal firing in status epilepticus.<\/jats:p>","DOI":"10.1684\/epd.2011.0472","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:24:19Z","timestamp":1564737859000},"page":"446-451","source":"Crossref","is-referenced-by-count":9,"title":["Serial EEG and MRI changes in status epilepticus\u2010induced excitotoxic neuronal necrosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Fehim","family":"Arman","sequence":"first","affiliation":[{"name":"Department of Neurology Acibadem University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilaver","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Neurology Acibadem University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp","family":"Dincer","sequence":"additional","affiliation":[{"name":"Department of Radiology Acibadem University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydin","family":"Sav","sequence":"additional","affiliation":[{"name":"Department of Pathology Acibadem University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Necmettin","family":"Pamir","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Acibadem University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05492.x"},{"key":"e_1_2_5_3_1","first-page":"129","volume-title":"Status epilepticus: mechanisms of brain damage and treatment","author":"Corsellis JAN","year":"1983"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb02278.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.058701"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(89)90025-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb00979.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00283.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.12.2160"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.9_suppl_5.S3"},{"key":"e_1_2_5_11_1","first-page":"1837","article-title":"Selective neuronal necrosis associated with status epilepticus: MR findings","volume":"21","author":"Men S","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200616"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.12.005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb05905.x"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2011.0472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T12:21:59Z","timestamp":1710764519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2011.0472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1684\/epd.2011.0472"],"URL":"https:\/\/doi.org\/10.1684\/epd.2011.0472","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}